The role of neutrophils in trained immunity

Review Physiology

Inflammatory Modulation of Hematopoiesis: Linking Trained Immunity and Clonal Hematopoiesis with Chronic Disorders

Triantafyllos Chavakis et al.

Summary: Inflammation-adapted hematopoietic stem and progenitor cells play a crucial role in emergency myelopoiesis, trained immunity, and clonal hematopoiesis. Modulation of HSPC function could lead to novel therapeutic interventions.

ANNUAL REVIEW OF PHYSIOLOGY (2022)

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Article Biochemistry & Molecular Biology

Maladaptive innate immune training of myelopoiesis links inflammatory comorbidities

Xiaofei Li et al.

Summary: Bone marrow-mediated trained innate immunity can enhance immune responsiveness, but maladaptive training can lead to inflammatory comorbidities. Periodontitis can induce maladaptive trained phenotype in the bone marrow, resulting in increased production of myeloid cells with inflammatory preparedness. The trained phenotype of the bone marrow can be transmitted to naive recipients through transplantation and lead to increased inflammatory responsiveness and disease severity. Inhibiting IL-1 signaling can prevent maladaptive training caused by periodontitis.

CELL (2022)

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Article Cell Biology

Induction of memory-like adaptive responses in murine neutrophils in vitro

Trim Lajqi et al.

Summary: Innate immune cells have the potential to develop immunological memory through a process called trained immunity. This process is characterized by increased production of inflammatory mediators and changes in cellular functions. We have established a two-hit stimulation protocol in vitro to induce memory-like responses in murine bone marrow neutrophils. This protocol can be used to study the evolving field of memory-like innate immunity. Pathogen-associated molecular patterns (PAMPs) promote dose-dependent contrasting memory-like responses.

CELLULAR IMMUNOLOGY (2022)

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Article Immunology

CD66b-CD64dimCD115- cells in the human bone marrow represent neutrophil-committed progenitors

Federica Calzetti et al.

Summary: Cassatella and colleagues have identified the earliest neutrophil-committed progenitor cells in the human bone marrow. These cells share similar characteristics with mature neutrophil subsets expressing interferon-stimulated genes in diseased individuals. This discovery sheds light on the early stages of neutrophil development and is of significant importance.

NATURE IMMUNOLOGY (2022)

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Review Dentistry, Oral Surgery & Medicine

Maladaptive trained immunity and clonal hematopoiesis as potential mechanistic links between periodontitis and inflammatory comorbidities

George Hajishengallis et al.

Summary: This article reviews the bidirectional association between periodontitis and systemic inflammatory disorders. It introduces two newly emerged concepts, trained innate immunity (TII) and clonal hematopoiesis of indeterminate potential (CHIP), which together support a potential hypothesis on how periodontitis affects and is affected by comorbidities and why the susceptibility to periodontitis and comorbidities increases with aging. The article discusses the role of TII and CHIP in mediating the relationship between periodontitis and comorbidities, and proposes that a mechanistic understanding of this connection may lead to novel diagnostic and therapeutic targets for inflammatory comorbidities.

PERIODONTOLOGY 2000 (2022)

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Editorial Material Immunology

Inflammatory comorbidities: to train or not to train?

Suhas Bobba et al.

Summary: Inflammatory stimuli have a lasting impact on innate immune cells, leading to intensified responses when encountering future challenges. This trained immunity is mediated by hematopoietic stem cells in the bone marrow and is mechanistically linked to inflammatory comorbidities.

TRENDS IN IMMUNOLOGY (2022)

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Article Oncology

Imprime PGG Enhances Anti-Tumor Effects of Tumor-Targeting, Anti-Angiogenic, and Immune Checkpoint Inhibitor Antibodies

Anissa S. H. Chan et al.

Summary: Imprime is a late-stage clinical development drug with multiple therapeutic modalities that can activate innate immune cells and elicit broad immune responses. In mouse models, Imprime showed synergistic therapeutic effects on various cancer types.

FRONTIERS IN ONCOLOGY (2022)

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Article Dentistry, Oral Surgery & Medicine

Mechanisms and Therapeutic Modulation of Neutrophil-Mediated Inflammation

G. Hajishengallis et al.

Summary: Neutrophils are important cells that play a role in both inflammatory response and maintaining tissue homeostasis. They can be both protective and destructive, depending on the context. Local tissue factors and systemic metabolic conditions can regulate the activity and production of neutrophils. Targeted therapeutic interventions can be developed based on current insights to restrain neutrophil-mediated inflammation in chronic inflammatory diseases.

JOURNAL OF DENTAL RESEARCH (2022)

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Review Immunology

The Roles of Neutrophils Linking Periodontitis and Atherosclerotic Cardiovascular Diseases

Rizky A. Irwandi et al.

Summary: Inflammation plays a crucial role in the development of atherosclerosis, and periodontitis is linked to this chronic inflammatory disease. Neutrophils play an important role in mediating the relationship between periodontitis and atherosclerosis. Systemic inflammation triggered by periodontitis can lead to the overproduction and hyper-responsiveness of neutrophils, contributing to the progression of atherosclerosis.

FRONTIERS IN IMMUNOLOGY (2022)

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Review Immunology

Neutrophils in homeostasis and tissue repair

Hanjoo Brian Shim et al.

Summary: Neutrophils, previously believed to be short-lived killer cells, are now recognized to have more complex functions, including tissue homeostasis and repair.

INTERNATIONAL IMMUNOLOGY (2022)

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Review Immunology

Neutrophils in cancer: heterogeneous and multifaceted

Catherine C. Hedrick et al.

Summary: Neutrophils have emerged as important regulators of cancer, revealing their diverse and plastic contributions in tumor development and growth, influencing positively and negatively depending on time, place, and disease context. Their functional importance in cancer has been overlooked due to their short-lived, terminally differentiated, and non-proliferative characteristics, but recent studies have led to a paradigm shift in understanding their roles.

NATURE REVIEWS IMMUNOLOGY (2022)

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Review Biochemistry & Molecular Biology

Immunometabolic control of hematopoiesis

George Hajishengallis et al.

Summary: Hematopoietic stem cells play a central role in hematopoiesis by regulating the immune system, responding to stress, and modulating their function and fate through metabolic pathways. Specific metabolic alterations are associated with HSPC dysfunction and trained myelopoiesis.

MOLECULAR ASPECTS OF MEDICINE (2021)

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Article Multidisciplinary Sciences

Trained innate immunity, long-lasting epigenetic modulation, and skewed myelopoiesis by heme

Elisa Jentho et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

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Review Immunology

Immune Regulation in Time and Space: The Role of Local- and Long-Range Genomic Interactions in Regulating Immune Responses

Liam P. Devenish et al.

Summary: Mammalian immune cells need to respond rapidly and effectively to different challenges to combat pathogens, with cellular heterogeneity and changes in genome structures playing crucial roles in regulating immune responses.

FRONTIERS IN IMMUNOLOGY (2021)

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Review Immunology

Bacillus Calmette-Guerin Immunotherapy for Cancer

Fabiola Cardillo et al.

Summary: BCG vaccine, originally developed for tuberculosis prevention, has shown success in immunotherapy for bladder cancer and other neoplasms. By stimulating immune response, blocking checkpoint inhibitory molecules, and using TLR agonists, BCG has demonstrated efficacy in treating various tumors.

VACCINES (2021)

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Article Biochemistry & Molecular Biology

LPS Induces Opposing Memory-like Inflammatory Responses in Mouse Bone Marrow Neutrophils

Trim Lajqi et al.

Summary: Studies have shown that neutrophils can exhibit trained immunity and tolerance. Through in vivo and in vitro experiments, researchers found that different doses of lipopolysaccharide can lead to varying effects, potentially related to inflammatory responses.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Immunology

Trained Immunity Confers Prolonged Protection From Listeriosis

Charlotte Theroude et al.

Summary: Trained immunity induced by beta-glucan training can confer long-term protection against lethal bacterial infections by increasing cytokine levels, antimicrobial activity, cell migration, and metabolic activity of white blood cells. The study suggests that training enhances the generation and antimicrobial activity of white blood cells, providing prolonged protection against lethal bacterial infections.

FRONTIERS IN IMMUNOLOGY (2021)

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Review Biochemistry & Molecular Biology

Pattern recognition receptors in health and diseases

Danyang Li et al.

Summary: Pattern recognition receptors (PRRs) are a class of receptors that can directly recognize specific molecular structures on pathogens, apoptotic host cells, and damaged senescent cells, bridging nonspecific immunity and specific immunity. Through the recognition and binding of ligands, PRRs can produce immunoprotective effects against infections and tumors. Research on PRRs and their ligands has greatly enhanced understanding of the signaling pathways involved, providing insights for the treatment of immune-related diseases and tumors.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

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Review Nutrition & Dietetics

Fungal beta-glucans as adjuvants for treating cancer patients-A systematic review of clinical trials

Laiza Steimbach et al.

Summary: Fungal fi-glucans have potential as adjuvants in cancer treatment by stimulating the immune system, but further research is needed to determine their efficacy due to the diversity in methodology and insufficient information.

CLINICAL NUTRITION (2021)

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Review Immunology

Local and systemic mechanisms linking periodontal disease and inflammatory comorbidities

George Hajishengallis et al.

Summary: Periodontitis is causally linked to the development of other chronic inflammatory diseases outside the oral mucosa, and intervention studies have shown that local treatment of periodontitis can ameliorate surrogate markers of comorbid conditions. Experimental animal studies have further strengthened the potential causal link by establishing biologically plausible and clinically consistent mechanisms. Understanding the impact of disseminated periodontal pathogens and systemic inflammation associated with periodontitis on extra-oral pathologies may lead to new therapeutic options to reduce the risk of periodontitis-associated comorbidities.

NATURE REVIEWS IMMUNOLOGY (2021)

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Article Immunology

Trained Immunity Confers Broad-Spectrum Protection Against Bacterial Infections

Eleonora Ciarlo et al.

JOURNAL OF INFECTIOUS DISEASES (2020)

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Article Cell & Tissue Engineering

C/EBPβ-Dependent Epigenetic Memory Induces Trained Immunity in Hematopoietic Stem Cells

Berengere de Laval et al.

CELL STEM CELL (2020)

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Article Cardiac & Cardiovascular Systems

Catecholamines Induce Trained Immunity in Monocytes In Vitro and In Vivo

Charlotte D. C. C. van der Heijden et al.

CIRCULATION RESEARCH (2020)

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Article Cell Biology

β-Glucan Induces Protective Trained Immunity against Mycobacterium tuberculosis Infection: A Key Role for IL-1

Simone J. C. F. M. Moorlag et al.

CELL REPORTS (2020)

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Article Microbiology

New live attenuated tuberculosis vaccine MTBVAC induces trained immunity and confers protection against experimental lethal pneumonia

Raquel Tarancón et al.

PLoS Pathogens (2020)

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Article Immunology

LXR Activation Induces a Proinflammatory Trained Innate Immunity-Phenotype in Human Monocytes

Yahya Sohrabi et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Article Microbiology

BCG Vaccination in Humans Elicits Trained Immunity via the Hematopoietic Progenitor Compartment

Branko Cirovic et al.

CELL HOST & MICROBE (2020)

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Article Immunology

Combinatorial Single-Cell Analyses of Granulocyte-Monocyte Progenitor Heterogeneity Reveals an Early Uni-potent Neutrophil Progenitor

Immanuel Kwok et al.

IMMUNITY (2020)

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Review Immunology

Regulation of the Bone Marrow Niche by Inflammation

Ioannis Mitroulis et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Editorial Material Genetics & Heredity

Long Non-coding RNAs in the Regulation of the Immune Response and Trained Immunity

Manuel Flores-Concha et al.

FRONTIERS IN GENETICS (2020)

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Review Medicine, Research & Experimental

Mechanisms of BCG in the treatment of bladder cancer-current understanding and the prospect

Jiansong Han et al.

BIOMEDICINE & PHARMACOTHERAPY (2020)

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Article Biochemistry & Molecular Biology

Co-option of Neutrophil Fates by Tissue Environments

Ivan Ballesteros et al.

CELL (2020)

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Article Immunology

Single-cell transcriptome profiling reveals neutrophil heterogeneity in homeostasis and infection

Xuemei Xie et al.

NATURE IMMUNOLOGY (2020)

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Article Immunology

Coexpression of CD71 and CD117 Identifies an Early Unipotent Neutrophil Progenitor Population in Human Bone Marrow

Huy Q. Dinh et al.

IMMUNITY (2020)

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Review Genetics & Heredity

The evolving metabolic landscape of chromatin biology and epigenetics

Ziwei Dai et al.

NATURE REVIEWS GENETICS (2020)

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Review Oncology

Neutrophils as Orchestrators in Tumor Development and Metastasis Formation

Lydia Kalafati et al.

FRONTIERS IN ONCOLOGY (2020)

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Article Biology

Reprogramming of bone marrow myeloid progenitor cells in patients with severe coronary artery disease

Marlies P. Noz et al.

ELIFE (2020)

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Article Cell Biology

BCG Vaccination Induces Long-Term Functional Reprogramming of Human Neutrophils

Simone J. C. F. M. Moorlag et al.

CELL REPORTS (2020)

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Article Biochemistry & Molecular Biology

M. tuberculosis Reprograms Hematopoietic Stem Cells to Limit Myelopoiesis and Impair Trained Immunity

Nargis Khan et al.

CELL (2020)

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Article Biochemistry & Molecular Biology

Innate Immune Training of Granulopoiesis Promotes Anti-tumor Activity

Lydia Kalafati et al.

CELL (2020)

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Article Biochemistry & Molecular Biology

Trained Immunity-Promoting Nanobiologic Therapy Suppresses Tumor Growth and Potentiates Checkpoint Inhibition

Bram Priem et al.

CELL (2020)

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Article Immunology

Neutrophil extracellular traps (NETs)-mediated killing of carbapenem-resistant hypervirulentKlebsiella pneumoniae(CR-hvKP) are impaired in patients with diabetes mellitus

Longyang Jin et al.

VIRULENCE (2020)

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Review Immunology

Defining trained immunity and its role in health and disease

Mihai G. Netea et al.

NATURE REVIEWS IMMUNOLOGY (2020)

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Review Hematology

Neutrophils and NETs in modulating acute and chronic inflammation

Fernanda V. S. Castanheira et al.

BLOOD (2019)

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Review Hematology

Neutrophil plasticity in the tumor microenvironment

Morgan A. Giese et al.

BLOOD (2019)

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Review Immunology

Induction of innate immune memory: the role of cellular metabolism

Jorge Dominguez-Andres et al.

CURRENT OPINION IN IMMUNOLOGY (2019)

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Review Immunology

Emerging Principles in Myelopoiesis at Homeostasis and during Infection and Inflammation

Joachim L. Schultze et al.

IMMUNITY (2019)

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Article Multidisciplinary Sciences

Outcomes of controlled human malaria infection after BCG vaccination

Jona Walk et al.

NATURE COMMUNICATIONS (2019)

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Article Multidisciplinary Sciences

Novel reprogramming of neutrophils modulates inflammation resolution during atherosclerosis

Shuo Geng et al.

SCIENCE ADVANCES (2019)

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Article Immunology

BCG-induced formation of neutrophil extracellular traps play an important role in bladder cancer treatment

Kangkang Liu et al.

CLINICAL IMMUNOLOGY (2019)

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Review Immunology

The Neutrophil Life Cycle

Andres Hidalgo et al.

TRENDS IN IMMUNOLOGY (2019)

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Letter Cell Biology

Treatment with Statins Does Not Revert Trained Immunity in Patients with Familial Hypercholesterolemia

Siroon Bekkering et al.

CELL METABOLISM (2019)

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Review Biochemistry & Molecular Biology

Yeast-Derived β-Glucan in Cancer: Novel Uses of a Traditional Therapeutic

Anne Geller et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Review Immunology

Adaptation and memory in immune responses

Gioacchino Natoli et al.

NATURE IMMUNOLOGY (2019)

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Review Immunology

Hematopoietic progenitor cells as integrative hubs for adaptation to and fine-tuning of inflammation

Triantafyllos Chavakis et al.

NATURE IMMUNOLOGY (2019)

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Letter Cardiac & Cardiovascular Systems

Periodontal Disease Associates With Arterial Inflammation Via Potentiation of a Hematopoietic-Arterial Axis

Amorina Ishai et al.

JACC-CARDIOVASCULAR IMAGING (2019)

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Article Pathology

DAMPs, PAMPs, and LAMPs in Immunity and Sterile Inflammation

Joel Zindel et al.

Annual Review of Pathology-Mechanisms of Disease (2019)

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Review Microbiology

Innate and Adaptive Immune Memory: an Evolutionary Continuum in the Host's Response to Pathogens

Mihai G. Netea et al.

CELL HOST & MICROBE (2019)

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Article Cell Biology

The Itaconate Pathway Is a Central Regulatory Node Linking Innate Immune Tolerance and Trained Immunity

Jorge Dominguez-Andres et al.

CELL METABOLISM (2019)

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Article Genetics & Heredity

Immune genes are primed for robust transcription by proximal long noncoding RNAs located in nuclear compartments

Stephanie Fanucchi et al.

NATURE GENETICS (2019)

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Review Medicine, General & Internal

Acute Infection and Myocardial Infarction

Daniel M. Musher et al.

NEW ENGLAND JOURNAL OF MEDICINE (2019)

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Review Immunology

Immunometabolic Crosstalk: An Ancestral Principle of Trained Immunity?

Sider Penkov et al.

TRENDS IN IMMUNOLOGY (2019)

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Review Cell Biology

Lnc-ing Trained Immunity to Chromatin Architecture

Stephanie Fanucchi et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2019)

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Editorial Material Immunology

The Western lifestyle has lasting effects on metaflammation

Anette Christ et al.

NATURE REVIEWS IMMUNOLOGY (2019)

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Review Immunology

Itaconate: the poster child of metabolic reprogramming in macrophage function

Luke A. J. O'Neill et al.

NATURE REVIEWS IMMUNOLOGY (2019)

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Article Biochemistry & Molecular Biology

Western Diet Triggers NLRP3-Dependent Innate Immune Reprogramming

Anette Christ et al.

CELL (2018)

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Article Biochemistry & Molecular Biology

Modulation of Myelopoiesis Progenitors Is an Integral Component of Trained Immunity

Ioannis Mitroulis et al.

CELL (2018)

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Article Biochemistry & Molecular Biology

BCG Educates Hematopoietic Stem Cells to Generate Protective Innate Immunity against Tuberculosis

Eva Kaufmann et al.

CELL (2018)

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Article Biochemistry & Molecular Biology

Metabolic Induction of Trained Immunity through the Mevalonate Pathway

Siroon Bekkering et al.

CELL (2018)

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Article Microbiology

BCG Vaccination Protects against Experimental Viral Infection in Humans through the Induction of Cytokines Associated with Trained Immunity

Rob J. W. Arts et al.

CELL HOST & MICROBE (2018)

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Article Cardiac & Cardiovascular Systems

Trained Innate Immunity as a Novel Mechanism Linking Infection and the Development of Atherosclerosis

Jenneke Leentjens et al.

CIRCULATION RESEARCH (2018)

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Article Immunology

Developmental Analysis of Bone Marrow Neutrophils Reveals Populations Specialized in Expansion, Trafficking, and Effector Functions

Maximilien Evrard et al.

IMMUNITY (2018)

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Article Immunology

Cutting Edge: Plasmodium falciparum Induces Trained Innate Immunity

Jacob E. Schrum et al.

JOURNAL OF IMMUNOLOGY (2018)

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Article Immunology

Neonatal BCG Vaccination Influences Cytokine Responses to Toll-like Receptor Ligands and Heterologous Antigens

Bridget Freyne et al.

JOURNAL OF INFECTIOUS DISEASES (2018)

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Review Immunology

Myelopoiesis in the Context of Innate Immunity

Ioannis Mitroulis et al.

JOURNAL OF INNATE IMMUNITY (2018)

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Review Physiology

Neutrophil: A Cell with Many Roles in Inflammation or Several Cell Types?

Carlos Rosales

FRONTIERS IN PHYSIOLOGY (2018)

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Article Oncology

A randomized, controlled trial evaluating the efficacy and safety of BTH1677 in combination with bevacizumab, carboplatin, and paclitaxel in first-line treatment of advanced non-small cell lung cancer

Walburga Engel-Riedel et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2018)

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Article Multidisciplinary Sciences

Electrophilic properties of itaconate and derivatives regulate the I kappa B zeta-ATF3 inflammatory axis

Monika Bambouskova et al.

NATURE (2018)

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Article Multidisciplinary Sciences

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

Evanna L. Mills et al.

NATURE (2018)

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Article Multidisciplinary Sciences

Interferon stimulation creates chromatin marks and establishes transcriptional memory

Rui Kamada et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

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Article Cell Biology

Identification of an Early Unipotent Neutrophil Progenitor with Pro-tumoral Activity in Mouse and Human Bone Marrow

Yanfang Peipei Zhu et al.

CELL REPORTS (2018)

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Review Microbiology

The oral microbiota: dynamic communities and host interactions

Richard J. Lamont et al.

NATURE REVIEWS MICROBIOLOGY (2018)

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Article Multidisciplinary Sciences

Experimental evolution of a fungal pathogen into a gut symbiont

Gloria Hoi Wan Tso et al.

SCIENCE (2018)

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Review Multidisciplinary Sciences

From haematopoietic stem cells to complex differentiation landscapes

Elisa Laurenti et al.

NATURE (2018)

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Review Immunology

Neutrophils in Homeostasis, Immunity, and Cancer

Jose Angel Nicolas-Avila et al.

IMMUNITY (2017)

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Article Immunology

The infarcted myocardium solicits GM-CSF for the detrimental oversupply of inflammatory leukocytes

Atsushi Anzai et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2017)

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Article Multidisciplinary Sciences

Uric acid priming in human monocytes is driven by the AKT-PRAS40 autophagy pathway

Tania O. Crisan et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

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Article Immunology

α-ketoglutarate orchestrates macrophage activation through metabolic and epigenetic reprogramming

Pu-Ste Liu et al.

NATURE IMMUNOLOGY (2017)

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Article Immunology

S100-alarmin-induced innate immune programming protects newborn infants from sepsis

Thomas Ulas et al.

NATURE IMMUNOLOGY (2017)

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Article Rheumatology

Soluble uric acid primes TLR-induced proinflammatory cytokine production by human primary cells via inhibition of IL-1Ra

Tania O. Crisan et al.

ANNALS OF THE RHEUMATIC DISEASES (2016)

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Article Cardiac & Cardiovascular Systems

Innate immune cell activation and epigenetic remodeling in symptomatic and asymptomatic atherosclerosis in humans in vivo

Siroon Bekkering et al.

ATHEROSCLEROSIS (2016)

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Article Hematology

Aged neutrophils contribute to the first line of defense in the acute inflammatory response

Bernd Uhl et al.

BLOOD (2016)

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Article Biochemistry & Molecular Biology

β-Glucan Reverses the Epigenetic State of LPS-Induced Immunological Tolerance

Boris Novakovic et al.

CELL (2016)

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Article Cell Biology

Glutaminolysis and Fumarate Accumulation Integrate Immunometabolic and Epigenetic Programs in Trained Immunity

Rob J. W. Arts et al.

CELL METABOLISM (2016)

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Article Cardiac & Cardiovascular Systems

Oxidized Phospholipids on Lipoprotein(a) Elicit Arterial Wall Inflammation and an Inflammatory Monocyte Response in Humans

Fleur M. van der Valk et al.

CIRCULATION (2016)

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Article Dentistry, Oral Surgery & Medicine

Neutrophil superoxide release and plasma C-reactive protein levels pre- and post-periodontal therapy

Martin R. Ling et al.

JOURNAL OF CLINICAL PERIODONTOLOGY (2016)

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Article Cell Biology

Chronic interleukin-1 exposure drives haematopoietic stem cells towards precocious myeloid differentiation at the expense of self-renewal

Eric M. Pietras et al.

NATURE CELL BIOLOGY (2016)

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Review Multidisciplinary Sciences

Trained immunity: A program of innate immune memory in health and disease

Mihai G. Netea et al.

SCIENCE (2016)

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Review Medicine, General & Internal

Association of BCG, DTP, and measles containing vaccines with childhood mortality: systematic review

Julian P. T. Higgins et al.

BMJ-BRITISH MEDICAL JOURNAL (2016)

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Article Cell Biology

Immunometabolic Pathways in BCG-Induced Trained Immunity

Rob J. W. Arts et al.

CELL REPORTS (2016)

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Article Cell Biology

Chronic Infection Depletes Hematopoietic Stem Cells through Stress-Induced Terminal Differentiation

Katie A. Matatall et al.

CELL REPORTS (2016)

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Review Medicine, General & Internal

Association of BCG, DTP, and measles containing vaccines with childhood mortality: systematic review

Julian P. T. Higgins et al.

BMJ-BRITISH MEDICAL JOURNAL (2016)

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Article Rheumatology

Unexpected arterial wall and cellular inflammation in patients with rheumatoid arthritis in remission using biological therapy: a cross-sectional study

Sophie J. Bernelot Moens et al.

ARTHRITIS RESEARCH & THERAPY (2016)

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Article Public, Environmental & Occupational Health

Child survival and BCG vaccination: a community based prospective cohort study in Uganda

Victoria Nankabirwa et al.

BMC PUBLIC HEALTH (2015)

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Article Cardiac & Cardiovascular Systems

Targeting Interleukin-1β Reduces Leukocyte Production After Acute Myocardial Infarction

Hendrik B. Sager et al.

CIRCULATION (2015)

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Article Immunology

The Effect of Oral Polio Vaccine at Birth on Infant Mortality: A Randomized Trial

Najaaraq Lund et al.

CLINICAL INFECTIOUS DISEASES (2015)

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Article Biochemistry & Molecular Biology

Peripheral blood neutrophil cytokine hyper-reactivity in chronic periodontitis

Martin R. Ling et al.

INNATE IMMUNITY (2015)

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Article Oncology

Early treatment of high risk chronic lymphocytic leukemia with alemtuzumab, rituximab and poly-(1-6)-beta-glucotriosyl-(1-3)-beta- glucopyranose beta- glucan is well tolerated and achieves high complete remission rates

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Neutrophil ageing is regulated by the microbiome

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Diabetes primes neutrophils to undergo NETosis, which impairs wound healing

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NATURE MEDICINE (2015)

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Trained immunity in newborn infants of HBV-infected mothers

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NATURE COMMUNICATIONS (2015)

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Review Immunology

Cholesterol, inflammation and innate immunity

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NATURE REVIEWS IMMUNOLOGY (2015)

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Review Immunology

Chromatin Contributions to the Regulation of Innate Immunity

Stephen T. Smale et al.

ANNUAL REVIEW OF IMMUNOLOGY, VOL 32 (2014)

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Article Hematology

Oxidized Low-Density Lipoprotein Induces Long-Term Proinflammatory Cytokine Production and Foam Cell Formation via Epigenetic Reprogramming of Monocytes

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ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2014)

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Review Biochemistry & Molecular Biology

Role of the Microbiota in Immunity and Inflammation

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Trained Immunity or Tolerance: Opposing Functional Programs Induced in Human Monocytes after Engagement of Various Pattern Recognition Receptors

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CLINICAL AND VACCINE IMMUNOLOGY (2014)

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Article Immunology

BCG-induced trained immunity in NK cells: Role for non-specific protection to infection

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CLINICAL IMMUNOLOGY (2014)

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Article Immunology

Innate lymphoid cells integrate stromal and immunological signals to enhance antibody production by splenic marginal zone B cells

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NATURE IMMUNOLOGY (2014)

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The microbiota regulates neutrophil homeostasis and host resistance to Escherichia coli K1 sepsis in neonatal mice

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NATURE MEDICINE (2014)

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The mechanism of action of BCG therapy for bladder cancer-a current perspective

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NATURE REVIEWS UROLOGY (2014)

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Microbiota-Dependent Crosstalk Between Macrophages and ILC3 Promotes Intestinal Homeostasis

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SCIENCE (2014)

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mTOR- and HIF-1α-mediated aerobic glycolysis as metabolic basis for trained immunity

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SCIENCE (2014)

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Epigenetic programming of monocyte-to-macrophage differentiation and trained innate immunity

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Diet-induced obesity promotes myelopoiesis in hematopoietic stem cells

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Review Immunology

Emergency granulopoiesis

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NATURE REVIEWS IMMUNOLOGY (2014)

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Annual Review of Pathology-Mechanisms of Disease (2013)

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Rhythmic Modulation of the Hematopoietic Niche through Neutrophil Clearance

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Hyperglycemia Promotes Myelopoiesis and Impairs the Resolution of Atherosclerosis

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Microbiota signalling through MyD88 is necessary for a systemic neutrophilic inflammatory response

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M-CSF instructs myeloid lineage fate in single haematopoietic stem cells

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A small jab - a big effect: nonspecific immunomodulation by vaccines

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Neutrophil Function: From Mechanisms to Disease

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ANNUAL REVIEW OF IMMUNOLOGY, VOL 30 (2012)

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Candida albicans Infection Affords Protection against Reinfection via Functional Reprogramming of Monocytes

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Metaboloepigenetics: Interrelationships between energy metabolism and epigenetic control of gene expression

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JOURNAL OF CELLULAR PHYSIOLOGY (2012)

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Myocardial infarction accelerates atherosclerosis

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Bacille Calmette-Guerin induces NOD2-dependent nonspecific protection from reinfection via epigenetic reprogramming of monocytes

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

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Cancers predispose neutrophils to release extracellular DNA traps that contribute to cancer-associated thrombosis

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

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Trained Immunity: A Memory for Innate Host Defense

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ApoE regulates hematopoietic stem cell proliferation, monocytosis, and monocyte accumulation in atherosclerotic lesions in mice

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Neutrophil clearance: when the party is over, clean-up begins

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TLR-dependent T cell activation in autoimmunity

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Inflammatory modulation of HSCs: viewing the HSC as a foundation for the immune response

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NATURE REVIEWS IMMUNOLOGY (2011)

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Review Immunology

Neutrophils in the activation and regulation of innate and adaptive immunity

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In vivo labeling with 2H2O reveals a human neutrophil lifespan of 5.4 days

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JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2010)

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Recognition of peptidoglycan from the microbiota by Nod1 enhances systemic innate immunity

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ATP-Binding Cassette Transporters and HDL Suppress Hematopoietic Stem Cell Proliferation

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Review Pathology

Combined yeast-derived β-glucan with anti-tumor monoclonal antibody for cancer immunotherapy

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EXPERIMENTAL AND MOLECULAR PATHOLOGY (2009)

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Risk of lymphoma and leukaemia after bacille Calmette-Guerin and smallpox vaccination: A Danish case-cohort study

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Nature, Nurture, or Chance: Stochastic Gene Expression and Its Consequences

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Yeast-derived β-glucan augments the therapeutic efficacy mediated by anti-vascular endothelial growth factor monoclonal antibody in human carcinoma xenograft models

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Homeostatic regulation of blood neutrophil counts

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Role of neutrophils in BCG immunotherapy for bladder cancer

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Combined yeast β-glucan and antitumor monoclonal antibody therapy requires C5a-mediated neutrophil chemotaxis via regulation of decay-accelerating factor CD55

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DAMPs, PAMPs and alarmins: all we need to know about danger

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Toll-like receptors on hematopoietic progenitor cells stimulate innate immune system replenishment

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Neutrophil β2 integrins:: moderators of life or death decisions

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TRENDS IN IMMUNOLOGY (2005)

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C5a-mediated leukotriene B4-amplified neutrophil chemotaxis is essential in tumor immunotherapy facilitated by anti-tumor monoclonal antibody and β-Glucan

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Review Biotechnology & Applied Microbiology

Yeast whole glucan particle (WGP) β-glucan in conjunction with antiturnour monoclonal antibodies to treat cancer

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EXPERT OPINION ON BIOLOGICAL THERAPY (2005)

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Mechanism by which orally administered β-1,3-glucans enhance the tumoricidal activity of antitumor monoclonal antibodies in murine tumor models

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BCG scar and positive tuberculin reaction associated with reduced child mortality in West Africa -: A non-specific beneficial effect of BCG?

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Selective roles for toll-like receptor (TLR)2 and TLR4 in the regulation of neutrophil activation and life span

I Sabroe et al.

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Orally administered β-glucans enhance anti-tumor effects of monoclonal antibodies

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Evaluation of role of G-CSF in the production, survival, and release of neutrophils from bone marrow into circulation

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BLOOD (2002)

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Innate immune recognition: mechanisms and pathways

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The role of neutrophils in trained immunity

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