4.7 Article

Carboxymethylated hyperbranched polysaccharide: Synthesis, solution properties, and fabrication of hydrogel

期刊

CARBOHYDRATE POLYMERS
卷 128, 期 -, 页码 179-187

出版社

ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2015.04.012

关键词

Carboxymethylated hyperbranched; polysaccharide; Silk fibroin; Chain conformation; Hydrogel

资金

  1. National Natural Science Foundation of China [21344006]
  2. China Scholarship Council [2011842374]

向作者/读者索取更多资源

The periphery of hyperbranched polysaccharides has many end groups that can be functioned and used as sites to interact with their surroundings. A water-insoluble hyperbranched (beta-D-glucan, coded as TM3a, extracted from sclerotia of an edible fungus (Pleurotus tuber-regium), was fractionated and modified chemically to obtain carboxymethylated derivatives (CTM3a). The solution properties of the carboxymethylated polysaccharides were studied systematically in phosphate buffer saline at 37 degrees C. The results indicated that the carboxymethylated glucans still kept hyperbranched structure after carboxymethylation, and existed as a swollen sphere-like chain conformation. The introduction of carboxymethylated groups permitted the formation of hydrogels through crosslinking CTM3a and silk fibroin with carbodiimide chemistry. The resultant hydrogels with porous and interconnected structure displayed good mechanical and swelling properties. This work provides some valuable and fundamental information of the natural hyperbranched polysaccharide from mushroom for further application in biomedical devices and tissue engineering. (C) 2015 Elsevier Ltd. All rights reserved.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据