期刊
JOURNAL OF IMMUNOLOGY
卷 196, 期 8, 页码 3385-3397出版社
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.1502034
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资金
- Intramural Research Program of the National Institute on Aging, National Institutes of Health
B cell dysregulation in aging is thought to mostly occur in conventional B2 cells without affecting innate B1 cells. Elderly humans and mice also accumulate 4-1BBL(+) MHC class-I-Hi CD86(Hi) B cells of unknown origin. In this article, we report that these cells, termed 4BL cells, are activated murine and possibly human B1a cells. The activation is mediated by aging human monocytes and murine peritoneal macrophages. They induce expression and activation of 4-1BBL and IFN-gamma R1 on B1a cells to subsequently upregulate membrane TNF-alpha and CD86. As a result, activated B1a/4BL cells induce expression of granzyme B in CD8(+) T cells by targeting TNFR2 via membrane TNF-alpha and providing costimulation with CD86. Thus, for the first time, to our knowledge, these results indicate that aging affects the function of B1a cells. Upon aging, these cells lose their tumor-supporting activity and become inducers of potentially antitumor and autoimmune CD8(+) T cells.
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