期刊
INDUSTRIAL CROPS AND PRODUCTS
卷 183, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.indcrop.2022.114953
关键词
Diabetes mellitus; Hyperglycaemia; Schinus polygamous; Oxidative stress; Cholesterol; Streptozotocin
The study identified phytochemical constituents of Schinus polygamus leaf extract and evaluated its ameliorative effects on oxidative stress and metabolic abnormalities in diabetic rats induced by high-fat diet and streptozotocin. The extract dose-dependently improved body weight gain, insulin resistance, lipid peroxidation, and inflammation while enhancing insulin sensitivity and antioxidant defense system, making it a potential adjuvant candidate in the management of type-2 diabetes.
Diabetes is a life-threatening metabolic disease marked by hyperglycaemia, endocrine system abnormalities, and aberrant lipid metabolic profiles. The study targeted to identify the phytochemical constituents of Schinus pol-ygamus leaf extract (SPLE) and evaluate its ameliorative effects on the oxidative stress and metabolic abnor-malities caused by high-fat diet (HFD) with low dose of streptozotocin (STZ) in male rats. The high-performance liquid chromatography-mass spectrometry (HPLC-MS/MS) analysis of SPLE revealed identification of fourteen compounds of phenolic nature, such as gallic acid, catechin, methyl gallate, pentagalloyl-O-hexoside and cate-chin-O-hexoside. The type-2 diabetic mellitus (T2DM) model was established by HFD and STZ (i.p; 30 mg/kg). The T2DM animals orally administrated two doses of SPLE (200 & 400 mg/kg b.w/day) or metformin (400 mg/ kg/day, orally) for one month. The extract dose-dependently enhanced the body weight gain, BMI, hepatorenal toxicity markers, hyperglycaemia, homeostatic model assessment for insulin resistance (HOMA-IR), insulin level, lipid peroxidation and dyslipidaemia of diabetic rats. It also improved insulin sensitivity and antioxidant defense system. Moreover, it modulated the levels of proinflammatory adipokines (adiponectin & leptin). Further, it downregulated inducible pro-inflammatory genes (NF-kappa B & iNOS mRNA expression). The present study elicited antihyperlipidemic, antihyperglycemic, anti-insulin resistance, anti-inflammatory, antioxidant properties of S. polygamus. Thereby, it could be a new adjuvant candidate in the T2DM management.
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