期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷 221, 期 -, 页码 806-820出版社
ELSEVIER
DOI: 10.1016/j.ijbiomac.2022.09.050
关键词
Oral administration; Ulcerative colitis; Curcumin; Double-membrane microgels
资金
- National Natural Science Foundation of China [81401510]
- Hubei Provincial Natural Science Foundation of China [2017CFB414]
- TCM research project of Hubei health and Family Planning Commission [ZY2019M031]
- Fundamental Research Funds for the Central Universities, South-Central MinZu University [CZZ21010]
In this study, a new oral drug delivery system was developed using multi-bioresponsive microgels loaded with anti-inflammatory drug curcumin. The microgels exhibited good bio-responses and sustained-release properties, and specifically accumulated in the colon tissue to alleviate the symptoms of ulcerative colitis.
Anti-inflammatory drugs for ulcerative colitis (UC) treatment should specifically penetrate and accumulate in the colon tissue. Herein, a multi-bioresponsive anti-inflammatory drug (curcumin, CUR)-loaded heterogeneous double-membrane microgels (CUR@microgels) for oral administration was fabricated in this study, in which the inner core was derived from polyvinyl alcohol (PVA) and guar gum (GG) and the outer gel was decoration with alginate and chitosan by polyelectrolyte interactions. The structure and morphology of microgels were charac-terized. In vitro, the formulation exhibited good bio-responses at different pH conditions and sustained-release properties in simulated colon fluid with a drug-release rate of 84.6 % over 34 h. With the assistance of the outlayer gels, the microgels effectively delayed the premature drug release of CUR in the upper gastrointestinal tract. In vivo studies revealed that CUR@microgels specifically accumulated in the colon tissue for 24 h, which suggest that the interlayer gels were apt to reach colon lesion. As expected, the oral administration of microgels remarkably alleviated the symptoms of UC and protected the colon tissue in DSS-induced UC mice. The above results indicated that these facilely fabricated microgels which exhibited excellent biocompatibility and multi-bioresponsive drug release, had an apparent effect on the treatment of UC, which represents a promising drug delivery strategy for CUR in a clinical application.
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