Interleukin-35 ameliorates cardiovascular disease by suppressing inflammatory responses and regulating immune homeostasis

The immune response is of great significance in the initiation and progression of a diversity of cardiovascular diseases involving pro-and anti-inflammatory cytokines. Interleukin-35 (IL-35), a cytokine of the interleukin-12 family, is a novel anti-inflammation and immunosuppressive cytokine, maintaining inflammatory suppression and regulating immune homeostasis. The role of IL-35 in cardiovascular diseases (CVDs) has aroused enthusiastic attention, a diversity of experimental or clinical evidence has indicated that IL-35 potentially has a pivot role in protecting against cardiovascular diseases, especially atherosclerosis and myocarditis. In this review, we initiate an overview of the relationship between Interleukin-35 and cardiovascular diseases, including atherosclerosis, acute coronary syndrome, pulmonary hypertension, abdominal aortic aneurysm, heart failure, myocardial ischemia-reperfusion, aortic dissection and myocarditis. Although the specific molecular mechanisms entailing the protective effects of IL-35 remain an unsolved issue, targeted therapies with IL-35 might provide a promising and effective solution to prevent and cure cardiovascular diseases.

Automated summary

The immune response plays a crucial role in the initiation and progression of cardiovascular diseases. IL-35, a novel anti-inflammatory and immunosuppressive cytokine, has been found to have a significant impact on the regulation of inflammation and immune homeostasis. It is closely associated with cardiovascular diseases, particularly in protecting against atherosclerosis and myocarditis. Although the specific molecular mechanisms of IL-35's protective effects are still unclear, targeted therapies with IL-35 have the potential to provide a promising and effective solution for preventing and treating cardiovascular diseases.