4.7 Review

The Interplay between Ghrelin and Microglia in Neuroinflammation: Implications for Obesity and Neurodegenerative Diseases

期刊

出版社

MDPI
DOI: 10.3390/ijms232113432

关键词

Ghrelin; Ghrelin receptor; microglia; inflammation; neuroinflammation; neurodegenerative diseases; Alzheimer's disease; Parkinson's disease

向作者/读者索取更多资源

Numerous studies have shown that microglia play a role in promoting inflammatory processes within the central nervous system by producing chemokines. These cells share similarities with macrophages, suggesting they are involved in innate immune responses in the brain. Neuroinflammation leads to changes in neuro-metabolism and increased energy consumption. Recent research has focused on the role of Ghre signaling in microglia activity and its impact on neurodegenerative diseases. Understanding this role could provide strategies to downregulate neuroinflammation and reduce negative neurological outcomes.
Numerous studies have shown that microglia are capable of producing a wide range of chemokines to promote inflammatory processes within the central nervous system (CNS). These cells share many phenotypical and functional characteristics with macrophages, suggesting that microglia participate in innate immune responses in the brain. Neuroinflammation induces neurometabolic alterations and increases in energy consumption. Microglia may constitute an important therapeutic target in neuroinflammation. Recent research has attempted to clarify the role of Ghre signaling in microglia on the regulation of energy balance, obesity, neuroinflammation and the occurrence of neurodegenerative diseases. These studies strongly suggest that Ghre modulates microglia activity and thus affects the pathophysiology of neurodegenerative diseases. This review aims to summarize what is known from the current literature on the way in which Ghre modulates microglial activity during neuroinflammation and their impact on neurometabolic alterations in neurodegenerative diseases. Understanding the role of Ghre in microglial activation/inhibition regulation could provide promising strategies for downregulating neuroinflammation and consequently for diminishing negative neurological outcomes.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据