期刊
IMMUNITY
卷 55, 期 10, 页码 1764-1778出版社
CELL PRESS
DOI: 10.1016/j.immuni.2022.08.008
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资金
- Singapore Ministry of Health's National Medical Research Council under its COVID-19 Research Fund [COVID19RF3-0060, COVID19RF-001, COVID19RF-008]
- Singapore Ministry of Health's National Medical Research Council [MOH-000019, MOH-StaR17- Nov-0001]
This review summarizes the evidence supporting the role of SARS-CoV-2-specific T cells in disease protection and analyzes the different factors that may influence the magnitude, function, and anatomical localization of these T cells, as well as their impact on protecting the host from severe COVID-19 development.
Since the onset of the coronavirus disease 2019 (COVID-19) pandemic, multiple severe acute respiratory syn-drome coronavirus 2 (SARS-CoV-2) variants with increasing ability to evade neutralizing antibodies have emerged. Thus, earlier interest in defining the correlates of protection from infection, mainly mediated by hu-moral immunity, has shifted to correlates of protection from disease, which require a more comprehensive analysis of both humoral and cellular immunity. In this review, we summarized the evidence that supports the role of SARS-CoV-2-specific T cells induced by infection, by vaccination or by their combination (defined as hybrid immunity) in disease protection. We then analyzed the different epidemiological and virological var-iables that can modify the magnitude, function, and anatomical localization of SARS-CoV-2-specific T cells and their influence in the possible ability of T cells to protect the host from severe COVID-19 development.
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