期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 23, 期 21, 页码 -出版社
MDPI
DOI: 10.3390/ijms232112747
关键词
luminal breast cancer; subgroup; DNA methylation; immune microenvironment; scRNA-seq; pathology features
资金
- National Natural Science Foundation of China [U20A20376, 61972116, 62102120]
- Applied Technology Research and Development Project of Heilongjiang [GA20C018]
- Heilongjiang Postdoctoral Fund [LBH-Z20158]
- Heilongjiang Provincial Department of Education General Project [2016-KYYWF-0888]
- Qiqihar Medical College Doctoral Fund [QY2016B-24]
This study proposed a classification framework for luminal breast cancer based on DNA methylation profiles and transcriptomes. The identified immune subgroups showed significant differences in DNA methylation levels, immune microenvironment, and pathology features. In addition, a subgroup in luminal breast cancer was found to benefit from immunotherapy.
Luminal breast cancer (BC) accounts for a large proportion of patients in BC, with high heterogeneity. Determining the precise subtype and optimal selection of treatment options for luminal BC is a challenge. In this study, we proposed an MSBR framework that integrate DNA methylation profiles and transcriptomes to identify immune subgroups of luminal BC. MSBR was implemented both on a key module scoring algorithm and Boruta feature selection method by DNA methylation. Luminal A was divided into two subgroups and luminal B was divided into three subgroups using the MSBR. Furthermore, these subgroups were defined as different immune subgroups in luminal A and B respectively. The subgroups showed significant differences in DNA methylation levels, immune microenvironment (immune cell infiltration, immune checkpoint PD1/PD-L1 expression, immune cell cracking activity (CYT)) and pathology features (texture, eccentricity, intensity and tumor-infiltrating lymphocytes (TILs)). The results also showed that there is a subgroup in both luminal A and B that has the benefit from immunotherapy. This study proposed a classification of luminal BC from the perspective of epigenetics and immune characteristics, which provided individualized treatment decisions.
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