Green synthesis of guar gum/Ag nanoparticles and their role in peel-off gel for enhanced antibacterial efficiency and optimization using RSM

Polysaccharide-based guar gum (GG) biopolymer is used via a hydrothermal process to synthesize silver nanoparticles. The GG biopolymer act as a reducing and stabilizing agent. Moreover, GG was used for preparing peel -off masks to provide the desired consistency of formulation and synthesis of nanoparticles as an antibacterial agent. This work presents the novel GG/Ag nanoparticles peel-off gel and evaluates the antibacterial efficiency. The synthesized Ag-nanoparticles analyzed by UV-spectroscopy reflect a prominent peak at 413 nm. The size and distribution of nanoparticles were examined by TEM images obtained from the 6 to 18 nm range. We demonstrate the efficiency of peel-off facial gel as an antibacterial and preservative-free cosmetic product at different temperature ranges. The RSM study was used for parameter optimization of peel-off gel for extrudability, spreadability, and drying time by employing a CCD. The results show that the optimized GG, PVA, and ethanol concentration were 3.47, 8.30, and 5.80 w/w%, respectively, with 0.02 w/w% Ag nanoparticles. The peel-off gel antibacterial activity against Escherichia coli (11 +/- 0.1 mm), Staphylococcus aureus (10 & PLUSMN; 0.3 mm), and Propio-nibacterium acnes (11 +/- 0.3 mm). The peel-off gel was prepared from natural ingredients; due to this, it is nontoxic for human skin.

Automated summary

Polysaccharide-based guar gum (GG) biopolymer is used to synthesize silver nanoparticles via a hydrothermal process, with GG acting as a reducing and stabilizing agent. In addition, GG is used to prepare peel-off masks as antibacterial agents. The synthesized GG/Ag nanoparticles peel-off gel shows good antibacterial efficiency against various bacteria.