期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷 216, 期 -, 页码 916-926出版社
ELSEVIER
DOI: 10.1016/j.ijbiomac.2022.07.100
关键词
Oyster polysaccharide; Anti-obesity; Lipid metabolism; Short-chain fatty acids; Gut microbiota
资金
- National Key Research and Devel- opment Program of China [2018YFD0901000]
- Shandong Provincial Key Research and Development Program [2018GHY115012]
The study found that oyster polysaccharide (OPS) has anti-obesity effects, as it can reduce weight gain, improve dyslipidemia, and metabolic endotoxemia in obese mice. OPS also regulates lipid metabolism and improves gut microbiota dysbiosis caused by a high-fat diet.
Oyster is nutritious shellfish, wildly consumed throughout the world. Its polysaccharide (OPS) has various bioactivity. In the present study, the anti-obesity effect of OPS was evaluated in obese mice induced by a high-fat diet (HFD). The results showed that OPS significantly alleviated weight gain, dyslipidemia, and metabolic endotoxemia of obese mice, and accelerated the production of short-chain fatty acids. OPS also regulated lipid metabolism of adipose and liver by activating the expression of p-AMPK alpha to further down-regulate the expression of SREBP-1c, PPAR gamma, and p-ACC-1. 16S rRNA results indicated that OPS corrected HFD-induced gut microbiota dysbiosis by enriching beneficial bacteria (Bifidobacterium, Lactobacillus, Dobosiella, and Faecalibaculum) and decreasing harmful bacteria (Erysipelatoclostridium, Helicobacter, and Mucispirillum). In summary, these results revealed that OPS could serve as a potential prebiotic to improve obesity.
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