Proof-of-Principle Study Suggesting Potential Anti-Inflammatory Activity of Butyrate and Propionate in Periodontal Cells

Article Biochemistry & Molecular Biology

Heartwood of Dalbergia cochinchinensis: 4,7,2′-Trihydroxy-4′-methoxyisoflavanol and 6,4′-Dihydroxy-7-methoxyflavane Reduce Cytokine and Chemokine Expression In Vitro

Feng Shao et al.

Summary: Two flavonoids isolated from the heartwood of Dalbergia cochinchinensis were found to inhibit the inflammatory response of macrophages and fibroblastic cells.

MOLECULES (2022)

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Article Multidisciplinary Sciences

Butyrate promotes oral squamous cell carcinoma cells migration, invasion and epithelial-mesenchymal transition

Wenli Zang et al.

Summary: This study found that butyrate can promote the migration and invasion of oral squamous cell carcinoma (OSCC) cells by inducing epithelial-mesenchymal transition (EMT), indicating that butyrate may contribute to the metastasis of OSCC.

PEERJ (2022)

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Article Biochemistry & Molecular Biology

Butyrate Prevents Induction of CXCL10 and Non-Canonical IRF9 Expression by Activated Human Intestinal Epithelial Cells via HDAC Inhibition

Sandra G. P. J. Korsten et al.

Summary: Butyrate is the most effective in inhibiting CXCL10 release compared to other SCFAs, mainly through HDAC inhibition. Butyrate does not affect phosphorylated STAT1 and NF kappa B p65, but inhibits IRF9 and phosphorylated JAK2 protein expression in activated cells.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Biochemistry & Molecular Biology

Nrf2 Activation and NF-Kb & caspase/bax signaling inhibition by sodium butyrate alleviates LPS-induced cell injury in bovine mammary epithelial cells

Ilyas Ali et al.

Summary: This study investigates the protective effect of sodium butyrate (SB) on a lipopolysaccharide (LPS)-induced mastitis model in vitro. SB shows a concentration-dependent protective effect against LPS-induced death of bovine mammary epithelial cells (bMECs). It reduces oxidative stress, inflammation, and apoptosis by inhibiting NF-kB and caspase/Bax signaling pathways. The protective effect of SB is associated with the activation of the endogenous antioxidant system (Nrf2, Keap1, NQO-1, and HO-1). These findings suggest that SB could be a potential therapeutic agent for bovine mastitis.

MOLECULAR IMMUNOLOGY (2022)

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Article Dentistry, Oral Surgery & Medicine

A double-edged sword: Role of butyrate in the oral cavity and the gut

Xiaoyuan Guan et al.

Summary: Butyrate, a metabolite of anaerobic bacteria, plays crucial roles in the gut and oral cavity, influencing various diseases such as periodontitis. Despite its diverse functions in different organs, the impact of butyrate on different diseases provides valuable insights for further research.

MOLECULAR ORAL MICROBIOLOGY (2021)

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Article Biochemistry & Molecular Biology

Platelet-Rich Fibrin Decreases the Inflammatory Response of Mesenchymal Cells

Zahra Kargarpour et al.

Summary: The study reveals that PRF lysates exhibit potent anti-inflammatory activity in murine mesenchymal cells, reducing cytokine-induced expression of inflammatory mediators and inflammatory response.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Dentistry, Oral Surgery & Medicine

Long-term exposure to butyric acid induces excessive production of matrix metalloproteases in human gingival fibroblasts

Maki Nakagawa et al.

Summary: This study demonstrated that butyric acid reduces the viability of gingival fibroblasts and promotes overproduction of MMPs, disrupting the balance between MMPs and TIMPs. This imbalance could potentially lead to tissue destruction in periodontal disease.

ARCHIVES OF ORAL BIOLOGY (2021)

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Article Biochemistry & Molecular Biology

IL-33 Is Involved in the Anti-Inflammatory Effects of Butyrate and Propionate on TNFα-Activated Endothelial Cells

Meng Li et al.

Summary: The inhibitory effects of butyrate and propionate on TNF alpha-induced IL-8 production were mediated by the HDACs/IL-33/NF-kappa B pathway, while their effects on VCAM-1 expression might be associated with the HDACs/MAPK signaling pathway, independently of IL-33.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Medicine, Research & Experimental

Short-chain fatty acid butyrate: A novel shield against chronic gastric ulcer

Yan Zhou et al.

Summary: Butyrate treatment alleviated chronic gastric mucosa lesions in mice by regulating oxidative stress and inflammatory responses, promoting gastric mucosal repair factors, and the upregulation of specific receptor GPR109A played a key role in the therapeutic effects.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2021)

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Review Immunology

Oral Osteomicrobiology: The Role of Oral Microbiota in Alveolar Bone Homeostasis

Xingqun Cheng et al.

Summary: Osteomicrobiology is a new research field that aims to explore the role of microbiota in bone homeostasis, particularly focusing on the alveolar bone. Recent studies have shown the significant impact of oral microbiota on host defense systems and alveolar bone homeostasis. Advances in technology are rapidly advancing the mechanistic understanding of how oral microbiota mediate alveolar bone remodeling processes.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2021)

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Article Dentistry, Oral Surgery & Medicine

Gut Microbiota May Mediate the Influence of Periodontitis on Prediabetes

L. Li et al.

Summary: The study demonstrates a potential link between periodontitis and diabetes mediated by gut microbiota. Depletion of gut microbiota with antibiotics improved diabetes-related markers in periodontitis mice. This suggests a role of gut microbiota in influencing the impact of periodontitis on prediabetes.

JOURNAL OF DENTAL RESEARCH (2021)

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Article Nutrition & Dietetics

Dietary Derived Propionate Regulates Pathogenic Fibroblast Function and Ameliorates Experimental Arthritis and Inflammatory Tissue Priming

Jasna Friscic et al.

Summary: Short-chain fatty acids play important roles in regulating adaptive immune responses, and their influence on inflammation driven by innate immunity is not well studied. This study found that propionate treatment can reduce experimental arthritis and decrease inflammatory tissue damage by interfering with the production and migration of inflammatory mediators in synovial fibroblasts. The alleviating effect of propionate on arthritis may be attributed to the direct abrogation of local arthritogenic fibroblast function.

NUTRIENTS (2021)

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Article Dentistry, Oral Surgery & Medicine

Reactive oxygen species-dependent release of damage-associated molecular patterns from human gingival epithelial Ca9-22 cells during butyrate or propionate exposure

Yui Fujiwara et al.

Summary: Treatment with butyrate and propionate induces dose and time-dependent cell death in gingival epithelial Ca9-22 cells, accompanied by the release of DAMPs. The use of ROS scavengers, such as ascorbic acid and N-acetylcysteine, reduces cellular death and inhibits DAMP release induced by SCFAs. These findings suggest that SCFA-induced cell death and DAMP release are dependent on ROS.

JOURNAL OF ORAL SCIENCE (2021)

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Article Biochemistry & Molecular Biology

Butyrate Decreases ICAM-1 Expression in Human Oral Squamous Cell Carcinoma Cells

Gabriel Leonardo Magrin et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Review Biochemistry & Molecular Biology

Effects of Short-Chain Fatty Acids on Human Oral Epithelial Cells and the Potential Impact on Periodontal Disease: A Systematic Review of In Vitro Studies

Gabriel Leonardo Magrin et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Biophysics

Butyrate mitigates TNF-α-induced attachment of monocytes to endothelial cells

Yan Wang et al.

JOURNAL OF BIOENERGETICS AND BIOMEMBRANES (2020)

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Article Dentistry, Oral Surgery & Medicine

Proteomic analysis of Fusobacterium nucleatum growth in biofilm versus planktonic state

Arancha Llama-Palacios et al.

MOLECULAR ORAL MICROBIOLOGY (2020)

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Article Developmental Biology

The short-chain fatty acids butyrate and propionate protect against inflammation-induced activation of mediators involved in active labor: implications for preterm birth

Hope Eveline Carter Moylan et al.

MOLECULAR HUMAN REPRODUCTION (2020)

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Article Dentistry, Oral Surgery & Medicine

Berberine Ameliorates Periodontal Bone Loss by Regulating Gut Microbiota

X. Jia et al.

JOURNAL OF DENTAL RESEARCH (2019)

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Article Dentistry, Oral Surgery & Medicine

Butyrate rather than LPS subverts gingival epithelial homeostasis by downregulation of intercellular junctions and triggering pyroptosis

Juan Liu et al.

JOURNAL OF CLINICAL PERIODONTOLOGY (2019)

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Article Biochemistry & Molecular Biology

The gut microbiota modulator berberine ameliorates collagen-induced arthritis in rats by facilitating the generation of butyrate and adjusting the intestinal hypoxia and nitrate supply

Mengfan Yue et al.

FASEB JOURNAL (2019)

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Article Physiology

Short-chain fatty acids increase TNF alpha-induced inflammation in primary human lung mesenchymal cells through the activation of p38 MAPK

Sandra Rufting et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2019)

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Review Dentistry, Oral Surgery & Medicine

The periodontal pocket: pathogenesis, histopathology and consequences

Dieter D. Bosshardt

PERIODONTOLOGY 2000 (2018)

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Review Microbiology

The oral microbiota: dynamic communities and host interactions

Richard J. Lamont et al.

NATURE REVIEWS MICROBIOLOGY (2018)

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Review Immunology

Relationship between periodontal disease and butyric acid produced by periodontopathic bacteria

Michihiro Shirasugi et al.

INFLAMMATION AND REGENERATION (2018)

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Article Endocrinology & Metabolism

Short-Chain Fatty Acids Inhibit Oxidative Stress and Inflammation in Mesangial Cells Induced by High Glucose and Lipopolysaccharide

Wei Huang et al.

EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES (2017)

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Article Immunology

Sodium butyrate inhibits the NF-kappa B signaling pathway and histone deacetylation, and attenuates experimental colitis in an IL-10 independent manner

Changhyun Lee et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2017)

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Article Immunology

The Inflammation Induced by Lipopolysaccharide can be Mitigated by Short-chain Fatty Acid, Butyrate, through Upregulation of IL-10 in Septic Shock

F. Wang et al.

SCANDINAVIAN JOURNAL OF IMMUNOLOGY (2017)

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Article Biochemistry & Molecular Biology

Normal human gingival fibroblasts undergo cytostasis and apoptosis after long-term exposure to butyric acid

Michihiro Shirasugi et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2017)

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Article Dentistry, Oral Surgery & Medicine

Saliva initiates the formation of pro-inflammatory macrophages in vitro

Solmaz Pourgonabadi et al.

ARCHIVES OF ORAL BIOLOGY (2017)

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Article Agriculture, Dairy & Animal Science

Effects of Lactobacillus plantarum 2142 and sodium n-butyrate in lipopolysaccharide-triggered inflammation: Comparison of a porcine intestinal epithelial cell line and primary hepatocyte monocultures with a porcine enterohepatic co-culture system

O. Farkas et al.

JOURNAL OF ANIMAL SCIENCE (2014)

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Article Dentistry, Oral Surgery & Medicine

Impact of the Oral Commensal Flora on Alveolar Bone Homeostasis

K. Irie et al.

JOURNAL OF DENTAL RESEARCH (2014)

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Article Dentistry, Oral Surgery & Medicine

Effect of non-surgical periodontal treatment on short chain fatty acid levels in gingival crevicular fluid of patients with generalized aggressive periodontitis

R. Lu et al.

JOURNAL OF PERIODONTAL RESEARCH (2014)

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Article Peripheral Vascular Disease

Butyrate Attenuates Inflammation and Lipolysis Generated by the Interaction of Adipocytes and Macrophages

Hideo Ohira et al.

JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS (2013)

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Article Dentistry, Oral Surgery & Medicine

Butyrate induces reactive oxygen species production and affects cell cycle progression in human gingival fibroblasts

M. -C. Chang et al.

JOURNAL OF PERIODONTAL RESEARCH (2013)

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Article Dentistry, Oral Surgery & Medicine

Butyrate, a bacterial metabolite, induces apoptosis and autophagic cell death in gingival epithelial cells

H. Tsuda et al.

JOURNAL OF PERIODONTAL RESEARCH (2010)

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Article Dentistry, Oral Surgery & Medicine

Butyric acid induces apoptosis in inflamed fibroblasts

T. Kurita-Ochiai et al.

JOURNAL OF DENTAL RESEARCH (2008)

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Article Dentistry, Oral Surgery & Medicine

Inflammation and Bone Loss in Periodontal Disease

David L. Cochran

JOURNAL OF PERIODONTOLOGY (2008)

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Article Oncology

Retinoic acid and sodium butyrate as cell cycle regulators in the treatment of oral squamous carcinoma cells

Anxun Wang et al.

ONCOLOGY RESEARCH (2008)

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Article Immunology

Anti-inflammatory effects of short chain fatty acids in IFN-gamma-stimulated RAW 264.7 murine macrophage cells: Involvement of NF-kappa B and ERK signaling pathways

Jin-Sun Park et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2007)

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Article Dentistry, Oral Surgery & Medicine

Structure of periodontal tissues in health and disease

A Nanci et al.

PERIODONTOLOGY 2000 (2006)

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Article Gastroenterology & Hepatology

Preventive efficacy of butyrate enemas and oral administration of Clostridium butyricum M588 in dextran sodium sulfate-induced colitis in rats

T Okamoto et al.

JOURNAL OF GASTROENTEROLOGY (2000)

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Proof-of-Principle Study Suggesting Potential Anti-Inflammatory Activity of Butyrate and Propionate in Periodontal Cells

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