期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 23, 期 20, 页码 -出版社
MDPI
DOI: 10.3390/ijms232012106
关键词
polyphenol; lncRNA 495810; PKM2; aerobic glycolysis; colorectal cancer
资金
- National Natural Science Foundation of China [32072220, 82072718]
- Project of the Central Government Guiding Local Science and Technology [YDZX20201400001436]
Polyphenol-rich foods, such as foxtail millet, have potential beneficial effects in the prevention and treatment of cancer. Ferulic acid and p-coumaric acid, found in foxtail millet bran, exhibit significant anticancer properties and have a synergistic effect. These compounds inhibit aerobic glycolysis of colorectal cancer cells by targeting lncRNA 495810 and the rate-limiting enzyme PKM2.
Polyphenol-rich foods are gaining popularity due to their potential beneficial effects in the prevention and treatment of cancer. Foxtail millet is one of the important functional foods, riches in a variety of biologically active substance. Our previous study showed that ferulic acid (FA) and p-coumaric acid (p-CA) are the main anticancer components of foxtail millet bran, and the two have a significant synergistic effect. In the present study, the clinical application potential of FA and p-CA (FA + p-CA) were evaluated in vivo and in vitro. The FA and p-CA target gene enrichment analysis discovered that FA + p-CA were associated with aerobic glycolysis. It was further shown that FA + p-CA remodel aerobic glycolysis by inhibiting the glycolysis-associated lncRNA 495810 and the glycolytic rate-limiting enzyme M2 type pyruvate kinase (PKM2). Moreover, PKM2 expression was positively correlated with lncRNA 495810. More interestingly, the exogenous expression of lncRNA 495810 eliminated the inhibitory effects of FA + p-CA on aerobic glycolysis. Collectively, FA + p-CA obstruct the aerobic glycolysis of colorectal cancer cells via the lncRNA 495810/PKM2 axis, which provides a nutrition intervention and treatment candidate for colorectal cancer.
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