期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 23, 期 18, 页码 -出版社
MDPI
DOI: 10.3390/ijms231810887
关键词
MF59; CpG 1826; compound adjuvant; tumor vaccine; MUC1-MBP; dendritic cells
资金
- Changchun KangYue biotechnology Co., Ltd. [2018YX086]
This study evaluates the effects of MF59/CpG 1826 as a vaccine compound adjuvant on immune response, tumor suppression, and survival. The results demonstrate that MF59 enhances tumor growth inhibition and Th1-prone cellular immune response induced by CpG 1826/M-M vaccine. Furthermore, MF59 reduces individual differences in tumor growth and prolongs prophylactic and therapeutic mouse survival. The mechanism may involve the promotion of dendritic cell maturation by MF59.
Our previous study found that CpG oligodeoxynucleotides 1826 (CpG 1826), combined with mucin 1 (MUC1)-maltose-binding protein (MBP) (M-M), had certain antitumor activity. However, this combination is less than ideal for tumor suppression (tumors vary in size and vary widely among individuals), with a drawback being that CpG 1826 is unstable. To solve these problems, here, we evaluate MF59/CpG 1826 as a compound adjuvant with M-M vaccine on immune response, tumor suppression and survival. The results showed that MF59 could promote the CpG 1826/M-M vaccine-induced tumor growth inhibition and a Th1-prone cellular immune response, as well as reduce the individual differences of tumor growth and prolonged prophylactic and therapeutic mouse survival. Further research showed that MF59 promotes the maturation of DCs stimulated by CpG1826/M-M, resulting in Th1 polarization. The possible mechanism is speculated to be that MF59 could significantly prolong the retention time of CpG 1826, or the combination of CpG 1826 and M-M, as well as downregulate IL-6/STAT3 involved in MF59 combined CpG 1826-induced dendritic cell maturation. This study clarifies the utility of MF59/CpG 1826 as a vaccine compound adjuvant, laying the theoretical basis for the development of a novel M-M vaccine.
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