Amomum longiligulare polysaccharide 1-PLGA nanoparticle promotes the immune activities of T lymphocytes and dendritic cells

Article Pharmacology & Pharmacy

Lentinan PLGA-stabilized pickering emulsion for the enhanced vaccination

Lina Jiao et al.

Summary: The study successfully constructed an adjuvant delivery system LNTPP/OVA with good stability and high loading capacity, which effectively enhanced the uptake of OVA antigen and induced cellular and humoral immune responses in vivo.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2022)

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Article Biochemistry & Molecular Biology

Glucose-rich polysaccharide from dried 'Shixia' longan activates macrophages through Ca2+ and CR3-mediated MAPKs and PI3K-AKT pathways

Haibo Lan et al.

Summary: The water-soluble glucose-rich polysaccharide LPsx from dried 'Shixia' longan pulp has been isolated and studied for its structure and immuno-regulatory mechanism. LPsx showed immunomodulatory activity by enhancing macrophage phagocytosis and promoting the production of various inflammatory factors, while also inhibiting the inflammatory response induced by lipopolysaccharide. The mechanism of immuno-regulation was found to involve Ca2+ and CR3-mediated MAPKs and PI3K-AKT signaling pathways in macrophage activation.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

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Article Immunology

Preparation of Amomum longiligulare polysaccharides 1-PLGA nanoparticle and its immune enhancement ability on RAW264.7 cells

Ruigang Zhou et al.

Summary: The study successfully prepared Amomum longiligulare polysaccharides 1 (ALP1) into nanoparticles (ALPP) with optimal preparation conditions of volume ratios and F68 concentration. ALPP demonstrated controlled and sustained release, as well as a better activation effect on macrophages compared to ALP1.

INTERNATIONAL IMMUNOPHARMACOLOGY (2021)

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Article Biochemistry & Molecular Biology

Cationic polymer-modified Alhagi honey polysaccharide PLGA nanoparticles as an adjuvant to induce strong and long-lasting immune responses

Adelijiang Wusiman et al.

Summary: In this study, cationic polymer-coated Alhagi honey polysaccharide-encapsulated PLGA nanoparticles were developed as positively charged antigen carriers. Among these carriers, the H5N1-loaded PEI-AHPP formulation showed the highest immune response induction. The findings suggest that PEI-AHPP has the potential to be an effective adjuvant for strong and long-lasting mixed immune responses.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

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Article Biochemistry & Molecular Biology

Characterizations of glucose-rich polysaccharides from Amomum longiligulare TL Wu fruits and their effects on immunogenicities of infectious bursal disease virus VP2 protein

Yongjian Zhu et al.

Summary: The study focused on the characterization of Amomum longiligulare T.L. Wu fruits polysaccharide (ALP) and its immune enhancement effects. Two homogeneous polysaccharides (ALP1 and ALP2) were isolated, both mainly composed of glucose. ALP1 and ALP2 showed immune enhancement effects on chickens, with ALP1 demonstrating higher immune enhancement ability, potentially serving as an adjuvant for IBDV VP2 protein.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

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Article Pharmacology & Pharmacy

PLGA-based biodegradable microspheres in drug delivery: recent advances in research and application

Yue Su et al.

Summary: Biodegradable microspheres are widely used in medicine for drug delivery with advantages of low dose and low side effects. PLGA is one of the most widely used biodegradable materials with good biocompatibility. PLGA microspheres have been extensively studied and applied in drug delivery.

DRUG DELIVERY (2021)

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Article Biochemistry & Molecular Biology