期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 23, 期 19, 页码 -出版社
MDPI
DOI: 10.3390/ijms231911247
关键词
extracellular vesicles; COVID-19; SARS-CoV-2; exosomes; therapeutics; vaccine
资金
- National Research Foundation of Korea (NRF) - Korean government (MSIT: Ministry of Science, ICR & Future Planning) [2022R1A2C2003413]
- Korean Health Technology R&D Project through the Korean Health Industry Development Institute (KHIDI) - Ministry of Health & Welfare, Republic of Korea [HV22C0073]
- Korea Basic Science Institute (National Research Facilities and Equipment Center) grant - Ministry of Education [2019R1A6C1010003]
- National Research Foundation of Korea [2022R1A2C2003413] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
The COVID-19 pandemic has had a significant impact on people worldwide, affecting various aspects of life. Extracellular vesicles have emerged as a potential therapeutic and vaccine development tool against COVID-19, but there are obstacles to their clinical use that need to be addressed.
The COVID-19 pandemic has had a deep impact on people worldwide since late 2019 when SARS-CoV-2 was first identified in Wuhan, China. In addition to its effect on public health, it has affected humans in various aspects of life, including social, economic, cultural, and political. It is also true that researchers have made vigorous efforts to overcome COVID-19 throughout the world, but they still have a long way to go. Accordingly, innumerable therapeutics and vaccine candidates have been studied for their efficacies and have been tried clinically in a very short span of time. For example, the versatility of extracellular vesicles, which are membrane-bound particles released from all types of cells, have recently been highlighted in terms of their effectiveness, biocompatibility, and safety in the fight against COVID-19. Thus, here, we tried to explain the use of extracellular vesicles as therapeutics and for the development of vaccines against COVID-19. Along with the mechanisms and a comprehensive background of their application in trapping the coronavirus or controlling the cytokine storm, we also discuss the obstacles to the clinical use of extracellular vesicles and how these could be resolved in the future.
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