Anti-psoriasis activities of hydroxytyrosol on HaCaT cells under psoriatic inflammation in vitro

Review Cell Biology

Advances in the pathogenesis of psoriasis: from keratinocyte perspective

Xue Zhou et al.

Summary: This article reviews the crucial role of keratinocytes in the pathogenesis of psoriasis, emphasizing the significance of targeting keratinocytes for the treatment of psoriasis.

CELL DEATH & DISEASE (2022)

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Article Nutrition & Dietetics

Nutritional Therapy in Persons Suffering from Psoriasis

Jagoda Garbicz et al.

Summary: Psoriasis is a chronic inflammatory skin disease with various factors contributing to its pathogenesis, including diet. Changing eating habits can improve patients' quality of life and reduce the risk of other diseases. Recommendations include low-energy diet for overweight individuals, limiting saturated fatty acids and replacing them with anti-inflammatory omega-3 polyunsaturated fatty acids. Antioxidants and vitamin D supplementation are important, along with alternative diets such as gluten-free, vegetarian, and Mediterranean diets that may have a positive effect. Tailoring the diet therapy to pharmacological treatment is also important.

NUTRIENTS (2022)

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Review Dermatology

Psoriasis: Comorbidities

Fumikazu Yamazaki

Summary: Psoriasis used to be considered a skin disease with complications related to diet and obesity, but it is now recognized as a systemic inflammatory disease with cytokines that can induce various other diseases. Individuals with psoriasis have higher incidences of cerebral and cardiovascular diseases and tend to die at a younger age. Clear guidelines have not yet been established for how much vascular lesion testing should be performed in patients with psoriasis.

JOURNAL OF DERMATOLOGY (2021)

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Article Medicine, General & Internal

Psoriasis

Christopher E M Griffiths et al.

LANCET (2021)

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Review Agriculture, Multidisciplinary

Potential of Olive Oil Mill Wastewater as a Source of Polyphenols for the Treatment of Skin Disorders: A Review

Morgane Carrara et al.

Summary: The focus on naturally occurring compounds, particularly olive oil wastewater rich in phenolic compounds, has led to increasing studies on their potential therapeutic benefits in dermatology. Specific attention is given to compounds such as caffeic and ferulic acids, tyrosol and hydroxytyrosol, verbascoside, and oleuropein, which have proven benefits in topical pharmacology. Studies show promising results in the treatment of inflammatory skin diseases, wound healing, antimicrobial effects, and potential as sun protection agents. Further research into the valorization of olive mill waste phenolics for dermatological and dermo-cosmetic applications is strongly supported by existing evidence.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2021)

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Article Medicine, Research & Experimental

Discovery of hydroxytyrosol as thioredoxin reductase 1 inhibitor to induce apoptosis and G1/S cell cycle arrest in human colorectal cancer cells via ROS generation

Sheng-Peng Zhang et al.

Summary: The study found that a natural product called hydroxytyrosol (HT) can potentially serve as an inhibitor for colorectal cancer treatment by inhibiting TrxR1 activity, leading to accumulation of reactive oxygen species and inhibiting tumor cell proliferation while inducing apoptosis.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2021)

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Article Biochemistry & Molecular Biology

Comparative Cytotoxic Activity of Hydroxytyrosol and Its Semisynthetic Lipophilic Derivatives in Prostate Cancer Cells

Antonio J. Leon-Gonzalez et al.

Summary: The study suggests that hydroxytyrosol (HT) and its lipophilic derivatives could be potential therapeutic tools for prostate cancer (PCa) by demonstrating their anti-proliferative and migration inhibitory effects on PCa cell lines.

ANTIOXIDANTS (2021)

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Review Dermatology

Management of psoriasis as a systemic disease: what is the evidence?

N. J. Korman

BRITISH JOURNAL OF DERMATOLOGY (2020)

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Review Biotechnology & Applied Microbiology

Hydroxytyrosol: A natural compound with promising pharmacological activities

Matteo Bertelli et al.

JOURNAL OF BIOTECHNOLOGY (2020)

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Review Medicine, General & Internal

Pathophysiology, Clinical Presentation, and Treatment of Psoriasis A Review

April W. Armstrong et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2020)

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Review Cell Biology

Keratinocyte: A trigger or an executor of psoriasis?

Xinhui Ni et al.

JOURNAL OF LEUKOCYTE BIOLOGY (2020)

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Review Biochemistry & Molecular Biology

Psoriasis and Antimicrobial Peptides

Toshiya Takahashi et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Review Medicine, General & Internal

Antimicrobial peptides: bridging innate and adaptive immunity in the pathogenesis of psoriasis

Jing-Yi Ma et al.

CHINESE MEDICAL JOURNAL (2020)

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Review Biochemistry & Molecular Biology

Psoriasis Pathogenesis and Treatment

Adriana Rendon et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Article Pharmacology & Pharmacy

Safety and efficacy of hydroxytyrosol-based formulation on skin inflammation: in vitro evaluation on reconstructed human epidermis model

Antonella Smeriglio et al.

DARU-JOURNAL OF PHARMACEUTICAL SCIENCES (2019)

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Article Food Science & Technology

Olive-Oil-Derived Polyphenols Effectively Attenuate Inflammatory Responses of Human Keratinocytes by Interfering with the NF-κB Pathway

Marina Aparicio-Soto et al.

MOLECULAR NUTRITION & FOOD RESEARCH (2019)

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Article Cell Biology

Hydroxytyrosol from olive fruits prevents blue-light-induced damage in human keratinocytes and fibroblasts

Rosanna Avola et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2019)

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Article Dermatology

Psoriasis and Depression: The Role of Inflammation

S. Gonzalez-Parra et al.

ACTAS DERMO-SIFILIOGRAFICAS (2019)

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Review Endocrinology & Metabolism

Anti-inflammatory Activity of Extra Virgin Olive Oil Polyphenols: Which Role in the Prevention and Treatment of Immune-Mediated Inflammatory Diseases?

Carmela Santangelo et al.

ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS (2018)

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Article Clinical Neurology

Systemic inflammation in asocial BTBR T+ tf/J mice predisposes them to increased psoriatic inflammation

Ahmed Nadeem et al.

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY (2018)

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Article Food Science & Technology

Dietary hydroxytyrosol and hydroxytyrosyl acetate supplementation prevent pristane-induced systemic lupus erythematous in mice

Marina Aparicio-Soto et al.

JOURNAL OF FUNCTIONAL FOODS (2017)

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Review Nutrition & Dietetics

Hydroxytyrosol in the Prevention of the Metabolic Syndrome and Related Disorders

Julien Peyrol et al.

NUTRIENTS (2017)

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Article Cell Biology

GPR43 activation enhances psoriasis-like inflammation through epidermal upregulation of IL-6 and dual oxidase 2 signaling in a murine model

Ahmed Nadeem et al.

CELLULAR SIGNALLING (2017)

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Article Pharmacology & Pharmacy

Psoriatic inflammation enhances allergic airway inflammation through IL-23/STAT3 signaling in a murine model

Ahmed Nadeem et al.

BIOCHEMICAL PHARMACOLOGY (2017)

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Review Biochemistry & Molecular Biology

Extra virgin olive oil: a key functional food for prevention of immune-inflammatory diseases

Marina Aparicio-Soto et al.

FOOD & FUNCTION (2016)

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Article Immunology

Stimulation of the histamine 4 receptor with 4-methylhistamine modulates the effects of chronic stress on the Th1/Th2 cytokine balance

Sheikh Fayaz Ahmad et al.

IMMUNOBIOLOGY (2015)

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Article Dermatology

Evaluating the economic burden of psoriasis in the United States

Jacqueline Vanderpuye-Orgle et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2015)

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Article Medicine, Research & Experimental

Nutrition and psoriasis: is there any association between the severity of the disease and adherence to the Mediterranean diet?

Luigi Barrea et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2015)

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Review Pharmacology & Pharmacy

NF-κβ signaling and chronic inflammatory diseases: exploring the potential of natural products to drive new therapeutic opportunities

Matthew J. Killeen et al.

DRUG DISCOVERY TODAY (2014)

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Review Immunology

The New Insight into the Role of Antimicrobial Proteins-Alarmins in the Immunopathogenesis of Psoriasis

A. Batycka-Baran et al.

JOURNAL OF IMMUNOLOGY RESEARCH (2014)

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Article Food Science & Technology

Toxicological evaluation of pure hydroxytyrosol

David Aunon-Calles et al.

FOOD AND CHEMICAL TOXICOLOGY (2013)

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Article Pharmacology & Pharmacy

Hydroxytyrosol is not genotoxic in vitro

David Aunon-Calles et al.

PHARMACOLOGICAL RESEARCH (2013)

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Article Genetics & Heredity

Investigation into the biological properties of the olive polyphenol, hydroxytyrosol: mechanistic insights by genome-wide mRNA-Seq analysis

Haloom Rafehi et al.

GENES AND NUTRITION (2012)

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Article Immunology

Skin Inflammation Induced by the Synergistic Action of IL-17A, IL-22, Oncostatin M, IL-1α, and TNF-α Recapitulates Some Features of Psoriasis

Karline Guilloteau et al.

JOURNAL OF IMMUNOLOGY (2010)

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Article Chemistry, Medicinal

The Protective Effects of Hydroxytyrosol Against UVB-induced DNA Damage in HaCaT cells

Wei Guo et al.

PHYTOTHERAPY RESEARCH (2010)

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Anti-psoriasis activities of hydroxytyrosol on HaCaT cells under psoriatic inflammation in vitro

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