期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷 221, 期 -, 页码 1259-1270出版社
ELSEVIER
DOI: 10.1016/j.ijbiomac.2022.09.013
关键词
Cannabidiol; Hydrogel; Spinal cord injury; Mitochondrial biogenesis; Apoptosis
资金
- National Natural Science Foundation of China [41671302, 41977127]
- Natural Science Foundation of Guangdong Province of China [2022A1515012466]
An injectable in situ gelling hydrogel loaded with cannabidiol has been developed for local delivery, showing promise as a biomaterial for tissue engineering and spinal cord injury treatment.
The treatment of traumatic spinal cord injury (SCI) remains challenging as the neuron regeneration is impaired by irregular cavity and apoptosis. An injectable in situ gelling hydrogel is therefore developed for the local delivery of cannabidiol (CBD) through a novel method based on polyelectrolyte (PEC) interaction of sodium carboxymethylcellulose (CMC) and chitosan (CS). It can be injected into the spinal cord cavity with a 26-gauge syringe before gelation, and gelled after 110 +/- 10 s. Of note, the in-situ forming hydrogel has mechanical properties similar to spinal cord. Moreover, the CBD-loaded hydrogels sustain delivery of CBD for up to 72 h, resulting in reducing apoptosis in SCI by enhancing mitochondrial biogenesis. Importantly, the CBD-loaded hydrogels raise neurogenesis more than pure hydrogels both in vivo and in vitro, further achieving significant recovery of motor and urinary function in SCI rats. Thus, it suggested that CMC/CS/CBD hydrogels could be used as promising biomaterials for tissue engineering and SCI.
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