期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 23, 期 21, 页码 -出版社
MDPI
DOI: 10.3390/ijms232113128
关键词
obesity; colorectal cancer; visceral adipose tissue; tumor microenvironment; adipocytes
资金
- Institute of Health Carlos III [AC20/00111, PI19/00002]
- CIBEROBN
- Govern Balear [PD-007-2021]
- ESF (European Social Fund)
- ERDF (European Regional Development Fund)
Obesity is a major risk factor for colorectal cancer, and visceral adipose tissue may play a key role in tumor development and progression.
Colorectal cancer (CRC) is a major health problem worldwide, with an estimated 1.9 million new cases and 915,880 deaths in 2020 alone. The etiology of CRC is complex and involves both genetic and lifestyle factors. Obesity is a major risk factor for CRC, and the mechanisms underlying this link are still unclear. However, the generalized inflammatory state of adipose tissue in obesity is thought to play a role in the association between CRC risk and development. Visceral adipose tissue (VAT) is a major source of proinflammatory cytokines and other factors that contribute to the characteristic systemic low-grade inflammation associated with obesity. VAT is also closely associated with the tumor microenvironment (TME), and recent evidence suggests that adipocytes within the TME undergo phenotypic changes that contribute to tumor progression. In this review, we aim to summarize the current evidence linking obesity and CRC, with a focus on the role of VAT in tumor etiology and progression.
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