期刊
JOURNAL OF IMMUNOLOGY
卷 196, 期 5, 页码 2272-2282出版社
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.1502006
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资金
- Research Fund for Chinese Universities Scientific Fund [2015SY003]
- Beijing Natural Science Foundation, China [6151001]
- Doctoral Program of Higher Education of China [20130008110028]
- State Key Laboratory of Agrobiotechnology Fund [2014SKLAB1-3, 2015SKLAB1-2]
Porcine reproductive and respiratory syndrome virus (PRRSV) is an economically important pathogen and has evolved several mechanisms to evade IFN-I responses. We report that a host microRNA, miR-30c, was upregulated by PRRSV via activating NF-kappa B and facilitated its ability to infect subject animals. Subsequently, we demonstrated that miR-30c was a potent negative regulator of IFN-I signaling by targeting JAK1, resulting in the enhancement of PRRSV infection. In addition, we found that JAK1 expression was significantly decreased by PRRSV and recovered when miR-30c inhibitor was overexpressed. Importantly, miR-30c was also upregulated by PRRSV infection in vivo, and miR-30c expression corresponded well with viral loads in lungs and porcine alveolar macrophages of PRRSV-infected pigs. Our findings identify a new strategy taken by PRRSV to escape IFN-I-mediated antiviral immune responses by engaging miR-30c and, thus, improve our understanding of its pathogenesis.
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