期刊
JOURNAL OF IMMUNOLOGY
卷 197, 期 11, 页码 4210-4218出版社
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.1601426
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- National Institutes of Health [R01 AI073755, R01 AI104972, R01 AI114816, T32 AI007172]
Chikungunya virus (CHIKV) is a re-emerging alphavirus that causes debilitating acute and chronic arthritis. Infection by CHIKV induces a robust immune response that is characterized by production of type I IFNs, recruitment of innate and adaptive immune cells, and development of neutralizing Abs. Despite this response, chronic arthritis can develop in some individuals, which may be due to a failure to eliminate viral RNA and Ag and/or persistent immune responses that cause chronic joint inflammation. In this review, based primarily on advances from recent studies in mice, we discuss the innate and adaptive immune factors that control CHIKV dissemination and clearance or contribute to pathogenesis.
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