期刊
JOURNAL OF IMMUNOLOGY
卷 197, 期 11, 页码 4283-4291出版社
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.1601424
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资金
- Royal Society/Wellcome Trust Sir Henry Dale Fellowship [WT105677]
- Wellington Hospital, London fellowship
- Wellcome Trust investigator award
- Medical Research Council [MR/M020126/1] Funding Source: researchfish
- National Institute for Health Research [10/4001/11] Funding Source: researchfish
- Wellcome Trust [101849/Z/13/Z] Funding Source: researchfish
- MRC [MR/M020126/1] Funding Source: UKRI
- Wellcome Trust [101849/Z/13/Z] Funding Source: Wellcome Trust
Human liver contains an Eomes(hi) population of NK cells that is not present in the blood. In this study, we show that these cells are characterized by a molecular signature that mediates their retention in the liver. By examining liver transplants where donors and recipients are HLA mismatched, we distinguish between donor liver-derived and recipient-derived leukocytes to show that Eomes(lo) NK cells circulate freely whereas Eomes(hi) NK cells are unable to leave the liver. Furthermore, Eomes(hi) NK cells are retained in the liver for up to 13 y. Therefore, Eomes(hi) NK cells are long-lived liver-resident cells. We go on to show that Eomes(hi) NK cells can be recruited from the circulation during adult life and that circulating Eomes(lo) NK cells are able to upregulate Eomes and molecules mediating liver retention under cytokine conditions similar to those in the liver. This suggests that circulating NK cells are a precursor of their liver-resident counterparts.
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