Natural Xylooligosaccharides Exert Antitumor Activity via Modulation of Cellular Antioxidant State and TLR4

Article Chemistry, Applied

β(2→6)-Type fructans attenuate proinflammatory responses in a structure dependent fashion via Toll-like receptors

C. Fernandez-Lainez et al.

Summary: The study reveals that GTFs have immunomodulatory effects through their interaction with Toll-like receptors (TLRs), and can attenuate the production of pro-inflammatory cytokines in dendritic cells (DCs).

CARBOHYDRATE POLYMERS (2022)

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Article Plant Sciences

Addition of Medicinal Plants Increases Antioxidant Activity, Color, and Anthocyanin Stability of Black Chokeberry (Aronia melanocarpa) Functional Beverages

Desislava Teneva et al.

Summary: This study investigates the effects of adding medicinal plants on the chemical composition, antioxidant activity, and color intensity of ready-to-drink aronia nectar. The study found that pasteurization caused a decrease in anthocyanin content, but the addition of medicinal plants slowed down the degradation of anthocyanins. Additionally, the plants enriched the nectar with phenolic compounds, increased antioxidant activity, and enhanced color intensity through co-pigmentation.

PLANTS-BASEL (2022)

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Article Chemistry, Medicinal

Toll-like receptor 4 (TLR4) inhibitors: Current research and prospective

Yongsheng Zhang et al.

Summary: This review discusses TLR4 inhibitors that can bind directly to TLR4 or the TLR4/MD2 complex, as well as compounds that can downregulate the expression of TLR4. The involvement of specific residues in the binding of antagonistic ligands to the TLR4/MD2 complex provides useful information for structure-based TLR4 inhibitor design.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2022)

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Review Nutrition & Dietetics

Xylo-Oligosaccharides, Preparation and Application to Human and Animal Health: A Review

Yuxia Chen et al.

Summary: Xylo-oligosaccharides (XOS) are functional oligosaccharides with great prebiotic potential, derived from the degradation of xylan. They exhibit various functional biological activities, can be applied to food and feed products, and have been shown to improve health.

FRONTIERS IN NUTRITION (2021)

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Review Chemistry, Applied

Xylooligosaccharides from lignocellulosic biomass: A comprehensive review

Luciana Santibanez et al.

Summary: This article reviews the relevant topics to consider when researching XOS productive processes, including raw material selection, production, purification, and evaluation strategies. The lack of consensus on criteria and parameters used in the evaluation of XOS production processes makes comparative analysis between different studies difficult.

CARBOHYDRATE POLYMERS (2021)

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Article Food Science & Technology

Prebiotic properties, antioxidant activity, and acute oral toxicity of xylooligosaccharides derived enzymatically from corncob

Pinpanit Boonchuay et al.

Summary: The study showed that corncob xylooligosaccharides are a good prebiotic that can promote the growth of probiotic lactic acid bacteria and have excellent radical scavenging activities and antioxidant power. Acute oral toxicity tests revealed that corncob-XOS at a dose of 5000 mg/kg bw showed no toxic effects, indicating it could be further applied as functional foods.

FOOD BIOSCIENCE (2021)

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Article Biochemistry & Molecular Biology

Multi-efficient thermostable endoxylanase from Bacillus velezensis AG20 and its production of xylooligosaccharides as efficient prebiotics with anticancer activity

Arabinda Ghosh et al.

Summary: The study reveals the novel potential of xylanase production by Bacillus velezensis, showing stable and multisubstrate hydrolyzing properties of the purified enzyme at high temperatures. Enzymatic hydrolysis of waste material produces xylooligosaccharides beneficial for probiotic bacteria and inhibiting cell proliferation significantly.

PROCESS BIOCHEMISTRY (2021)

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Article Pharmacology & Pharmacy

Effects of Xylooligosaccharides on Lipid Metabolism, Inflammation, and Gut Microbiota in C57BL/6J Mice Fed a High-Fat Diet

Fang Li et al.

Summary: Xylooligosaccharide (XOS) shows potential in preventing hyperlipidemia by inhibiting weight gain, improving blood lipid levels, and alleviating liver damage, while also regulating the intestinal barrier and optimizing the intestinal microbiota composition.

FRONTIERS IN PHARMACOLOGY (2021)

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Article Environmental Sciences

Xylo-Oligosaccharides in Prevention of Hepatic Steatosis and Adipose Tissue Inflammation: Associating Taxonomic and Metabolomic Patterns in Fecal Microbiomes with Biclustering

Jukka Hintikka et al.

Summary: The study demonstrated that prebiotic xylo-oligosaccharides (XOS) had beneficial effects on hepatic steatosis under high fat diet conditions by reducing adipose tissue inflammation and potentially improving insulin signaling. These effects were associated with fecal metabolites and gut microbiota.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2021)

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Article Agricultural Engineering

Production of xylo-oligosaccharides from wheat straw using microwave assisted deep eutectic solvent pretreatment

Asli Isci et al.

Summary: This study investigated the effect of microwave assisted deep eutectic solvent pretreatment on the solubilization of xylan and release of xylo-oligosaccharides from wheat straw. It was found that the increase in microwave energy led to linear decrease in xylan yield in the solid fraction, while the xylose monomer and oligosaccharide yields in the liquid fraction initially increased and then declined. Addition of water in deep eutectic solvent resulted in approximately 68% reduction in furfural yield.

INDUSTRIAL CROPS AND PRODUCTS (2021)

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Review Biotechnology & Applied Microbiology

Xylanolytic Bacillus species for xylooligosaccharides production: a critical review

Rozina Rashid et al.

Summary: Different Bacillus species have shown great potential in industrial production due to their ability to produce extracellular enzymes and ferment various substrates. They are especially promising hosts for producing prebiotics like XOs. Large-scale production of XOs involves processes such as purification and application, with potential health benefits and other biological impacts discussed.

BIORESOURCES AND BIOPROCESSING (2021)

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Review Oncology

Toll-like Receptors from the Perspective of Cancer Treatment

Nasir Javaid et al.

CANCERS (2020)

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Article Physiology

Xylooligosaccharide Modulates Gut Microbiota and Alleviates Colonic Inflammation Caused by High Fat Diet Induced Obesity

Yanquan Fei et al.

FRONTIERS IN PHYSIOLOGY (2020)

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Article Polymer Science

Metabolic Profiling of Xylooligosaccharides by Lactobacilli

Ilia Iliev et al.

POLYMERS (2020)

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Review Biochemistry & Molecular Biology

Role of Glutathione in Cancer: From Mechanisms to Therapies

Luke Kennedy et al.

BIOMOLECULES (2020)

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Article Biotechnology & Applied Microbiology

Structural characterization of hemicellulose released from corn cob in continuous flow type hydrothermal reactor

Tsutomu Arai et al.

JOURNAL OF BIOSCIENCE AND BIOENGINEERING (2019)

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Review Plant Sciences

Xylan in the Middle: Understanding Xylan Biosynthesis and Its Metabolic Dependencies Toward Improving Wood Fiber for Industrial Processing

Martin P. Wierzbicki et al.

FRONTIERS IN PLANT SCIENCE (2019)

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Review Biotechnology & Applied Microbiology

From lignocellulosic residues to market: Production and commercial potential of xylooligosaccharides

Claudia Amorim et al.

BIOTECHNOLOGY ADVANCES (2019)

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Article Biochemistry & Molecular Biology

IEDB-AR: immune epitope database-analysis resource in 2019

Sandeep Kumar Dhanda et al.

NUCLEIC ACIDS RESEARCH (2019)

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Article Agricultural Engineering

Spray-dried xylooligosaccharides carried by gum Arabic

Liangqing Zhang et al.

INDUSTRIAL CROPS AND PRODUCTS (2019)

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Article Food Science & Technology

Epigallocatechin-3-Gallate Attenuates Microglial Inflammation and Neurotoxicity by Suppressing the Activation of Canonical and Noncanonical Inflammasome via TLR4/NF-κB Pathway

Xin Zhong et al.

MOLECULAR NUTRITION & FOOD RESEARCH (2019)

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Review Nutrition & Dietetics

Targeting Glutathione Metabolism: Partner in Crime in Anticancer Therapy

Enrico Desideri et al.

NUTRIENTS (2019)

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Article Biology

Analysis of the Mitochondrial Membrane Potential Using the Cationic JC-1 Dye as a Sensitive Fluorescent Probe

Farzane Sivandzade et al.

BIO-PROTOCOL (2019)

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Article Biochemistry & Molecular Biology

Glutathione reductase mediates drug resistance in glioblastoma cells by regulating redox homeostasis

Zhongling Zhu et al.

JOURNAL OF NEUROCHEMISTRY (2018)

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Article Food Science & Technology

Fourier transform infrared and Raman spectroscopic study of the effect of the thermal treatment and extraction methods on the characteristics of ayocote bean starches

Aurea Bernardino-Nicanor et al.

JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE (2017)

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Review Biochemistry & Molecular Biology

The Role of Carbohydrates in the Lipopolysaccharide (LPS)/Toll-Like Receptor 4 (TLR4) Signalling

Florent Cochet et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

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Article Biochemistry & Molecular Biology

A systematic analysis of atomic protein-ligand interactions in the PDB

Renato Ferreira de Freitas et al.

MEDCHEMCOMM (2017)

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Review Gastroenterology & Hepatology

Prebiotics: A Novel Approach to Treat Hepatocellular Carcinoma

Naz Fatima et al.

CANADIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2017)

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Article Agricultural Engineering

Co-production of functional xylooligosaccharides and fermentable sugars from corncob with effective acetic acid prehydrolysis

Hongyu Zhang et al.

BIORESOURCE TECHNOLOGY (2017)

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Article Chemistry, Applied

Isolation and characterization of acetylated glucuronoarabinoxylan from sugarcane bagasse and straw

Danila Morais de Carvalho et al.

CARBOHYDRATE POLYMERS (2017)

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Article Physiology

Xylooligosaccharide supplementation alters gut bacteria in both healthy and prediabetic adults: a pilot study

Jieping Yang et al.

FRONTIERS IN PHYSIOLOGY (2015)

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Article Chemistry, Medicinal

Pharmacophore modeling for COX-1 and-2 inhibitors with LigandScout in comparison to Discovery Studio

Veronika Temml et al.

FUTURE MEDICINAL CHEMISTRY (2014)

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Article Agricultural Engineering

Structural features and antioxidant activity of xylooligosaccharides enzymatically produced from sugarcane bagasse

Jing Bian et al.

BIORESOURCE TECHNOLOGY (2013)

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Article Nutrition & Dietetics

Dietary Xylooligosaccharide Downregulates IFN-γ and the Low-Grade Inflammatory Cytokine IL-1β Systemically in Mice

Camilla H. F. Hansen et al.

JOURNAL OF NUTRITION (2013)

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Article Biochemistry & Molecular Biology

Induction of Apoptosis in MCF-7 Cells by β-1,3-Xylooligosaccharides Prepared from Caulerpa lentillifera

Reiko Maeda et al.

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY (2012)

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Article Food Science & Technology

Immunomodulatory Effects of Xylooligosaccharides

Hua Han Chen et al.

FOOD SCIENCE AND TECHNOLOGY RESEARCH (2012)

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Article Biochemistry & Molecular Biology

UCSF Chimera, MODELLER, and IMP: An integrated modeling system

Zheng Yang et al.

JOURNAL OF STRUCTURAL BIOLOGY (2012)

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Article Oncology

LPS-Induced TLR4 Signaling in Human Colorectal Cancer Cells Increases β1 Integrin-Mediated Cell Adhesion and Liver Metastasis

Rich Y. C. Hsu et al.

CANCER RESEARCH (2011)

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Article Biochemistry & Molecular Biology

Synthesis of Xylooligosaccharides of Daidzein and Their Anti-Oxidant and Anti-Allergic Activities

Kei Shimoda et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2011)

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Article Chemistry, Multidisciplinary

Open Babel: An open chemical toolbox

Noel M. O'Boyle et al.

JOURNAL OF CHEMINFORMATICS (2011)

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Article Biotechnology & Applied Microbiology

Structural and physico-chemical characterization of hemicelluloses from ultrasound-assisted extractions of partially delignified fast-growing poplar wood through organic solvent and alkaline solutions

Tong-Qi Yuan et al.

BIOTECHNOLOGY ADVANCES (2010)

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Letter Hematology

Toll-like Receptors (TLRs) are expressed by myeloid leukaemia cell lines, but fail to trigger differentiation in response to the respective TLR ligands

Masashi Okamoto et al.

BRITISH JOURNAL OF HAEMATOLOGY (2009)

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Review Biochemistry & Molecular Biology

Firefly Bioluminescence: A Mechanistic Approach of Luciferase Catalyzed Reactions

Simone M. Marques et al.

IUBMB LIFE (2009)

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Article Nutrition & Dietetics

Effects of Xylooligosaccharides in Type 2 Diabetes Mellitus

Wayne Huey-Herng Sheu et al.

JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY (2008)

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Article Biochemical Research Methods

Neutral red uptake assay for the estimation of cell viability/cytotoxicity

Guillermo Repetto et al.

NATURE PROTOCOLS (2008)

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Article Food Science & Technology

Inhibitory effects of acidic xylooligosaccharide on stress-induced gastric inflammation in mice

Kyoji Yoshino et al.

JOURNAL OF THE FOOD HYGIENIC SOCIETY OF JAPAN (2006)

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Article Toxicology

In vitro cytotoxicity assays: Comparison of LDH, neutral red, MTT and protein assay in hepatoma cell lines following exposure to cadmium chloride

G Fotakis et al.

TOXICOLOGY LETTERS (2006)

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Review Biochemistry & Molecular Biology

Advances in the manufacture, purification and applications of xylo-oligosaccharides as food additives and nutraceuticals

Andres Moure et al.

PROCESS BIOCHEMISTRY (2006)

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Article Biochemistry & Molecular Biology

Response of human pulmonary epithelial cells to lipopolysaccharide involves Toll-like receptor 4 (TLR4)-dependent signaling pathways - Evidence for an intracellular compartmentalization of TLR4

L Guillot et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

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Article Toxicology

Hot-compressed-water decomposed products from bamboo manifest a selective cytotoxicity against acute lymphoblastic leukemia cells

H Ando et al.

TOXICOLOGY IN VITRO (2004)

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Article Nutrition & Dietetics

Xylooligosaccharides and fructooligosaccharides affect the intestinal microbiota and precancerous colonic lesion development in rats

CK Hsu et al.

JOURNAL OF NUTRITION (2004)

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Article Chemistry, Applied

Fourier transform Raman and infrared spectroscopy of pectins

A Synytsya et al.

CARBOHYDRATE POLYMERS (2003)

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Article Agriculture, Multidisciplinary

Novel fluorometric assay for hydroxyl radical prevention capacity using fluorescein as the probe

B Ou et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2002)

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Article Agriculture, Multidisciplinary

Development and validation of an improved oxygen radical absorbance capacity assay using fluorescein as the fluorescent probe

BX Ou et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2001)

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Article Chemistry, Applied

FT-IR study of plant cell wall model compounds:: pectic polysaccharides and hemicelluloses

M Kacuráková et al.

CARBOHYDRATE POLYMERS (2000)

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Natural Xylooligosaccharides Exert Antitumor Activity via Modulation of Cellular Antioxidant State and TLR4

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