期刊
JOURNAL OF IMMUNOLOGICAL METHODS
卷 434, 期 -, 页码 32-38出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jim.2016.04.004
关键词
Dendritic cells; In vivo depletion models; zDC
资金
- National Institutes of Health (NIH) [AI 13013]
Conventional dendritic cells (cDCs) are essential immune cells linking the innate and adaptive immune system. cDC depletion in mice is an important method to study the function of these cells in vivo. Here we report an inducible in vivo system for cDC depletion in which excision of a loxP flanked Stop signal enables expression of the human diphtheria toxin receptor (DTR) under the control of Zbtb46 (zDC(ISIDTR)). cDCs can be specifically depleted by combining zDC(ISIDTR) mice with a Csf1r(Cre) driver line. In addition, we show that zDC(Cre) mice can be used to produce cDC specific conditional knockout mice (Iris, Irf4, Notch2) which lack specific subsets of cDCs. (C) 2016 Elsevier B.V. All rights reserved.
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