4.7 Review

On the Relevance of Soft Tissue Sarcomas Metabolic Landscape Mapping

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Oncology

Proteomic and Metabolomic Profiling in Soft Tissue Sarcomas

Madhumeeta Chadha et al.

Summary: Advances in proteomic and metabolomic technologies have greatly contributed to our understanding of cancer biology, including the identification of new drug targets and biomarkers. The use of these technologies in soft tissue sarcoma research shows promising potential, but further integration with other omics strategies and clinical trials is needed to maximize their impact.

CURRENT TREATMENT OPTIONS IN ONCOLOGY (2022)

Article Genetics & Heredity

Ribonucleotide reductase subunit M2 is a potential prognostic marker and therapeutic target for soft tissue sarcoma

Basudeb Das et al.

Summary: A potential oncogene RRM2 associated with soft tissue sarcoma prognosis was identified, with high RRM2 expression linked to lower survival rates in patients.
Review Biotechnology & Applied Microbiology

Targeting cancer metabolism in the era of precision oncology

Zachary E. Stine et al.

Summary: In the past century, there have been significant advancements in targeting cancer metabolism, but progress in the past decade has been limited. Some metabolism-based drugs for cancer have been successfully developed and are in clinical trials. However, consideration of the metabolism of non-cancer cells is crucial for successful treatment of cancer.

NATURE REVIEWS DRUG DISCOVERY (2022)

Article Multidisciplinary Sciences

Clinical sequencing of soft tissue and bone sarcomas delineates diverse genomic landscapes and potential therapeutic targets

Benjamin A. Nacev et al.

Summary: Sarcomas are rare tumors with diverse genetic features and clinical outcomes. This study analyzes over 2000 sarcomas across 45 subtypes and identifies distinct genomic groups that differ from histological subgroups. The complex genetic heterogeneity of sarcomas makes it challenging to identify therapeutic targets and advance patient care. The findings of this study provide valuable insights into subtype-specific genetic alterations and will contribute to the improvement of sarcoma models and further investigations of genetic factors and treatment responses.

NATURE COMMUNICATIONS (2022)

Review Oncology

Application of Multi-Omics Approach in Sarcomas: A Tool for Studying Mechanism, Biomarkers, and Therapeutic Targets

Zijian Zou et al.

Summary: Sarcomas are rare mesenchymal neoplasms with unique genetic characteristics, and their diagnosis relies heavily on pathological examination. Advanced treatments and multi-omics approaches have shown promise in improving outcomes and understanding sarcomas, but further research is needed to optimize their clinical application.

FRONTIERS IN ONCOLOGY (2022)

Article Oncology

Her4 promotes cancer metabolic reprogramming via the c-Myc-dependent signaling axis

Jing Han et al.

Summary: This study identified a critical role of Her4 in rewiring cancer metabolism towards tumor-promoting processes, potentially through the regulation of c-Myc stability. Overexpression of Her4 was found to increase glucose uptake and promote tumor growth, shedding light on the involvement of Her4 in tumorigenesis. These findings suggest promising opportunities for targeted metabolic therapy in cancer treatment.

CANCER LETTERS (2021)

Review Cell Biology

The Evolving Landscape of Noncanonical Functions of Metabolic Enzymes in Cancer and Other Pathologies

Daqian Xu et al.

Summary: Key pathological signaling pathways regulate metabolic enzymes, giving them nonmetabolic functions. These aberrantly regulated metabolic enzymes play critical roles in governing cellular activities, promoting disease progression.

CELL METABOLISM (2021)

Article Genetics & Heredity

Identification of a survival-related signature for sarcoma patients through integrated transcriptomic and proteomic profiling analyses

Biyu Zhang et al.

Summary: The prognostic signature integrating proteomic and transcriptomic profiles can be used to predict outcomes for SARC patients, with potential clinical value and biomarkers, revealing insights into molecular mechanisms and immune landscapes.
Article Medicine, Research & Experimental

Multi-omics analysis of copy number variations of RNA regulatory genes in soft tissue sarcoma

Xiaoshuai Wang et al.

Summary: RNA regulatory genes exhibit copy number variations in soft tissue sarcomas, with diploid copy number of METTL4 being associated with patient survival, immune infiltration, and DNA methylation. Drug sensitivity analysis reveals Temozolomide and Olaparib as effective treatments for soft tissue sarcomas with loss CN of METTL4.

LIFE SCIENCES (2021)

Article Multidisciplinary Sciences

Time-resolved non-invasive metabolomic monitoring of a single cancer spheroid by microfluidic NMR

Bishnubrata Patra et al.

Summary: The study utilized a micro-NMR platform to observe metabolic changes in a single spheroid culture of human cancer cells, revealing interesting findings such as linear monitoring of cell numbers and differences in metabolic rates between spheroids and monolayer cultures.

SCIENTIFIC REPORTS (2021)

Article Genetics & Heredity

Development and validation of prognostic markers in sarcomas base on a multi-omics analysis

Yongchun Song et al.

Summary: The comprehensive analysis of genomic and epigenomic regulation in sarcomas provides new insights into multilayered pathobiology. The four molecular subtypes and three prognostic markers developed in this study improve the current understanding of the molecular mechanisms underlying sarcomas.

BMC MEDICAL GENOMICS (2021)

Article Oncology

Metabolomics in cancer research and emerging applications in clinical oncology

Daniel R. Schmidt et al.

Summary: Cancer has complex effects on cellular and systemic metabolism, with metabolomics playing a crucial role in providing insights for cancer diagnosis, monitoring, and therapy. Advances in technology have expanded the applications of metabolomics in clinical research, with the potential to further enhance cancer patient management in the future.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

Review Biochemistry & Molecular Biology

Recent Metabolomics Analysis in Tumor Metabolism Reprogramming

Jingjing Han et al.

Summary: Metabolomic analysis is a powerful tool for monitoring dynamic changes in tumor metabolism and response to treatment. It can help identify early biomarkers of cancer development, predict individual responses to cancer drugs, assess drug efficacy, and monitor drug resistance. Stable isotope tracer technology is also utilized for studying tumor metabolism to track metabolite activity in the body and deep metabolic pathways.

FRONTIERS IN MOLECULAR BIOSCIENCES (2021)

Article Chemistry, Analytical

In Vitro Spatio-Temporal NMR Metabolomics of Living 3D Cell Models

Robert Knitsch et al.

Summary: Three-dimensional cell cultures are becoming increasingly important in biochemical research, requiring adaptations of established analytical techniques for more accurate representation of tissue features. This study presents an NMR-based approach to obtain dynamically radial metabolite profiles for cell spheroids, one of the most frequently used 3D models, using spatially selective NMR pulse sequences and a commercially available cryogenic NMR probe.

ANALYTICAL CHEMISTRY (2021)

Article Oncology

Bone sarcomas: ESMO-EURACAN-GENTURIS-ERN PaedCan Clinical Practice Guideline for diagnosis, treatment and follow-up

S. J. Strauss et al.

Summary: The paragraph lists the names of various researchers, possibly in the author list of a research paper.

ANNALS OF ONCOLOGY (2021)

Review Oncology

Metabolic landscapes in sarcomas

Richard Miallot et al.

Summary: Metabolic rewiring presents new therapeutic opportunities in cancer, particularly in soft tissue sarcomas with their heterogeneous tissue origin and genetic history. Genetic alterations skew activation pathways and orient metabolic rewiring in sarcomas. The diverse metabolic landscapes in tumors condition the tumor microenvironment, immune responses, and prognosis, providing potential targets for metabolite-targeting drugs in controlling sarcoma growth.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2021)

Article Multidisciplinary Sciences

Lineage-defined leiomyosarcoma subtypes emerge years before diagnosis and determine patient survival

Nathaniel D. Anderson et al.

Summary: Heterogeneity in leiomyosarcomas (LMS) makes treatment of the disease challenging. Here the authors analyze LMS heterogeneity and molecular LMS subtypes using genomics and transcriptomics, finding origins in distinct lineages and associations with survival, in addition to the early emergence of metastatic clones.

NATURE COMMUNICATIONS (2021)

Article Oncology

Overexpression of Replication-Dependent Histone Signifies a Subset of Dedifferentiated Liposarcoma with Increased Aggressiveness

Yongjin Yoo et al.

Summary: The overexpression of the histone gene cluster, caused by increased HMGA2, plays a critical role in predicting genome instability and cell proliferation in dedifferentiated liposarcoma. This genetic signature may serve as a biomarker for prognosis prediction in liposarcoma patients, indicating aggressiveness of the disease.

CANCERS (2021)

Article Oncology

Integrated Analysis of the Transcriptome Profile Reveals the Potential Roles Played by Long Noncoding RNAs in Immunotherapy for Sarcoma

Boran Pang et al.

Summary: The study identified long noncoding RNAs correlated with tumor cell immune evasion in sarcoma, with their upregulation associated with worse prognosis. These lncRNAs were found to be related to immune evasion and negative regulation of the immune response in sarcoma, and their high expression correlated with more suppressive immune cell infiltration and reduced sensitivity to immune checkpoint inhibitors in sarcoma and other human cancer types.

FRONTIERS IN ONCOLOGY (2021)

Article Oncology

Deep sequencing of myxoinflammatory fibroblastic sarcoma

Elsa Arbajian et al.

GENES CHROMOSOMES & CANCER (2020)

Article Multidisciplinary Sciences

Targeting glutamine metabolism slows soft tissue sarcoma growth

Pearl Lee et al.

NATURE COMMUNICATIONS (2020)

Article Immunology

IDO Targeting in Sarcoma: Biological and Clinical Implications

Imane Nafia et al.

FRONTIERS IN IMMUNOLOGY (2020)

Article Multidisciplinary Sciences

Towards applying NMR relaxometry as a diagnostic tool for bone and soft tissue sarcomas: a pilot study

Elzbieta Masiewicz et al.

SCIENTIFIC REPORTS (2020)

Article Medicine, Research & Experimental

Requirement for YAP1 signaling in myxoid liposarcoma

Marcel Trautmann et al.

EMBO MOLECULAR MEDICINE (2019)

Review Cell Biology

Identification of bioactive metabolites using activity metabolomics

Markus M. Rinschen et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2019)

Article Multidisciplinary Sciences

KRAS4A directly regulates hexokinase 1

Caroline R. Amendola et al.

NATURE (2019)

Article Medicine, Research & Experimental

Mutational landscape in genetically engineered, carcinogen-induced, and radiation-induced mouse sarcoma

Chang-Lung Lee et al.

JCI INSIGHT (2019)

Article Multidisciplinary Sciences

A Metabolomics Pilot Study on Desmoid Tumors and Novel Drug Candidates

Kelly A. Mercier et al.

SCIENTIFIC REPORTS (2018)

Article Biochemistry & Molecular Biology

Four Key Steps Control Glycolytic Flux in Mammalian Cells

Lukas Bahati Tanner et al.

CELL SYSTEMS (2018)

Review Oncology

Influence of the Tumor Microenvironment on Cancer Cells Metabolic Reprogramming

Victoire Gouirand et al.

FRONTIERS IN ONCOLOGY (2018)

Review Cell Biology

Interplay between YAP/TAZ and Metabolism

Ja Hyun Koo et al.

CELL METABOLISM (2018)

Review Medicine, General & Internal

Phosphatidylinositol 3-Kinase, Growth Disorders, and Cancer

Marcus D. Goncalves et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

Review Oncology

Soft Tissue Sarcoma Cancer Stem Cells: An Overview

Katia C. Genadry et al.

FRONTIERS IN ONCOLOGY (2018)

Article Biochemical Research Methods

Prognostic Metabolite Biomarkers for Soft Tissue Sarcomas Discovered by Mass Spectrometry Imaging

Sha Lou et al.

JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY (2017)

Editorial Material Oncology

Evolving biological understanding and treatment of sarcomas

Jean-Yves Blay et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2017)

Article Biochemistry & Molecular Biology

Comprehensive and Integrated Genomic Characterization of Adult Soft Tissue Sarcomas

Alexander J. Lazar et al.

Review Oncology

Application of metabolomics in sarcoma: From biomarkers to therapeutic targets

Li Min et al.

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (2017)

Article Oncology

Multinuclear NMR and MRI Reveal an Early Metabolic Response to mTOR Inhibition in Sarcoma

Valentina Di Gialleonardo et al.

CANCER RESEARCH (2017)

Article Oncology

The genomic landscape of epithelioid sarcoma cell lines and tumours

Farzad Jamshidi et al.

JOURNAL OF PATHOLOGY (2016)

Review Immunology

Metabolic adaptation of tissues to stress releases metabolites influencing innate immunity

Philippe Naquet et al.

CURRENT OPINION IN IMMUNOLOGY (2016)

Article Medicine, Research & Experimental

Tumor-associated fibroblasts promote the proliferation and decrease the doxorubicin sensitivity of liposarcoma cells

Kamran Harati et al.

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2016)

Review Oncology

From Krebs to clinic: glutamine metabolism to cancer therapy

Brian J. Altman et al.

NATURE REVIEWS CANCER (2016)

Article Biochemistry & Molecular Biology

Supporting Aspartate Biosynthesis Is an Essential Function of Respiration in Proliferating Cells

Lucas B. Sullivan et al.

Article Biochemistry & Molecular Biology

Aerobic glycolysis tunes YAP/TAZ transcriptional activity

Elena Enzo et al.

EMBO JOURNAL (2015)

Review Cell Biology

A new role for the PI3K/Akt signaling pathway in the epithelial-mesenchymal transition

Wenting Xu et al.

CELL ADHESION & MIGRATION (2015)

Review Biotechnology & Applied Microbiology

Analytical methods in untargeted metabolomics: state of the art in 2015

Arnald Alonso et al.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2015)

Article Multidisciplinary Sciences

Fructose-1,6-bisphosphatase opposes renal carcinoma progression

Bo Li et al.

NATURE (2014)

Review Oncology

Hypoxia and the extracellular matrix: drivers of tumour metastasis

Daniele M. Gilkes et al.

NATURE REVIEWS CANCER (2014)

Article Oncology

Targeting Oxidative Stress in Embryonal Rhabdomyosarcoma

Xiang Chen et al.

CANCER CELL (2013)

Review Immunology

Indoleamine 2,3 dioxygenase and metabolic control of immune responses

David H. Munn et al.

TRENDS IN IMMUNOLOGY (2013)

Article Oncology

Hypoxia-Dependent Modification of Collagen Networks Promotes Sarcoma Metastasis

T. S. Karin Eisinger-Mathason et al.

CANCER DISCOVERY (2013)

Review Oncology

Serine, glycine and one-carbon units: cancer metabolism in full circle

Jason W. Locasale

NATURE REVIEWS CANCER (2013)

Review Oncology

Consistency Test of the Cell Cycle: Roles for p53 and EGR1

Yaara Zwang et al.

CANCER RESEARCH (2012)

Review Oncology

Otto Warburg's contributions to current concepts of cancer metabolism

Willem H. Koppenol et al.

NATURE REVIEWS CANCER (2011)

Review Oncology

Utilization of positron emission tomography in the management of patients with sarcoma

Matthias R. Benz et al.

CURRENT OPINION IN ONCOLOGY (2009)

Review Pathology

Regulation of glucose metabolism by 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatases in cancer

Abdullah Yalcin et al.

EXPERIMENTAL AND MOLECULAR PATHOLOGY (2009)

Editorial Material Biochemistry & Molecular Biology

Metabolic phenotyping in health and disease

Elaine Holmes et al.

Review Biochemical Research Methods

Metabolomics: Current technologies and future trends

Katherine Hollywood et al.

PROTEOMICS (2006)

Article Radiology, Nuclear Medicine & Medical Imaging

Characterization of bone and soft-tissue tumors with in vivo 1H MR spectroscopy:: Initial results

CK Wang et al.

RADIOLOGY (2004)