4.4 Article

Lipid Transport by Candida albicans Dnf2 Is Required for Hyphal Growth and Virulence

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Genetics & Heredity

Biallelic truncating variants in ATP9A cause a novel neurodevelopmental disorder involving postnatal microcephaly and failure to thrive

Guido Vogt et al.

Summary: Pathogenic variants in the ATP9A gene cause a novel autosomal recessive neurodevelopmental disorder characterized by postnatal microcephaly. ATP9A plays a crucial role in endosomal transport, with variants leading to a reduction in mRNA expression and altered gene expression of components related to endosomes.

JOURNAL OF MEDICAL GENETICS (2022)

Article Multidisciplinary Sciences

Whole-genome sequencing reveals host factors underlying critical COVID-19

Athanasios Kousathanas et al.

Summary: This study used whole-genome sequencing to compare the genomes of 7,491 critically ill individuals with 48,400 controls, and identified 23 independent variants associated with critical COVID-19. The research found multiple genes that are involved in interferon signaling, leukocyte differentiation, and blood-type antigen secretion to be associated with critical illness.

NATURE (2022)

Article Cell Biology

Conformational changes of a phosphatidylcholine flippase in lipid membranes

Jinkun Xu et al.

Summary: This study reports the cryoelectron microscopy structures of a yeast PC-flipping P4-ATPase, revealing that its conformational state is regulated by lipid composition. In native membranes, the enzyme may stay in an inactive conformation that cannot support lipid translocation.

CELL REPORTS (2022)

Article Medicine, General & Internal

Two Siblings with Cerebellar Ataxia, Mental Retardation, and Disequilibrium Syndrome 4 and a Novel Variant of ATP8A2

Yuta Narishige et al.

Summary: Cerebellar ataxia, mental retardation, and disequilibrium syndrome 4 (CAMRQ4) is an early onset neuromotor disorder and intellectual disabilities caused by variants of ATP8A2. This study reports on sibling cases and analyzes previous literature to increase understanding of CAMRQ4. The patients presented with athetotic movements, ptosis, ophthalmoplegia, and other symptoms, along with auditory and visual impairments.

TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE (2022)

Review Chemistry, Multidisciplinary

Antifungal Drug Resistance: Molecular Mechanisms in Candida albicans and Beyond

Yunjin Lee et al.

Summary: This article discusses the major role of fungal infections in infectious disease-related deaths worldwide, the prevalence of Candida species in invasive mycotic diseases, and the limitations of current antifungal drugs. It also focuses on the resistance mechanisms of Candida species and potential therapeutic strategies to combat antifungal resistance.

CHEMICAL REVIEWS (2021)

Article Multidisciplinary Sciences

Structural basis of the P4B ATPase lipid flippase activity

Lin Bai et al.

Summary: This study reports the structure of the P4B ATPase Neo1 in several states, clarifying its substrate transport mechanism and revealing similar functional intermediate states to dimeric flippases. The findings suggest that evolutionarily distant P4 ATPases use a structurally conserved mechanism for substrate transport.

NATURE COMMUNICATIONS (2021)

Article Genetics & Heredity

Biallelic truncation variants in ATP9A are associated with a novel autosomal recessive neurodevelopmental disorder

Francesca Mattioli et al.

Summary: Intellectual disability is a highly heterogeneous disorder with hundreds of associated genes. Despite progress in identifying genetic causes, half of affected individuals remain undiagnosed. Consanguineous families offer a unique opportunity to discover novel causative genes for neurodevelopmental disorders.

NPJ GENOMIC MEDICINE (2021)

Article Microbiology

P-Type ATPase Apt1 of the Fungal Pathogen Cryptococcus neoformans Is a Lipid Flippase of Broad Substrate Specificity

Lyubomir Dimitrov Stanchev et al.

Summary: Lipid flippases of the P4-ATPase family, particularly the Apt1p in Cryptococcus neoformans, play crucial roles in regulating lipid transport and fungal virulence. Apt1p forms a heterodimeric complex with the Cdc50 protein, which is essential for both transporter complex localization and activity. The lipid flippase activity of this heterodimeric complex exhibits a wide substrate specificity, indicating its potential as a target for antifungal drug development.

JOURNAL OF FUNGI (2021)

Article Multidisciplinary Sciences

Highly accurate protein structure prediction with AlphaFold

John Jumper et al.

Summary: Proteins are essential for life, and accurate prediction of their structures is a crucial research problem. Current experimental methods are time-consuming, highlighting the need for accurate computational approaches to address the gap in structural coverage. Despite recent progress, existing methods fall short of atomic accuracy in protein structure prediction.

NATURE (2021)

Letter Clinical Neurology

Genetic analysis of ATP10B for Parkinson's disease in Japan

Mayu Ishiguro et al.

Summary: Compound heterozygosity of ATP10B is considered a risk factor for young-onset Parkinson's disease, but genetic screening in this study found little evidence of pathogenicity for the identified gene variants in patients with young-onset sporadic PD and autosomal recessive PD.

PARKINSONISM & RELATED DISORDERS (2021)

Article Medicine, Research & Experimental

A sublethal ATP11A mutation associated with neurological deterioration causes aberrant phosphatidylcholine flipping in plasma membranes

Katsumori Segawa et al.

Summary: The study investigates the impact of ATP11A mutation on the distribution of PtdCho and SM and its effects on cell characteristics. The results reveal the physiological importance of substrate specificity of plasma membrane flippases in maintaining proper phospholipid distribution.

JOURNAL OF CLINICAL INVESTIGATION (2021)

Article Cell Biology

Pseudohyphal growth in Saccharomyces cerevisiae involves protein kinase-regulated lipid flippases

Merethe Morch Frosig et al.

JOURNAL OF CELL SCIENCE (2020)

Article Biochemistry & Molecular Biology

Exofacial membrane composition and lipid metabolism regulates plasma membrane P4-ATPase substrate specificity

Bhawik Kumar Jain et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2020)

Article Biochemistry & Molecular Biology

Evolution and a revised nomenclature of P4 ATPases, a eukaryotic family of lipid flippases

Michael Palmgren et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2019)

Article Multidisciplinary Sciences

Structure and autoregulation of a P4-ATPase lipid flippase

Milena Timcenko et al.

NATURE (2019)

Article Multidisciplinary Sciences

Cryo-EM structures capture the transport cycle of the P4-ATPase flippase

Masahiro Hiraizumi et al.

SCIENCE (2019)

Article Multidisciplinary Sciences

Autoinhibition and activation mechanisms of the eukaryotic lipid flippase Drs2p-Cdc50p

Lin Bai et al.

NATURE COMMUNICATIONS (2019)

Article Biochemistry & Molecular Biology

Yeast and human P4-ATPases transport glycosphingolipids using conserved structural motifs

Bartholomew P. Roland et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2019)

Article Genetics & Heredity

Plasma membrane architecture protects Candida albicans from killing by copper

Lois M. Douglas et al.

PLOS GENETICS (2019)

Article Biochemistry & Molecular Biology

The putative flippase Apt1 is required for intracellular membrane architecture and biosynthesis of polysaccharide and lipids in Cryptococcus neoformans

Juliana Rizzo et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2018)

Article Microbiology

Role of Arf GTPases in fungal morphogenesis and virulence

Hayet Labbaoui et al.

PLOS PATHOGENS (2017)

Article Multidisciplinary Sciences

Phospholipid flipping involves a central cavity in P4 ATPases

M. S. Jensen et al.

SCIENTIFIC REPORTS (2017)

Review Biochemistry & Molecular Biology

Decoding P4-ATPase substrate interactions

Bartholomew P. Roland et al.

CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY (2016)

Article Biochemistry & Molecular Biology

The Essential Neo1 Protein from Budding Yeast Plays a Role in Establishing Aminophospholipid Asymmetry of the Plasma Membrane

Mehmet Takar et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2016)

Article Chemistry, Multidisciplinary

Cu2+ Binds to Phosphatidylethanolamine and Increases Oxidation in Lipid Membranes

Matthew F. Poyton et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2016)

Article Multidisciplinary Sciences

SB-224289 Antagonizes the Antifungal Mechanism of the Marine Depsipeptide Papuamide A

Chelsi D. Cassilly et al.

PLOS ONE (2016)

Review Physiology

P4-ATPases as Phospholipid Flippases-Structure, Function, and Enigmas

Jens P. Andersen et al.

FRONTIERS IN PHYSIOLOGY (2016)

Article Microbiology

Role of the Apt1 Protein in Polysaccharide Secretion by Cryptococcus neoformans

Juliana Rizzo et al.

EUKARYOTIC CELL (2014)

Article Multidisciplinary Sciences

Critical roles of isoleucine-364 and adjacent residues in a hydrophobic gate control of phospholipid transport by the mammalian P4-ATPase ATP8A2

Anna L. Vestergaard et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Article Cardiac & Cardiovascular Systems

A gene variant in the Atp10d gene associates with atherosclerotic indices in Japanese elderly population

James Tumaini Kengia et al.

ATHEROSCLEROSIS (2013)

Article Medicine, Research & Experimental

ATP11B mediates platinum resistance in ovarian cancer

Myrthala Moreno-Smith et al.

JOURNAL OF CLINICAL INVESTIGATION (2013)

Article Multidisciplinary Sciences

Two-gate mechanism for phospholipid selection and transport by type IV P-type ATPases

Ryan D. Baldridge et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Review Immunology

Candida albicans pathogenicity mechanisms

Francois L. Mayer et al.

VIRULENCE (2013)

Review Biochemistry & Molecular Biology

Phospholipid flippases: Building asymmetric membranes and transport vesicles

Tessy T. Sebastian et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2012)

Article Chemistry, Multidisciplinary

Phosphatidylserine Reversibly Binds Cu2+ with Extremely High Affinity

Christopher F. Monson et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2012)

Article Multidisciplinary Sciences

Critical role of a transmembrane lysine in aminophospholipid transport by mammalian photoreceptor P4-ATPase ATP8A2

Jonathan A. Coleman et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Article Multidisciplinary Sciences

Identification of residues defining phospholipid flippase substrate specificity of type IV P-type ATPases

Ryan D. Baldridge et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Review Biophysics

P-Type ATPases

Michael G. Palmgren et al.

ANNUAL REVIEW OF BIOPHYSICS, VOL 40 (2011)

Article Multidisciplinary Sciences

ATP8B1 is essential for maintaining normal hearing

Janneke M. Stapelbroek et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Article Genetics & Heredity

Genetic Determinants of Circulating Sphingolipid Concentrations in European Populations

Andrew A. Hicks et al.

PLOS GENETICS (2009)

Article Infectious Diseases

Epidemiology of candidemia in intensive care units

Emilio Bouza et al.

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS (2008)

Article Medicine, Research & Experimental

Glucosylceramide synthase is an essential regulator of pathogenicity of Cryptococcus neoformans

Philipp C. Rittershaus et al.

JOURNAL OF CLINICAL INVESTIGATION (2006)

Article Multidisciplinary Sciences

A P-type ATPase required for rice blast disease and induction of host resistance

MJ Gilbert et al.

NATURE (2006)

Article Multidisciplinary Sciences

Drs2p-coupled aminophospholipid translocase activity in yeast Golgi membranes and relationship to in vivo function

P Natarajan et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)

Review Microbiology

Candida albicans secreted aspartyl proteinases in virulence and pathogenesis

JR Naglik et al.

MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS (2003)

Article Biochemistry & Molecular Biology

Glucosylceramide synthases, a gene family responsible for the biosynthesis of glucosphingolipids in animals, plants, and fungi

M Leipelt et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2001)