☆ 4.7 Review

Update on Extracellular Vesicle-Based Vaccines and Therapeutics to Combat COVID-19

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Multidisciplinary Sciences

Circulating ACE2-expressing extracellular vesicles block broad strains of SARS-CoV-2

Lamiaa El-Shennawy et al.

Summary: El-Shennawy et al. found that circulating extracellular vesicles (evACE2) are associated with COVID-19 severity and have a higher efficacy in inhibiting the infection of SARS-CoV-2 variants compared to soluble ACE2. This study is important for the development of therapeutic approaches against current and future coronavirus infections.

NATURE COMMUNICATIONS (2022)

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Article Immunology

Exosomes Recovered From the Plasma of COVID-19 Patients Expose SARS-CoV-2 Spike-Derived Fragments and Contribute to the Adaptive Immune Response

Elisa Pesce et al.

Summary: This study compared exosomes recovered from the plasma of MILD or SEVERE COVID-19 patients and found that exosomes from MILD patients efficiently regulated immune responses, while those from SEVERE patients were associated with increased and chronic inflammation.

FRONTIERS IN IMMUNOLOGY (2022)

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Article Cell Biology

Engineered small extracellular vesicles displaying ACE2 variants on the surface protect against SARS-CoV-2 infection

Hark Kyun Kim et al.

Summary: This study presents a method of using small extracellular vesicles (sEVs) to deliver soluble ACE2 (sACE2) and inhibit the entry of SARS-CoV-2. The researchers found that sACE2 variants loaded in sEVs showed higher antiviral efficacy compared to wild-type sACE2, and could inhibit the entry of different variants of SARS-CoV-2.

JOURNAL OF EXTRACELLULAR VESICLES (2022)

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Review Biotechnology & Applied Microbiology

Therapeutically harnessing extracellular vesicles

Lesley Cheng et al.

Summary: The field of extracellular vesicle (EV) research has rapidly developed and is now recognized for its potential in the treatment and diagnosis of diseases. This article provides an overview of the characteristics and physiological functions of EVs, their association with diseases, and the strategies for their therapeutic exploitation.

NATURE REVIEWS DRUG DISCOVERY (2022)

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Review Cell & Tissue Engineering

Mesenchymal Stem Cell-Derived Extracellular Vesicles in the Management of COVID19-Associated Lung Injury: A Review on Publications, Clinical Trials and Patent Landscape

Anand Krishnan et al.

Summary: Researchers are exploring the use of MSC-derived EVs as a therapeutic approach for COVID-19, which are easier to store and deliver compared to MSCs, and are less immunogenic.

TISSUE ENGINEERING AND REGENERATIVE MEDICINE (2022)

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Article Cell & Tissue Engineering

Nebulized exosomes derived from allogenic adipose tissue mesenchymal stromal cells in patients with severe COVID-19: a pilot study

Ying-Gang Zhu et al.

Summary: This study explores the safety and efficacy of aerosol inhalation of exosomes derived from human adipose-derived MSCs (haMSC-Exos) in COVID-19 patients. The results show that a consecutive 5-day inhalation dose of haMSC-Exos is feasible and well tolerated, with no evidence of adverse events and CT imaging improvement within 7 days.

STEM CELL RESEARCH & THERAPY (2022)

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Article Medicine, Research & Experimental

Engineered extracellular vesicles directed to the spike protein inhibit SARS-CoV-2

Tristan A. Scott et al.

Summary: SARS-CoV-2 viral infection leads to COVID-19 disease, emphasizing the importance of vaccines and therapeutics. The study presents a molecular therapy using extracellular vesicles and anti-CoV-2 nanobody to neutralize SARS-CoV-2, targeting the early stages of infection.

MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT (2022)

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Article Cell Biology

A bacterial extracellular vesicle-based intranasal vaccine against SARS-CoV-2 protects against disease and elicits neutralizing antibodies to wild-type and Delta variants

Linglei Jiang et al.

Summary: This study presents a novel SARS-CoV-2 vaccine candidate based on extracellular vesicles (EVs) that are decorated with the Spike receptor-binding domain (RBD). The vaccine candidate induced high titres of antibodies and demonstrated neutralizing antibody activity against wild-type and Delta variants. Animal experiments showed that hamsters immunized with the RBD-OMV vaccine had better protection against virus infection and experienced less severe pathology.

JOURNAL OF EXTRACELLULAR VESICLES (2022)

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Letter Cell Biology

ACE2-enriched extracellular vesicles enhance infectivity of live SARS-CoV-2 virus

Sze Keong Tey et al.

JOURNAL OF EXTRACELLULAR VESICLES (2022)

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Article Medicine, Research & Experimental

A novel platform for attenuating immune hyperactivity using EXO-CD24 in COVID-19 and beyond

Shiran Shapira et al.

Summary: The new anti-inflammatory drug EXO-CD24 has shown potential in suppressing the hyper-inflammatory response in COVID-19 patients and may serve as a therapeutic platform for other diseases characterized by cytokine storm.

EMBO MOLECULAR MEDICINE (2022)

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Article Engineering, Biomedical

Exosomes decorated with a recombinant SARS-CoV-2 receptor-binding domain as an inhalable COVID-19 vaccine

Zhenzhen Wang et al.

Summary: Researchers have developed an inhalable and room-temperature-stable virus-like particle COVID-19 vaccine that induces systemic and mucosal immune responses in small animals. The vaccine, consisting of a recombinant SARS-CoV-2 receptor-binding domain conjugated to lung-derived exosomes, enhanced the retention of the receptor-binding domain in the respiratory airway and lungs, and cleared SARS-CoV-2 pseudovirus in mice. In hamsters, the vaccine attenuated severe pneumonia and reduced inflammatory infiltrates after a challenge with live SARS-CoV-2.

NATURE BIOMEDICAL ENGINEERING (2022)

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Article Materials Science, Multidisciplinary

Inhalable dry powder mRNA vaccines based on extracellular vesicles

Kristen D. Popowski et al.

Summary: Respiratory diseases are a major global burden, and the development of effective therapeutics is limited. Researchers have developed a stable inhalable form of extracellular vesicles that can effectively deliver drugs to the lungs and have shown promising results in vaccine applications.

MATTER (2022)

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Article Cell & Tissue Engineering

Nebulization Therapy with Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes for COVID-19 Pneumonia

Meiping Chu et al.

Summary: This study demonstrates that nebulization therapy with exosomes of mesenchymal stem cells (MSCs) may be an effective method for treating COVID-19 pneumonia. Nebulization of MSC-derived exosomes does not induce allergic reactions and can promote the absorption of pulmonary lesions, reducing hospitalization duration for mild cases.

STEM CELL REVIEWS AND REPORTS (2022)

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Review Oncology

Novel insights into the function ofCD24: A driving force in cancer

Peter Altevogt et al.

Summary: CD24 is a highly glycosylated protein expressed primarily by immune cells and often overexpressed in human tumors. It plays a role in regulating cell migration, invasion and proliferation in cancer, associated with poor prognosis and used as a cancer stemness marker. The review summarizes recent progress on the role of CD24-Siglec-10 binding axis in tumor immunity and the potential of CD24-based immunotherapy in cancer.

INTERNATIONAL JOURNAL OF CANCER (2021)

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Editorial Material Gastroenterology & Hepatology

Angiotensin-converting Enzyme 2-containing Small Extracellular Vesicles and Exomeres Bind the Severe Acute Respiratory Syndrome Coronavirus 2 Spike Protein

Qin Zhang et al.

GASTROENTEROLOGY (2021)

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Article Respiratory System

Treatment of a COVID-19 long hauler with an amniotic fluid-derived extracellular vesicle biologic

Maria Ines Mitrani et al.

Summary: Long haulers suffering from post-COVID-19 symptoms face a lack of medical guidance and treatment options, although research suggests that EVs derived from amniotic fluid may have therapeutic potential.

RESPIRATORY MEDICINE CASE REPORTS (2021)

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Article Chemistry, Multidisciplinary

Engineering Extracellular Vesicles Enriched with Palmitoylated ACE2 as COVID-19 Therapy

Feng Xie et al.

Summary: ACE2 plays a key role in the interaction with SARS-CoV-2, and its levels in extracellular vesicles are regulated by protein palmitoylation. Modifying ACE2 with palmitoylation affects its membrane-targeting and secretion in EVs, showing potential for neutralizing SARS-CoV-2.

ADVANCED MATERIALS (2021)

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Article Virology

Diverse Populations of Extracellular Vesicles with Opposite Functions during Herpes Simplex Virus 1 Infection

Christos Dogrammatzis et al.

Summary: Extracellular vesicles play a crucial role in intercellular communication and can alter recipient cell functions despite their limited cargo capacity. This study identified distinct populations of EVs released during HSV-1 infection, with CD63(+) EVs being selectively induced and having a negative impact on the infection. The results suggest complex interactions between the virus and host through EVs, potentially affecting HSV-1 dissemination and persistence.

JOURNAL OF VIROLOGY (2021)

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Article Biochemistry & Molecular Biology

Exosome-mediated mRNA delivery in vivo is safe and can be used to induce SARS-CoV-2 immunity

Shang Jui Tsai et al.

Summary: Exosomes can be used as a promising delivery vehicle for functional mRNA, demonstrating efficient delivery to human cells and potential for clinical applications.

JOURNAL OF BIOLOGICAL CHEMISTRY (2021)

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Article Biochemistry & Molecular Biology

Circulating Exosomes Are Strongly Involved in SARS-CoV-2 Infection

Elettra Barberis et al.

Summary: Limited knowledge of the host response to SARS-CoV-2 hinders understanding of COVID-19 pathogenesis and therapeutic strategies. This study revealed that SARS-CoV-2 infection modulates exosome content and their involvement in disease progression, highlighting the potential of plasma exosomes as biomarkers for disease severity. Proteomic analysis of patient-derived exosomes identified molecules implicated in immune response, inflammation, coagulation, and complement pathways associated with COVID-19 tissue damage and organ dysfunction. Moreover, the presence of SARS-CoV-2 RNA in exosomes suggests a potential route for viral spread.

FRONTIERS IN MOLECULAR BIOSCIENCES (2021)

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Review Immunology

Emerging roles of extracellular vesicles in COVID-19, a double-edged sword?

Xiaohuan Xia et al.

Summary: The sudden outbreak of COVID-19 originated from Wuhan, China, has become a global pandemic. Extracellular vesicles (EVs) play key roles in the pathogenesis and treatment of COVID-19, facilitating viral spreading and potential therapeutic interventions.

IMMUNOLOGY (2021)

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Review Biochemistry & Molecular Biology

Extracellular Vesicle-Based Therapy for COVID-19: Promises, Challenges and Future Prospects

Vamika Karn et al.

Summary: The COVID-19 pandemic has had a serious impact on public health and the economy, prompting an urgent need for effective therapeutic strategies. Extracellular vesicles (EVs) have shown promise in suppressing the cytokine storm and aiding in the recovery and treatment of COVID-19.

BIOMEDICINES (2021)

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Letter Critical Care Medicine

Prolonged enhancement of cytotoxic T lymphocytes in the post-recovery state of severe COVID-19

Yumi Mitsuyama et al.

Summary: Peripheral blood immune responses of lymphocytes in severe COVID-19 patients in different stages of recovery were evaluated using single-cell mass cytometry. Patients with prolonged hospitalization did not show recovery of B lymphocyte and CD4-positive T lymphocyte counts, but did show abundant CD8-positive T lymphocytes. Post-recovery patients had more CD4 and CD8 T cells expressing high levels of T-bet and Granzyme B. This study showed that cytotoxic Th1 and CD8 T cells are recruited to the peripheral blood long after recovery from COVID-19.

JOURNAL OF INTENSIVE CARE (2021)

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Article Medicine, General & Internal

Case Report: Administration of Amniotic Fluid-Derived Nanoparticles in Three Severely Ill COVID-19 Patients

Maria Ines Mitrani et al.

Summary: This study presented clinical outcomes of three critically ill patients treated with Zofin, demonstrating the safety and efficacy of Zofin in improving clinical status, respiratory function, and inflammatory biomarkers in patients suffering from COVID-19 induced respiratory failure.

FRONTIERS IN MEDICINE (2021)

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Review Health Care Sciences & Services

CD24 for Cardiovascular Researchers: A Key Molecule in Cardiac Immunology, Marker of Stem Cells and Target for Drug Development

Eyal Sagiv et al.

Summary: The membrane protein CD24 has emerged as a key player in various diseases, particularly cancer and immune modulation. Targeted drug development and the use of chimeric CD24-Fc protein have shown promising results in cancer treatment and clinical trials for auto-inflammatory syndromes. Further research on CD24 may lead to novel biological therapies for cardiovascular diseases.

JOURNAL OF PERSONALIZED MEDICINE (2021)

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Article Chemistry, Multidisciplinary

Tagged extracellular vesicles with the RBD of the viral spike protein for delivery of antiviral agents against SARS-COV-2 infection

Yuxuan Fu et al.

Summary: EVs can be recognized and endocytosed by tissue cells via specific interactions between surface membrane proteins, providing the potential for specific tissue targeting and drug delivery.

JOURNAL OF CONTROLLED RELEASE (2021)

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Article Cell & Tissue Engineering

Wharton's Jelly Mesenchymal Stem Cell-Derived Extracellular Vesicles Reduce SARS-CoV2-Induced Inflammatory Cytokines Under High Glucose and Uremic Toxin Conditions

Vuong Cat Khanh et al.

Summary: Cytokine storm is a major factor contributing to organ failures and mortality in COVID-19 patients. Patients with diabetes mellitus or renal disease experience more severe symptoms and higher mortality due to chronic inflammation. Recent research has explored the potential use of mesenchymal stem cells in modulating the immune response in COVID-19 patients. The study found that patients with both diabetes mellitus and renal disease have a higher risk of mortality, and high glucose and uremic toxins contribute to the induction of cytokine storm in response to the virus. Additionally, Wharton's jelly MSC-derived extracellular vesicles show promise in reducing cytokine storm reactions in patients with chronic inflammation and viral infection.

STEM CELLS AND DEVELOPMENT (2021)

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Review Immunology

Exosome-Based Vaccines: History, Current State, and Clinical Trials

Patrick Santos et al.

Summary: Extracellular vesicles play crucial roles in processes such as inflammation, cell proliferation, and immune response, while also being implicated in the pathogenesis of diseases like cancer and infectious diseases. Research suggests that EV-based vaccines have promising therapeutic potential for cancer and infectious diseases, showing exciting results in inducing immune responses.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Cell Biology

Extracellular vesicles carry SARS-CoV-2 spike protein and serve as decoys for neutralizing antibodies

Zach Troyer et al.

Summary: The spike protein of SARS-CoV-2 can be incorporated into extracellular vesicles (EVs) and act as decoy targets for neutralizing antibodies, reducing their effectiveness in blocking viral entry. This interplay between viruses, EVs, and the immune system has important implications for the pathogenesis of SARS-CoV-2 infection in vivo.

JOURNAL OF EXTRACELLULAR VESICLES (2021)

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Review Cell Biology

Development of Extracellular Vesicle Therapeutics: Challenges, Considerations, and Opportunities

Bethany Claridge et al.

Summary: Although EVs show great promise as therapeutic modalities due to their endogenous characteristics, further bioengineering refinement is needed to overcome clinical and commercial limitations. Clinical applications of EV-based therapeutics are diverse, including immunomodulation, tissue regeneration, and delivery vectors for combination therapies. Technologies such as imaging, quantitative analyses, and use of biocompatible natural sources for producing EVs will play a key role in overcoming limitations and advancing the field.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Review Biochemistry & Molecular Biology

The Potential Role of Extracellular Vesicles in COVID-19 Treatment: Opportunity and Challenge

Yan-yan Yan et al.

Summary: SARS-CoV-2 infection has become a global public health emergency, impacting society and the economy. Efforts worldwide are focused on developing vaccines and treatments. Emerging approaches, such as extracellular vesicles (EVs), are being explored to tackle the pandemic, offering potential treatment strategies like MSC-EVs, drug-EVs, vaccine-EVs, platelet-EVs, and others.

FRONTIERS IN MOLECULAR BIOSCIENCES (2021)

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Article Immunology

Persistent lymphopenia after diagnosis of COVID-19 predicts acute respiratory distress syndrome: A retrospective cohort study

Zhi-ye Zou et al.

Summary: This study found that persistent lymphopenia in patients with COVID-19 is associated with the occurrence of ARDS, as well as longer hospital stays. Further research is needed to explore whether immunostimulation of lymphocytes within 1 week can reduce the occurrence of ARDS.

EUROPEAN JOURNAL OF INFLAMMATION (2021)

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Review Biochemistry & Molecular Biology

The signal pathways and treatment of cytokine storm in COVID-19

Lan Yang et al.

Summary: The COVID-19 pandemic is a global crisis with devastating effects, where immunopathology plays a crucial role in disease progression, particularly the cytokine storm which has a significant impact on prognosis. Understanding and targeting the pathways involved in cytokine storm could lead to more effective treatment strategies for COVID-19.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

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Letter Medicine, General & Internal

Plasma Therapy to Prevent Severe Covid-19 in Older Adults

Fabio Klamt et al.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Review Surgery

Review the safety of Covid-19 mRNA vaccines: a review

Pratibha Anand et al.

Summary: Within the first year of the COVID-19 pandemic, over 100 million people globally have been infected, with a death toll surpassing 500,000 in the United States alone. The key to containing the pandemic lies in achieving herd immunity on a global scale, with at least 70-80% of the population needing to achieve active immunity against SARS-CoV-2.

PATIENT SAFETY IN SURGERY (2021)

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Article Cell & Tissue Engineering

Mesenchymal Stem Cell-Derived Extracellular Vesicles Carrying miRNA as a Potential Multi Target Therapy to COVID-19: an In Silico Analysis

Iago Carvalho Schultz et al.

Summary: The study suggests that MSC-derived EVs may have the potential to modulate exacerbated cytokines, cell death, and coagulation disturbances in severe COVID-19, thereby preventing tissue damage.

STEM CELL REVIEWS AND REPORTS (2021)

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Editorial Material Medicine, General & Internal

Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China Summary of a Report of 72 314 Cases From the Chinese Center for Disease Control and Prevention

Zunyou Wu et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2020)

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Review Immunology

The epidemiology and pathogenesis of coronavirus disease (COVID-19) outbreak

Hussin A. Rothan et al.

JOURNAL OF AUTOIMMUNITY (2020)

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Article Medicine, General & Internal

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

Chaolin Huang et al.

LANCET (2020)

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Article Multidisciplinary Sciences

A pneumonia outbreak associated with a new coronavirus of probable bat origin

Peng Zhou et al.

NATURE (2020)

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Article Medicine, General & Internal

A Novel Coronavirus from Patients with Pneumonia in China, 2019

Na Zhu et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Article Biochemistry & Molecular Biology

SARS-CoV-2 Reverse Genetics Reveals a Variable Infection Gradient in the Respiratory Tract

Yixuan J. Hou et al.

CELL (2020)

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Article Biochemistry & Molecular Biology

SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues

Carly G. K. Ziegler et al.

CELL (2020)

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Article Biochemistry & Molecular Biology

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

Markus Hoffmann et al.

CELL (2020)

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Article Immunology

Characterization of the receptor-binding domain (RBD) of 2019 novel coronavirus: implication for development of RBD protein as a viral attachment inhibitor and vaccine

Wanbo Tai et al.

CELLULAR & MOLECULAR IMMUNOLOGY (2020)

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Article Multidisciplinary Sciences

Cell entry mechanisms of SARS-CoV-2

Jian Shang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

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Article Multidisciplinary Sciences

Effectiveness of convalescent plasma therapy in severe COVID-19 patients

Kai Duan et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

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Article Cell & Tissue Engineering

Exosomes Derived from Bone Marrow Mesenchymal Stem Cells as Treatment for Severe COVID-19

Vikram Sengupta et al.

STEM CELLS AND DEVELOPMENT (2020)

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Letter Hematology

Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia

Deepa R. J. Arachchillage et al.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2020)

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Article Infectious Diseases

Expression of the SARS-CoV-2 cell receptor gene ACE2 in a wide variety of human tissues

Meng-Yuan Li et al.

INFECTIOUS DISEASES OF POVERTY (2020)

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Review Chemistry, Multidisciplinary

Structural and functional properties of SARS-CoV-2 spike protein: potential antivirus drug development for COVID-19

Yuan Huang et al.

ACTA PHARMACOLOGICA SINICA (2020)

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Editorial Material Medicine, Research & Experimental

Decoy ACE2-expressing extracellular vesicles that competitively bind SARS-CoV-2 as a possible COVID-19 therapy

Jameel M. Inal

CLINICAL SCIENCE (2020)

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Article Biochemistry & Molecular Biology

Analysis of the human breast milk microbiome and bacterial extracellular vesicles in healthy mothers

Su Yeong Kim et al.

EXPERIMENTAL AND MOLECULAR MEDICINE (2020)

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Review Infectious Diseases

The pathogenesis and treatment of the 'Cytokine Storm' in COVID-19

Qing Ye et al.

JOURNAL OF INFECTION (2020)

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Article Multidisciplinary Sciences

Structural basis for neutralization of SARS-CoV-2 and SARS-CoV by a potent therapeutic antibody

Zhe Lv et al.

SCIENCE (2020)

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Letter Immunology

Lymphopenia during the COVID-19 infection: What it shows and what can be learned

Soheil Tavakolpour et al.

IMMUNOLOGY LETTERS (2020)

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Review Biochemistry & Molecular Biology

A Review of Exosomal Isolation Methods: Is Size Exclusion Chromatography the Best Option?

Karim Sidhom et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Medicine, Research & Experimental

Potential inhibitors of the interaction between ACE2 and SARS-CoV-2 (RBD), to develop a drug

Claudia Guadalupe Benitez-Cardoza et al.

LIFE SCIENCES (2020)

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Review Cell Biology

Extracellular Vesicles as an Efficient and Versatile System for Drug Delivery

Xuan T. T. Dang et al.

CELLS (2020)

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Article Immunology

Natural history of COVID-19 and therapeutic options

Philippe Gautret et al.

EXPERT REVIEW OF CLINICAL IMMUNOLOGY (2020)

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Article Cell Biology

Extracellular vesicles containing ACE2 efficiently prevent infection by SARS-CoV-2 Spike protein-containing virus

Federico Cocozza et al.

JOURNAL OF EXTRACELLULAR VESICLES (2020)

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Editorial Material Nanoscience & Nanotechnology

Nanomedicine and the COVID-19 vaccines

[Anonymous]

NATURE NANOTECHNOLOGY (2020)

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Article Materials Science, Multidisciplinary

Calming Cytokine Storm in Pneumonia by Targeted Delivery of TPCA-1 Using Platelet-Derived Extracellular Vesicles

Qingle Ma et al.

MATTER (2020)

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Review Medicine, General & Internal

Novel COVID-19: A Comprehensive Review of Transmission, Manifestation, and Pathogenesis

Azhar Hussain et al.

CUREUS JOURNAL OF MEDICAL SCIENCE (2020)

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Review Immunology

Hypothesis for potential pathogenesis of SARS-CoV-2 infection-a review of immune changes in patients with viral pneumonia

Ling Lin et al.

EMERGING MICROBES & INFECTIONS (2020)

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Article Biochemistry & Molecular Biology

Reassessment of Exosome Composition

Dennis K. Jeppesen et al.

CELL (2019)

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Article Cell & Tissue Engineering

Mesenchymal stromal cell-derived nanovesicles ameliorate bacterial outer membrane vesicle-induced sepsis via IL-10

Kyong-Su Park et al.

STEM CELL RESEARCH & THERAPY (2019)

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Review Cell Biology

Mesenchymal Stem Cells for Regenerative Medicine

Yu Han et al.

CELLS (2019)

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Article Biochemistry & Molecular Biology

HIV-Nef Protein Persists in the Lungs of Aviremic Patients with HIV and Induces Endothelial Cell Death

Sarvesh Chelvanambi et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2019)

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Article Cell Biology

Specificities of secretion and uptake of exosomes and other extracellular vesicles for cell-to-cell communication

Mathilde Mathieu et al.

NATURE CELL BIOLOGY (2019)

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Article Medicine, Research & Experimental

Extracellular vesicles expressing a single-chain variable fragment of an HIV-1 specific antibody selectively target Env+ tissues

Xue Zou et al.

THERANOSTICS (2019)

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Review Biochemistry & Molecular Biology

Extracellular vesicle-based therapeutics: natural versus engineered targeting and trafficking

Daniel E. Murphy et al.

EXPERIMENTAL AND MOLECULAR MEDICINE (2019)

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Article Pharmacology & Pharmacy

CD24 and Fc fusion protein protects SIVmac239-infected Chinese rhesus macaque against progression to AIDS

Ren-Rong Tian et al.

ANTIVIRAL RESEARCH (2018)

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Article Oncology

Predicting the Presence of Oral Squamous Cell Carcinoma Using Commonly Dysregulated MicroRNA in Oral Swirls

Tami Yap et al.

CANCER PREVENTION RESEARCH (2018)

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Article Biotechnology & Applied Microbiology

The Impact of the CD9 Tetraspanin on Lentivirus Infectivity and Exosome Secretion

Kai O. Boker et al.

MOLECULAR THERAPY (2018)

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Article Virology

Human cytomegalovirus-infected cells release extracellular vesicles that carry viral surface proteins

Sonia Zicari et al.

VIROLOGY (2018)

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Article Cell Biology

Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines

Clotilde Thery et al.

JOURNAL OF EXTRACELLULAR VESICLES (2018)

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Article Biochemistry & Molecular Biology

Amyloid precursor protein products concentrate in a subset of exosomes specifically endocytosed by neurons

Karine Laulagnier et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2018)

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Article Cell Biology

Enrichment of extracellular vesicles from human synovial fluid using size exclusion chromatography

Andrew D. Foers et al.

JOURNAL OF EXTRACELLULAR VESICLES (2018)

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Article Biochemistry & Molecular Biology

A direct-imaging cryo-EM study of shedding extracellular vesicles from leukemic monocytes

Na'ama Koiffman et al.

JOURNAL OF STRUCTURAL BIOLOGY (2017)

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Article Oncology

Adipose-derived mesenchymal stem cells employed exosomes to attenuate AKI-CKD transition through tubular epithelial cell dependent Sox9 activation

Fengming Zhu et al.

ONCOTARGET (2017)

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Article Microbiology

The tetraspanin CD9 facilitates MERS-coronavirus entry by scaffolding host cell receptors and proteases

James T. Earnest et al.

PLOS PATHOGENS (2017)

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Article Cell Biology

Comprehensive toxicity and immunogenicity studies reveal minimal effects in mice following sustained dosing of extracellular vesicles derived from HEK293T cells

Xiaohua Zhu et al.

JOURNAL OF EXTRACELLULAR VESICLES (2017)

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Article Chemistry, Multidisciplinary

Virus-Mimetic Fusogenic Exosomes for Direct Delivery of Integral Membrane Proteins to Target Cell Membranes

Yoosoo Yang et al.

ADVANCED MATERIALS (2017)

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Article Microbiology

Dysregulated Type I Interferon and Inflammatory Monocyte-Macrophage Responses Cause Lethal Pneumonia in SARS-CoV-Infected Mice

Rudragouda Channappanavar et al.

CELL HOST & MICROBE (2016)

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Article Medicine, General & Internal

Epidemiology, Patterns of Care, and Mortality for Patients With Acute Respiratory Distress Syndrome in Intensive Care Units in 50 Countries

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JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2016)

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Extracellular vesicles and viruses: Are they close relatives?

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

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Article Cell & Tissue Engineering

Exosomal MicroRNAs Derived From Umbilical Mesenchymal Stem Cells Inhibit Hepatitis C Virus Infection

Xijing Qian et al.

STEM CELLS TRANSLATIONAL MEDICINE (2016)

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Article Multidisciplinary Sciences

Human Mesenchymal stem cells program macrophage plasticity by altering their metabolic status via a PGE2-dependent mechanism

Anoop Babu Vasandan et al.

SCIENTIFIC REPORTS (2016)

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Article Cell Biology

CD24: A Rheostat That Modulates Cell Surface Receptor Signaling of Diverse Receptors

D. Craig Ayre et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2016)

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Article Biochemistry & Molecular Biology

Small RNA deep sequencing discriminates subsets of extracellular vesicles released by melanoma cells - Evidence of unique microRNA cargos

Taral R. Lunavat et al.

RNA BIOLOGY (2015)

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Article Respiratory System

Human mesenchymal stromal cells decrease the severity of acute lung injury induced by E. coli in the rat

James Devaney et al.

THORAX (2015)

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Article Multidisciplinary Sciences

A novel mechanism of generating extracellular vesicles during apoptosis via a beads-on-a-string membrane structure

Georgia K. Atkin-Smith et al.

NATURE COMMUNICATIONS (2015)

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Article Engineering, Biomedical

A doxorubicin delivery platform using engineered natural membrane vesicle exosomes for targeted tumor therapy

Yanhua Tian et al.

BIOMATERIALS (2014)

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Article Urology & Nephrology

Characterization and deep sequencing analysis of exosomal and non-exosomal miRNA in human urine

Lesley Cheng et al.

KIDNEY INTERNATIONAL (2014)

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Unexpected link between an antibiotic, pannexin channels and apoptosis

Ivan K. H. Poon et al.

NATURE (2014)

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Review Immunology

Tetraspanins in extracellular vesicle formation and function

Zoraida Andreu et al.

FRONTIERS IN IMMUNOLOGY (2014)

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Article Hematology

Endothelial cells require miR-214 to secrete exosomes that suppress senescence and induce angiogenesis in human and mouse endothelial cells

Bas W. M. van Balkom et al.

BLOOD (2013)

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Article Biochemical Research Methods

Oncogenic H-Ras Reprograms Madin-Darby Canine Kidney (MDCK) Cell-derived Exosomal Proteins Following Epithelial-Mesenchymal Transition

Bow J. Tauro et al.

MOLECULAR & CELLULAR PROTEOMICS (2013)

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Article Cell & Tissue Engineering

Microvesicles Derived from Human Bone Marrow Mesenchymal Stem Cells Inhibit Tumor Growth

Stefania Bruno et al.

STEM CELLS AND DEVELOPMENT (2013)

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Article Cell Biology

Distinct RNA profiles in subpopulations of extracellular vesicles: apoptotic bodies, microvesicles and exosomes

Rossella Crescitelli et al.

JOURNAL OF EXTRACELLULAR VESICLES (2013)

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Article Biochemistry & Molecular Biology

Apoptotic cell-derived ICAM-3 promotes both macrophage chemoattraction to and tethering of apoptotic cells

E. E. Torr et al.

CELL DEATH AND DIFFERENTIATION (2012)

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Article Biochemistry & Molecular Biology

Prion-infected cells regulate the release of exosomes with distinct ultrastructural features

Bradley M. Coleman et al.

FASEB JOURNAL (2012)

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Review Immunology

Beginnings of a Good Apoptotic Meal: The Find-Me and Eat-Me Signaling Pathways

Kodi S. Ravichandran

IMMUNITY (2011)

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Article Biotechnology & Applied Microbiology

Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

Lydia Alvarez-Erviti et al.

NATURE BIOTECHNOLOGY (2011)

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Molecular and clinical dissection of CD24 antibody specificity by a comprehensive comparative analysis

Glen Kristiansen et al.

LABORATORY INVESTIGATION (2010)

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Molecular mechanism of multivesicular body biogenesis by ESCRT complexes

Thomas Wollert et al.

NATURE (2010)

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Review Cell Biology

Mesenchymal stem cell-based therapy: a new paradigm in regenerative medicine

Neeraj Kumar Satija et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2009)

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CD24 and Siglec-10 Selectively Repress Tissue Damage-Induced Immune Responses

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SCIENCE (2009)

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Review Biotechnology & Applied Microbiology

Anti-inflammatory effects of mesenchymal stem cells: novel concept for future therapies

Smita S. Iyer et al.

EXPERT OPINION ON BIOLOGICAL THERAPY (2008)

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Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers

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NATURE CELL BIOLOGY (2008)

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Review Hematology

Circulating microparticles: pathophysiology and clinical implications

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BLOOD REVIEWS (2007)

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Article Cell Biology

Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells

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NATURE CELL BIOLOGY (2007)

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Article Cardiac & Cardiovascular Systems

Bone marrow stem cells prevent left ventricular remodeling of ischemic heart through paracrine signaling

Ryota Uemura et al.

CIRCULATION RESEARCH (2006)

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Article Cell Biology

A novel role for microtubules in apoptotic chromatin dynamics and cellular fragmentation

David K. Moss et al.

JOURNAL OF CELL SCIENCE (2006)

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Article Cell Biology

Active relocation of chromatin and endoplasmic reticulum into blebs in late apoptotic cells

JD Lane et al.

JOURNAL OF CELL SCIENCE (2005)

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Siglec-5 (CD170) can mediate inhibitory signaling in the absence of immunoreceptor tyrosine-based inhibitory motif phosphorylation

T Avril et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2005)

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