期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 23, 期 18, 页码 -出版社
MDPI
DOI: 10.3390/ijms231810460
关键词
energy expenditure; thermogenesis; meta-inflammation; obesity; pomegranate extract
资金
- Regional Government of Community of Madrid [IND2017/BIO-7826, P2018/BAA-4343-ALIBIRD2020-CM]
- Ministerio de Ciencia e Innovacion, Spain [PID2019110183RB-C21]
- Ramon Areces Foundation [CIVP19A5937]
- EU Structural Funds
- COST Action [CA17118]
- Synergistic Projects Community of Madrid [NUTRISION-CM/Y2020/BIO-6350]
- REACT EU Program (Comunidad de Madrid)
- European Regional Development Fund
- ERDF
- European Union-FACINGLCOVID-CM project
Obesity is associated with chronic inflammation and metabolic disorders. A Mediterranean diet and pomegranate extract (PomE) can reduce inflammation and improve metabolic symptoms.
Obesity is associated to a low grade of chronic inflammation leading to metabolic stress, insulin resistance, metabolic syndrome, dislipidemia, cardiovascular disease, and even cancer. A Mediterranean diet has been shown to reduce systemic inflammatory factors, insulin resistance, and metabolic syndrome. In this scenario, precision nutrition may provide complementary approaches to target the metabolic alterations associated to unhealthy obesity. In a previous work, we described a pomegranate extract (PomE) rich in punicalagines to augment markers of browning and thermogenesis in human differentiated adipocytes and to augment the oxidative respiratory capacity in human differentiated myocytes. Herein, we have conducted a preclinical study of high-fat-diet (HFD)-induced obesity where PomE augments the systemic energy expenditure (EE) contributing to a reduction in the low grade of chronic inflammation and insulin resistance associated to obesity. At the molecular level, PomE promotes browning and thermogenesis in adipose tissue, reducing inflammatory markers and augmenting the reductive potential to control the oxidative stress associated to the HFD. PomE merits further investigation as a complementary approach to alleviate obesity, reducing the low grade of chronic inflammation and metabolic stress.
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