4.7 Article

Discovery of a Dual SENP1 and SENP2 Inhibitor

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Chemistry, Medicinal

Small-molecule inhibitors targeting small ubiquitin-like modifier pathway for the treatment of cancers and other diseases

Dexiang Hua et al.

Summary: SUMOylation is a key post-translational modification process that is essential for normal cellular functions. Dysregulation of SUMOylation is associated with various diseases, and small-molecular inhibitors targeting this pathway have been discovered.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2022)

Review Biochemistry & Molecular Biology

Cancer-Associated Dysregulation of Sumo Regulators: Proteases and Ligases

Nieves Lara-Urena et al.

Summary: SUMOylation is an important post-translational modification that regulates diverse physiological processes. Dysregulation of the SUMO pathway, involving proteases and ligases, is associated with cancer initiation and progression.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Review Chemistry, Medicinal

Recent research and development of inhibitors targeting sentrin-specific protease 1 for the treatment of cancers

Junxia Wei et al.

Summary: This review summarizes the role of SENP1 in tumorigenesis and development, focusing on the design and discovery of small molecule inhibitors. It provides ideas for the future development and research of SENP1 inhibitors.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2022)

Review Chemistry, Multidisciplinary

Acyclic Twisted Amides

Guangrong Meng et al.

Summary: This contribution provides a comprehensive overview of acyclic twisted amides since 1993, focusing on their key structural properties and applications in various fields of chemistry.

CHEMICAL REVIEWS (2021)

Review Oncology

Therapeutic Potential of Targeting the SUMO Pathway in Cancer

Antti Kukkula et al.

Summary: The SUMO pathway plays a crucial role in regulating cancer cell properties, and inhibition of this pathway shows promise as a potential therapeutic option for cancer treatment.

CANCERS (2021)

Review Oncology

Targeting SUMO Signaling to Wrestle Cancer

Jessie S. Kroonen et al.

Summary: The SUMO signaling cascade is crucial for gene expression, genome integrity, and cell cycle progression. Small molecule inhibitors targeting SUMOylation pathway have potential as a new therapeutic strategy for cancer, leading to reduced cancer cell proliferation and increased antitumor immune response. Ongoing research is focusing on identifying tumor types that can be effectively treated with SUMOylation inhibitors.

TRENDS IN CANCER (2021)

Review Oncology

SUMO and the robustness of cancer

Jacob-Sebastian Seeler et al.

NATURE REVIEWS CANCER (2017)

Article Biochemistry & Molecular Biology

SENP1 regulates cell migration and invasion in neuroblastoma

Yan Xiang-ming et al.

BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY (2016)

Article Chemistry, Medicinal

Identification of SENP1 inhibitors through in silico screening and rational drug design

Yaxue Zhao et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2016)

Article Biochemistry & Molecular Biology

SENP1 inhibition induces apoptosis and growth arrest of multiple myeloma cells through modulation of NF-κB signaling

Jun Xu et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2015)

Article Medicine, Research & Experimental

Disturbed flow-activated p90RSK kinase accelerates atherosclerosis by inhibiting SENP2 function

Kyung-Sun Heo et al.

JOURNAL OF CLINICAL INVESTIGATION (2015)

Article Biotechnology & Applied Microbiology

The role of ligand efficiency metrics in drug discovery

Andrew L. Hopkins et al.

NATURE REVIEWS DRUG DISCOVERY (2014)

Article Biochemistry & Molecular Biology

Identification and Characterization of a New Chemotype of Noncovalent SENP Inhibitors

Ikenna G. Madu et al.

ACS CHEMICAL BIOLOGY (2013)

Review Biochemistry & Molecular Biology

Regulation of DNA Damage Responses by Ubiquitin and SUMO

Stephen P. Jackson et al.

MOLECULAR CELL (2013)

Article Oncology

Prognostic impact of SUMO-specific protease 1 (SENP1) in prostate cancer patients undergoing radical prostatectomy

Tao Li et al.

UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS (2013)

Article Biochemistry & Molecular Biology

Glycine Fluoromethylketones as SENP-Specific Activity Based Probes

Cristian Dobrota et al.

CHEMBIOCHEM (2012)

Article Chemistry, Medicinal

Design, synthesis, and biological evaluation of benzodiazepine-based SUMO-specific protease 1 inhibitors

Zhitao Qiao et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2011)

Article Biochemistry & Molecular Biology

Development of Small Molecule Inhibitors and Probes of Human SUMO Deconjugating Proteases

Victoria E. Albrow et al.

CHEMISTRY & BIOLOGY (2011)

Article Chemistry, Multidisciplinary

Open Babel: An open chemical toolbox

Noel M. O'Boyle et al.

JOURNAL OF CHEMINFORMATICS (2011)

Article Chemistry, Applied

A General and Practical Access to Chiral Quinoxalinones with Low Copper-Catalyst Loading

Shinji Tanimori et al.

ADVANCED SYNTHESIS & CATALYSIS (2010)

Article Biochemistry & Molecular Biology

Induction of SENP1 in Endothelial Cells Contributes to Hypoxia-driven VEGF Expression and Angiogenesis

Ying Xu et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2010)

Article Biochemistry & Molecular Biology

SENP1 Induces Prostatic Intraepithelial Neoplasia through Multiple Mechanisms

Tasneem Bawa-Khalfe et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2010)

Article Biochemistry & Molecular Biology

Control of Adipogenesis by the SUMO-Specific Protease SENP2

Sung Soo Chung et al.

MOLECULAR AND CELLULAR BIOLOGY (2010)

Review Biochemistry & Molecular Biology

SUMOylation and De-SUMOylation: Wrestling with Life's Processes

Edward T. H. Yeh

JOURNAL OF BIOLOGICAL CHEMISTRY (2009)

Article Chemistry, Multidisciplinary

AutoDock4 and AutoDockTools4: Automated Docking with Selective Receptor Flexibility

Garrett M. Morris et al.

JOURNAL OF COMPUTATIONAL CHEMISTRY (2009)

Article Cell Biology

Emerging roles of the SUMO pathway in mitosis

Mary Dasso

Cell Division (2008)

Article Biochemistry & Molecular Biology

Small ubiquitin-related modifier (SUMO)-specific proteases -: Profiling the specificities and activities of human SENPs

Jowita Mikolajczyk et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2007)

Article Biochemistry & Molecular Biology

Small-molecule inhibitors and probes for ubiquitin- and ubiquitin-like-specific proteases

A Borodovsky et al.

CHEMBIOCHEM (2005)

Review Biochemistry & Molecular Biology

SUMO:: a regulator of gene expression and genome integrity

S Müller et al.

ONCOGENE (2004)