4.7 Article

PTEN Loss Enhances Error-Prone DSB Processing and Tumor Cell Radiosensitivity by Suppressing RAD51 Expression and Homologous Recombination

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Genetics & Heredity

Catch them if you are aware: PTEN postzygotic mosaicism in clinically suspicious patients with PTEN Hamartoma Tumour Syndrome and literature review

Linda A. J. Hendricks et al.

Summary: This article describes two cases of PTEN mosaicism, suggesting that it may be more common than currently reported. Awareness of PTEN mosaicism is crucial for timely diagnosis and inclusion in cancer surveillance programs, ultimately improving prognosis and life expectancy for affected individuals.

EUROPEAN JOURNAL OF MEDICAL GENETICS (2022)

Review Cell Biology

The non-canonical nuclear functions of key players of the PI3K-AKT-MTOR pathway

Sakshi Gupta et al.

Summary: The PI3K-AKT-MTOR signaling pathway is essential for various cellular functions and has been found to be involved in nuclear processes such as DNA replication, transcription, DNA repair, maintenance of genomic integrity, chromatin architecture, and cell cycle control. Effector molecules of this pathway can translocate to the nucleus and regulate nuclear signaling.

JOURNAL OF CELLULAR PHYSIOLOGY (2022)

Review Cell Biology

Cell cycle control in cancer

Helen K. Matthews et al.

Summary: This review highlights the importance of cell cycle regulation in preventing genetic errors and cell proliferation, and how disruption of these mechanisms is associated with cancer development. Cancer arises from continuous cell division and evasion of cell cycle control mechanisms.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2022)

Review Endocrinology & Metabolism

PTEN-PI3K pathway alterations in advanced prostate cancer and clinical implications

Atish D. Choudhury

Summary: Despite significant advances in molecular characterization and therapeutic targeting, prostate cancer remains a major cause of cancer death in the US. The PI3K/AKT/mTOR signaling pathway is commonly altered in prostate cancer, with clinical trials of pathway inhibitors demonstrating modest activity. Challenges include toxicities from noncancerous tissue signaling and the need for rational combinations and biomarker selection to optimize therapeutic benefit.

PROSTATE (2022)

Article Dermatology

Cowden Disease: A Review

Mario Magaña et al.

AMERICAN JOURNAL OF DERMATOPATHOLOGY (2022)

Article Oncology

Identification of distinct genomic features reveals frequent somatic AHNAK and PTEN mutations predominantly in primary malignant melanoma presenting in the ureter

Yan Huang et al.

Summary: This study provides the first evidence that different genetic variations may contribute to the distinct phenotypes of primary malignant melanoma of the ureter. Primary malignant melanoma of the urinary tract has a poorer prognosis compared to primary urothelial carcinoma.

JAPANESE JOURNAL OF CLINICAL ONCOLOGY (2022)

Review Genetics & Heredity

Non-canonical function of nuclear PTEN and its implication on tumorigenesis

Sandip Misra et al.

Summary: PTEN is a critical tumor suppressor protein with distinct functions in the nucleus and cytoplasm, requiring further research into its regulatory mechanisms. Loss or mutation of PTEN is associated with tumor development in various tissues.

DNA REPAIR (2021)

Article Genetics & Heredity

Proficiency in homologous recombination repair is prerequisite for activation of G2-checkpoint at low radiation doses

Aashish Soni et al.

Summary: The repair pathways of DNA double strand breaks (DSBs) collaborate with DNA damage cell cycle checkpoints to protect genomic stability in cells exposed to ionizing radiation. Checkpoints are known to facilitate the function of DSB repair pathways, but the feedback of DSB repair proficiency into checkpoint activation has been less investigated. In cells deficient in homologous recombination repair (HRR), the activation of the G(2)-checkpoint is severely impaired after exposure to low IR doses in the G(2)-phase. This shows the close intertwining of HRR and the ATM/ATR-dependent G(2)-checkpoint in cells exposed to low IR-doses in G(2)-phase, indicating that HRR dominates in this context.

DNA REPAIR (2021)

Review Oncology

PTEN Hamartoma Tumor Syndrome/Cowden Syndrome: Genomics, Oncogenesis, and Imaging Review for Associated Lesions and Malignancy

David D. Dragoo et al.

Summary: Cancer types commonly seen in Cowden syndrome patients include benign tumors like Lhermitte-Duclos disease and malignant tumors involving the breast, thyroid, kidneys, and uterus. Understanding the imaging findings of these tumors can help in early tumor recognition and improve patient survival rates.

CANCERS (2021)

Article Biochemistry & Molecular Biology

Strong suppression of gene conversion with increasing DNA double-strand break load delimited by 53BP1 and RAD52

Emil Mladenov et al.

NUCLEIC ACIDS RESEARCH (2020)

Review Biochemistry & Molecular Biology

How Cells Respond to DNA Breaks in Mitosis

Andrew N. Blackford et al.

TRENDS IN BIOCHEMICAL SCIENCES (2020)

Review Biochemistry & Molecular Biology

Limiting the DNA Double-Strand Break Resectosome for Genome Protection

Daryl A. Ronato et al.

TRENDS IN BIOCHEMICAL SCIENCES (2020)

Article Biochemistry & Molecular Biology

Poly(ADP-ribosyl)ation by PARP1: reaction mechanism and regulatory proteins

Elizaveta E. Alemasova et al.

NUCLEIC ACIDS RESEARCH (2019)

Review Oncology

Mechanisms of PTEN loss in cancer: It's all about diversity

Virginia Alvarez-Garcia et al.

SEMINARS IN CANCER BIOLOGY (2019)

Article Oncology

PTEN Regulates Nonhomologous End Joining By Epigenetic Induction of NHEJ1/XLF

Parker L. Sulkowski et al.

MOLECULAR CANCER RESEARCH (2018)

Review Cell Biology

The control of DNA repair by the cell cycle

Nicole Hustedt et al.

NATURE CELL BIOLOGY (2017)

Review Multidisciplinary Sciences

PARP inhibitors: Synthetic lethality in the clinic

Christopher J. Lord et al.

SCIENCE (2017)

Article Oncology

PARG deficiency is neither synthetic lethal with BRCA1 nor PTEN deficiency

Aurelia Noll et al.

CANCER CELL INTERNATIONAL (2016)

Review Biochemistry & Molecular Biology

PTEN

Carolyn A. Worby et al.

ANNUAL REVIEW OF BIOCHEMISTRY, VOL 83 (2014)

Article Multidisciplinary Sciences

Nuclear PTEN Controls DNA Repair and Sensitivity to Genotoxic Stress

C. Bassi et al.

SCIENCE (2013)

Editorial Material Oncology

Does PTEN Loss Impair DNA Double-Strand Break Repair by Homologous Recombination?

Clayton R. Hunt et al.

CLINICAL CANCER RESEARCH (2012)

Article Biochemistry & Molecular Biology

Homologous recombination and its regulation

Lumir Krejci et al.

NUCLEIC ACIDS RESEARCH (2012)

Article Biochemistry & Molecular Biology

NADPH Oxidase 1 Modulates WNT and NOTCH1 Signaling To Control the Fate of Proliferative Progenitor Cells in the Colon

Nicolas Coant et al.

MOLECULAR AND CELLULAR BIOLOGY (2010)

Article Cell Biology

PTEN Deficiency in Endometrioid Endometrial Adenocarcinomas Predicts Sensitivity to PARP Inhibitors

Konstantin J. Dedes et al.

SCIENCE TRANSLATIONAL MEDICINE (2010)

Article Medicine, Research & Experimental

Synthetic lethal targeting of PTEN mutant cells with PARP inhibitors

Ana M. Mendes-Pereira et al.

EMBO MOLECULAR MEDICINE (2009)

Article Biochemistry & Molecular Biology

Essential role for nuclear PTEN in maintaining chromosomal integrity

Wen Hong Shen et al.

Article Multidisciplinary Sciences

Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

H Farmer et al.

NATURE (2005)

Article Biochemistry & Molecular Biology

Transient strong reduction of PTEN expression by specific RNAi induces loss of adhesion of the cells

S Mise-Omata et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2005)

Review Biochemistry & Molecular Biology

Akt/PKB signaling mechanisms in cancer and chemoresistance

D Kim et al.

FRONTIERS IN BIOSCIENCE-LANDMARK (2005)

Article Oncology

The biology and clinical relevance of the PTEN tumor suppressor pathway

I Sansal et al.

JOURNAL OF CLINICAL ONCOLOGY (2004)

Article Biochemistry & Molecular Biology

Bisperoxovanadium compounds are potent PTEN inhibitors

AC Schmid et al.

FEBS LETTERS (2004)

Review Biochemistry & Molecular Biology

Rad51 recombinase and recombination mediators

P Sung et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2003)