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Selection of Self-Reactive T Cells in the Thymus
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T cell receptor signal strength in Treg and iNKT cell development demonstrated by a novel fluorescent reporter mouse
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A Major Role for Bim in Regulatory T Cell Homeostasis
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Bcl-2 Allows Effector and Memory CD8+ T Cells To Tolerate Higher Expression of Bim
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LIGM-DB/IMGT: An Integrated Database of Ig and TcR, Part of the Immunogenetics Databasea
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Wei Jiang et al.
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IL-15 triggers an antiapoptotic pathway in human intraepithelial lymphocytes that is a potential new target in celiac disease-associated inflammation and lymphomagenesis
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STAT5 Is Critical To Maintain Effector CD8+ T Cell Responses
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A Novel TCR Transgenic Model Reveals That Negative Selection Involves an Immediate, Bim-Dependent Pathway and a Delayed, Bim-Independent Pathway
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Aire-Deficient C57BL/6 Mice Mimicking the Common Human 13-Base Pair Deletion Mutation Present with Only a Mild Autoimmune Phenotype
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Bim-Mediated Apoptosis Is Not Necessary for Thymic Negative Selection to Ubiquitous Self-Antigens
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Trans-Presentation of IL-15 by Intestinal Epithelial Cells Drives Development of CD8αα IELs
Lisa J. Ma et al.
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Clonal deletion of thymocytes can occur in the cortex with no involvement of the medulla
Tom M. McCaughtry et al.
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IL-15 does not affect IEL development in the thymus but regulates homeostasis of putative precursors and mature CD8αα+ IELs in the intestine
Yein-Gei Lai et al.
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The alliance of sphingosine-1-phosphate and its receptors in immunity
Juan Rivera et al.
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Bim and Bcl-2 mutually affect the expression of the other in T cells
Trine N. Jorgensen et al.
JOURNAL OF IMMUNOLOGY (2007)
The extrathymic T-cell differentiation in the murine gut
Benedita Rocha
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Thymic differentiation of TCRαβ+ CD8αα+ IELs
Florence Lambolez et al.
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Loss of Bim results in abnormal accumulation of mature CD4(-)CD8(-)CD44(-)CD25(-) thymocytes
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IL-15 protects intestinal epithelial cells
Florian Obermeier et al.
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Identification of pre- and postselection TCRαβ+ intraepithelial lymphocyte precursors in the thymus
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CELL (2005)
Combined loss of proapoptotic genes Bak or Bax with Bim synergizes to cause defects in hematopoiesis and in thymocyte apoptosis
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Selective expression of the Cre recombinase in late-stage thymocytes using the distal promoter of the Lck gene
DJ Zhang et al.
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Mesenteric B cells centrally inhibit CD4+ T cell colitis through interaction with regulatory T cell subsets
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Distinct cell types control lymphoid subset development by means of IL-15 and IL-15 receptor α expression
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Negative selection imparts peptide specificity to the mature T cell repertoire
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Extrathymic T cell lymphopoiesis: Ontogeny and contribution to gut intraepithelial lymphocytes in athymic and euthymic mice
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Projection of an immunological self shadow within the thymus by the aire protein
MS Anderson et al.
SCIENCE (2002)
A unique subset of self-specific intraintestinal T cells maintains gut integrity
P Poussier et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2002)
BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes
P Bouillet et al.
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Interactions between double positive thymocytes and high affinity ligands presented by cortical epithelial cells generate double negative thymocytes with T cell regulatory activity
RF Wang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
Precursors of functional MHC class I- or class II-restricted CD8 alpha alpha(+) T cells are positively selected in the thymus by agonist self-peptides
AJ Leishman et al.
IMMUNITY (2002)
Progression of T cell lineage restriction in the earliest subpopulation of murine adult thymus visualized by the expression of lck proximal promoter activity
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Reversible defects in natural killer and memory CD8 T cell lineages in interleukin 15-deficient mice
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JOURNAL OF EXPERIMENTAL MEDICINE (2000)