期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 23, 期 16, 页码 -出版社
MDPI
DOI: 10.3390/ijms23169349
关键词
AITL; follicular dendritic cell proliferation; CD30 expression; SARS-CoV-2 infection
In this study, we reported a case of AITL with coexisting SARS-CoV-2 infection and exuberant CD30-positive FDC proliferation. Genetic analysis identified mutations commonly involved in AITL but not in FDC sarcoma, supporting the reactive nature of the CD30-positive FDC expansion.
Follicular dendritic cell (FDC) proliferation in angioimmunoblastic T-cell lymphoma (AITL) is still not well defined, challenging the accurate differential diagnosis between the AITL with expanded follicular dendritic cell meshwork and the combined AITL and follicular dendritic cell sarcoma (FDCS). Herein, we reported the case of a 58-year-old male with coexisting SARS-CoV-2 infection and AITL with an exuberant CD30-positive FDC proliferation, in which genetic analysis identified mutations of genes commonly involved in AITL but not in FDC sarcoma (i.e., RHOA, TET2, DNMT3A, and IDH2), thus supporting the reactive nature of the CD30-positive FDC expansion.
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