期刊
JOURNAL OF IMMUNOLOGY
卷 196, 期 5, 页码 2085-2094出版社
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.1502462
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- University College London Hospitals/University College London National Institute for Health Research Comprehensive Biomedical Research Centre
- National Institute for Health Research Biomedical Research Centre, Oxford
- National Institutes of Health/National Institute of Allergy and Infectious Diseases U19 Bio-Defense Program (National Institutes of Health/National Institute of Allergy and Infectious Diseases) [1U19AI082630-01, U19 AI082630]
- Wellcome Trust Senior Fellowship [WT091663MA]
- Obra Social La Caixa
- Biotechnology and Biological Sciences Research Council [1240827] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0510-10204, NF-SI-0515-10005] Funding Source: researchfish
- Wellcome Trust [109965/Z/15/Z] Funding Source: researchfish
Germinal centers (GCs) are microanatomical structures critical for the development of high-affinity Abs and B cell memory. They are organized into two zones, light and dark, with coordinated roles, controlled by local signaling. The innate lectin-like transcript 1 (LLT1) is known to be expressed on B cells, but its functional role in the GC reaction has not been explored. In this study, we report high expression of LLT1 on GC-associated B cells, early plasmablasts, and GC-derived lymphomas. LLT1 expression was readily induced via BCR, CD40, and CpG stimulation on B cells. Unexpectedly, we found high expression of the LLT1 ligand, CD161, on follicular dendritic cells. Triggering of LLT1 supported B cell activation, CD83 upregulation, and CXCR4 downregulation. Overall, these data suggest that LLT1-CD161 interactions play a novel and important role in B cell maturation within the GC in humans.
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