期刊
JOURNAL OF IMMUNOLOGY
卷 196, 期 11, 页码 4437-4444出版社
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.1600120
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资金
- National Institutes of Health Institute and Center: National Institute of Allergy and Infectious Diseases
- National Institutes of Health Institute and Center: National Cancer Institute
- National Institutes of Health Institute and Center: National Institute of Mental Health
- National Institutes of Health Institute and Center: National Institute on Drug Abuse
- National Institutes of Health Institute and Center: National Institute of Child Health and Human Development
- National Institutes of Health Institute and Center: National Heart, Lung, and Blood Institute
- National Institutes of Health Institute and Center: National Institute on Aging
- Creative and Novel Ideas in HIV Research grant
- Australian Centre for HIV and Hepatitis Virology Research grant
- National Health and Medical Research Council of Australia Principal Research Fellowship
- Indian Council of Medical Research [ICM 0067]
Immune cells cycle between a resting and an activated state. Their metabolism is tightly linked to their activation status and, consequently, functions. Ag recognition induces T lymphocyte activation and proliferation and acquisition of effector functions that require and depend on cellular metabolic reprogramming. Likewise, recognition of pathogen-associated molecular patterns by monocytes and macrophages induces changes in cellular metabolism. As obligate intracellular parasites, viruses manipulate the metabolism of infected cells to meet their structural and functional requirements. For example, HIV-induced changes in immune cell metabolism and redox state are associated with CD4(+) T cell depletion, immune activation, and inflammation. In this review, we highlight how HIV modifies immunometabolism with potential implications for cure research and pathogenesis of comorbidities observed in HIV-infected patients, including those with virologic suppression. In addition, we highlight recently described key methods that can be applied to study the metabolic dysregulation of immune cells in disease states.
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