期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷 221, 期 -, 页码 371-380出版社
ELSEVIER
DOI: 10.1016/j.ijbiomac.2022.09.003
关键词
Nano tantalum; Polylactic acid; Beta-tricalcium phosphate; Bone regeneration; 3D-printing
资金
- Research Program of PLA [20WQ030, 2021NZC026]
- Science and Technology Plan of Jiangxi Provincial Health Commission [20204428]
- National Natural Science Foundation of China [81972080]
- Science and Technology Planning Project of Guangdong Province [2017B030314139]
Research on 3D printed scaffolds doped with nano tantalum shows potential in improving bone defect treatment by enhancing bioactivity and osteogenesis.
Bone defects caused by tumors section, traffic accidents, and surgery remain a challenge in clinical. The draw-backs of traditional autografts and allografts limit their clinical application. 3D printed porous scaffolds have monumental potential to repair bone defects but still cannot effectively promote bone formation. Nano tantalum (Ta) has been reported with effective osteogenesis capability. Herein, we fabricated 3D printed PLA/beta-TCP scaffold by using the fused deposition modeling (FDM) technique. Ta was doped on the surface of scaffolds utilizing the surface adhesion ability of polydopamine to improve its properties. The constructed PLA/beta-TCP/ PDA/Ta had good physical properties. In vitro studies demonstrated that the PLA/beta-TCP/PDA/Ta scaffolds considerably promote cell proliferation and migration, and it additionally has osteogenic properties. Therefore, Ta doped 3D printed PLA/beta-TCP/PDA/Ta scaffold could incontestably improve surface bioactivity and lead to better osteogenesis, which may provide a unique strategy to develop bioactive bespoke implants in orthopedic applications.
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