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Act Early and at the Right Location: SARS-CoV-2 T Cell Kinetics and Tissue Localization

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MDPI
DOI: 10.3390/ijms231810679

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adaptive immunity against SARS-CoV-2; tissue-resident T cells

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  1. National Research Foundation [MOH-000019 (MOH-StaR17Nov-0001)]

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The emergence of new SARS-CoV-2 lineages that can escape antibodies has reduced the protection provided by Spike-specific antibodies. As a result, T cells have taken on a more central role in containing viral replication and spread.
The emergence of new SARS-CoV-2 lineages able to escape antibodies elicited by infection or vaccination based on the Spike protein of the Wuhan isolates has reduced the ability of Spike-specific antibodies to protect previously infected or vaccinated individuals from infection. Therefore, the role played by T cells in the containment of viral replication and spread after infection has taken a more central stage. In this brief review, we will discuss the role played by T cells in the protection from COVID-19, with a particular emphasis on the kinetics of the T cell response and its localization at the site of primary infection.

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