4.7 Article

The Binding of CSL Proteins to Either Co-Activators or Co-Repressors Protects from Proteasomal Degradation Induced by MAPK-Dependent Phosphorylation

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Oncology

RITA1 drives the growth of bladder cancer cells by recruiting TRIM25 to facilitate the proteasomal degradation of RBPJ

Huancheng Tang et al.

Summary: The study reveals the crucial role of RITA1 in promoting the growth of bladder cancer cells through the RITA1/TRIM25/RBPJ axis, providing a potential therapeutic target for bladder cancer.

CANCER SCIENCE (2022)

Article Cell Biology

TRIM25 regulates oxaliplatin resistance in colorectal cancer by promoting EZH2 stability

Sha Zhou et al.

Summary: TRIM25 is identified as an epigenetic regulator of oxaliplatin resistance in colorectal cancer patients, affecting disease-free survival and recurrence rates. Its overexpression promotes stem cell properties in CRC cells and resistance to chemotherapy. Targeting TRIM25 may be a potential strategy for managing OXA resistance in clinical practice.

CELL DEATH & DISEASE (2021)

Article Genetics & Heredity

Nucleo-cytoplasmic shuttling of murine RBPJ by Hairless protein matches that of Su(H) protein in the model system Drosophila melanogaster

Dorina B. Wolf et al.

Summary: CSL transcription factors play crucial roles in the Notch signaling pathway by inducing activation or repression of Notch target genes through recruiting specific cofactors. Research in fruit flies and mice has revealed that CSL homologues depend on cofactors for nuclear entry and exhibit dynamic nucleo-cytoplasmic shuttling.

HEREDITAS (2021)

Article Cell Biology

Phospho-Site Mutations in Transcription Factor Suppressor of Hairless Impact Notch Signaling Activity During Hematopoiesis in Drosophila

Lisa Frankenreiter et al.

Summary: The study reveals a novel mechanism of tissue-specific Notch regulation involving phosphorylation of CSL transcription factors in the DNA-binding domain. Findings in fruit flies and mammalian cells suggest a potential conservation of this phosphorylation regulatory mechanism, providing a means to fine-tune Notch signal transduction in a context-dependent manner.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

Review Cell Biology

Decoding the Notch signal

Julia Falo-Sanjuan et al.

DEVELOPMENT GROWTH & DIFFERENTIATION (2020)

Review Biochemistry & Molecular Biology

Decoding the PTM-switchboard of Notch

Daniel Antfolk et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2019)

Review Biochemistry & Molecular Biology

The Hunt for Degrons of the 26S Proteasome

Hadar Ella et al.

BIOMOLECULES (2019)

Article Cell Biology

Dynamics of Notch-Dependent Transcriptional Bursting in Its Native Context

ChangHwan Lee et al.

DEVELOPMENTAL CELL (2019)

Article Cell Biology

Enhancer Priming Enables Fast and Sustained Transcriptional Responses to Notch Signaling

Julia Falo-Sanjuan et al.

DEVELOPMENTAL CELL (2019)

Review Medicine, Research & Experimental

Structurally conserved binding motifs of transcriptional regulators to notch nuclear effector CSL

Daniel P. Hall et al.

EXPERIMENTAL BIOLOGY AND MEDICINE (2019)

Article Biochemistry & Molecular Biology

Nucleo-cytoplasmic shuttling of Drosophila Hairless/Su(H) heterodimer as a means of regulating Notch dependent transcription

Donna Wolf et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2019)

Review Biochemistry & Molecular Biology

The Roles of Notch Signaling in Liver Development and Disease

Joshua M. Adams et al.

BIOMOLECULES (2019)

Article Cell Biology

Activation of the Notch Signaling Pathway In Vivo Elicits Changes in CSL Nuclear Dynamics

Maria J. Gomez-Lamarca et al.

DEVELOPMENTAL CELL (2018)

Article Biochemistry & Molecular Biology

UbiSite approach for comprehensive mapping of lysine and N-terminal ubiquitination sites

Vyacheslav Akimov et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2018)

Article Biochemistry & Molecular Biology

UbiSite approach for comprehensive mapping of lysine and N-terminal ubiquitination sites

Vyacheslav Akimov et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2018)

Review Physiology

NOTCH SIGNALING IN DEVELOPMENT, TISSUE HOMEOSTASIS, AND DISEASE

Chris Siebel et al.

PHYSIOLOGICAL REVIEWS (2017)

Article Multidisciplinary Sciences

Phosphorylation of Suppressor of Hairless impedes its DNA-binding activity

Anja C. Nagel et al.

SCIENTIFIC REPORTS (2017)

Review Cell Biology

Notch signalling in context

Sarah J. Bray

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2016)

Article Cell Biology

Identification of a Paralog-Specific Notch1 Intracellular Domain Degron

Matthew R. Broadus et al.

CELL REPORTS (2016)

Review Cell Biology

The Role of Notch Receptors in Transcriptional Regulation

Hongfang Wang et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2015)

Article Multidisciplinary Sciences

Substrate degradation by the proteasome: A single-molecule kinetic analysis

Ying Lu et al.

SCIENCE (2015)

Article Biochemistry & Molecular Biology

PhosphoSitePlus, 2014: mutations, PTMs and recalibrations

Peter V. Hornbeck et al.

NUCLEIC ACIDS RESEARCH (2015)

Article Oncology

From Fly Wings to Targeted Cancer Therapies: A Centennial for Notch Signaling

Panagiotis Ntziachristos et al.

CANCER CELL (2014)

Article Genetics & Heredity

Analysis of the interaction between human RITA and Drosophila Suppressor of Hairless

Birgit Brockmann et al.

HEREDITAS (2014)

Article Multidisciplinary Sciences

NOTCH1-RBPJ complexes drive target gene expression through dynamic interactions with superenhancers

Hongfang Wang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Article Biochemistry & Molecular Biology

Structure and Function of the CSL-KyoT2 Corepressor Complex: A Negative Regulator of Notch Signaling

Kelly J. Collins et al.

STRUCTURE (2014)

Review Oncology

Notch- EGFR/ HER2bidirectionalcrosstalkinbreastcancer

Andrew T. Baker et al.

FRONTIERS IN ONCOLOGY (2014)

Article Cell Biology

Dynamic binding of RBPJ is determined by Notch signaling status

David Castel et al.

GENES & DEVELOPMENT (2013)

Article Cell Biology

Notch signaling at a glance

Kazuya Hori et al.

JOURNAL OF CELL SCIENCE (2013)

Article Biochemical Research Methods

Proteomic Analyses Reveal Divergent Ubiquitylation Site Patterns in Murine Tissues

Sebastian A. Wagner et al.

MOLECULAR & CELLULAR PROTEOMICS (2012)

Review Cell Biology

Notch and disease: A growing field

Angeliki Louvi et al.

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2012)

Article Biochemistry & Molecular Biology

Transcriptional Repression in the Notch Pathway THERMODYNAMIC CHARACTERIZATION OF CSL-MINT (Msx2-INTERACTING NUCLEAR TARGET PROTEIN) COMPLEXES

Bradley D. VanderWielen et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2011)

Article Biochemistry & Molecular Biology

Thermodynamic and structural insights into CSL-DNA complexes

David R. Friedmann et al.

PROTEIN SCIENCE (2010)

Review Biochemistry & Molecular Biology

Identification, analysis, and prediction of protein ubiquitination sites

Predrag Radivojac et al.

PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS (2010)

Review Biochemistry & Molecular Biology

The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism

Raphael Kopan et al.

Review Biochemistry & Molecular Biology

The Notch signaling pathway: Transcriptional regulation at Notch target genes

T. Borggrefe et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2009)

Article Biochemistry & Molecular Biology

RAM-induced allostery facilitates assembly of a Notch pathway active transcription complex

David R. Friedmann et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2008)

Article Multidisciplinary Sciences

An optimized transgenesis system for Drosophila using germ-line-specific φC31 integrases

Johannes Bischof et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

Review Cell Biology

Crossing paths with Notch in the hyper-network

Gregory D. Hurlbut et al.

CURRENT OPINION IN CELL BIOLOGY (2007)

Article Biochemistry & Molecular Biology

Crystal structure of the CSL-Notch-Mastermind ternary complex bound to DNA

JJ Wilson et al.

Article Genetics & Heredity

Hairless: the ignored antagonist of the Notch signalling pathway

Dieter Maier

HEREDITAS (2006)

Review Cell Biology

Notch signalling: a simple pathway becomes complex

Sarah J. Bray

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2006)

Article Biochemistry & Molecular Biology

Hairless-mediated repression of Notch target genes requires the combined activity of Groucho and CtBP corepressors

AC Nagel et al.

MOLECULAR AND CELLULAR BIOLOGY (2005)

Review Cell Biology

The love-hate relationship between Ras and Notch

MV Sundaram

GENES & DEVELOPMENT (2005)

Article Cell Biology

Bre1 is required for notch signaling and histone modification

S Bray et al.

DEVELOPMENTAL CELL (2005)

Review Cell Biology

Proteolysis: from the lysosome to ubiquitin and the proteasome

A Ciechanover

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2005)

Article Biochemistry & Molecular Biology

Proteasomal ATPases link ubiquitylation of histone H2B to methylation of histone H3

E Ezhkova et al.

MOLECULAR CELL (2004)

Article Biochemistry & Molecular Biology

Mastermind recruits CycC:CDK8 to phosphorylate the notch ICD and coordinate activation with turnover

CJ Fryer et al.

MOLECULAR CELL (2004)

Review Cell Biology

How the ubiquitin-proteasome system controls transcription

M Muratani et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2003)

Review Biochemistry & Molecular Biology

Protein degradation: Four E3s for the Notch pathway

EC Lai

CURRENT BIOLOGY (2002)

Article Biochemistry & Molecular Biology

Nuclear localization of CBF1 is regulated by interactions with the SMRT corepressor complex

SF Zhou et al.

MOLECULAR AND CELLULAR BIOLOGY (2001)

Article Biochemistry & Molecular Biology

Notch pathway: Making sense of suppressor of hairless

S Bray et al.

CURRENT BIOLOGY (2001)