4.3 Review

Cell therapy for type 1 diabetes: from islet transplantation to stem cells

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Article Surgery

Phase 3 trial of human islet-after-kidney transplantation in type 1 diabetes

James F. Markmann et al.

Summary: Allogeneic islet transplant is a safe and effective treatment option for patients with T1D, improving metabolic control and quality of life.

AMERICAN JOURNAL OF TRANSPLANTATION (2021)

Review Surgery

Autoreactive T cell profiles are altered following allogeneic islet transplantation with alemtuzumab induction and re-emerging phenotype is associated with graft function

Shereen Sabbah et al.

Summary: The research indicates that there is no significant difference in the proportion of islet-specific T cell responses in different time periods after islet transplantation, but the types and phenotypes of responses change significantly. An IL-10-dominated response is associated with lower graft function, while an IFN-gamma-dominated response is linked to subsequent C-peptide level decrease.

AMERICAN JOURNAL OF TRANSPLANTATION (2021)

Review Endocrinology & Metabolism

Microencapsulation of cells and molecular therapy of type 1 diabetes mellitus: The actual state and future perspectives between promise and progress

Giuseppe Basta et al.

Summary: The history of microencapsulation of live cells dates back to the 1960s and was applied to pancreatic islet cells in the 1980s. Alginic acid-based polymers have shown superiority over other methods and have entered into clinical trials for diabetic patients. New challenges are being pursued to develop new cellular systems and microencapsulation methods with novel polymeric formulations.

JOURNAL OF DIABETES INVESTIGATION (2021)

Article Endocrinology & Metabolism

Placenta derived Mesenchymal Stem Cells transplantation in Type 1 diabetes: preliminary report of phase 1 clinical trial

Sedighegh Madani et al.

Summary: This preliminary report examines the short-term safety of PLMSCs transplantation in juvenile T1DM, with no serious adverse events observed during the one-year follow-up. However, some patients experienced partial remission and hypoglycemic attacks one month after transplantation. Further investigations are needed to determine the long-term safety and potential efficacy of this treatment.

JOURNAL OF DIABETES AND METABOLIC DISORDERS (2021)

Article Surgery

The demise of islet allotransplantation in the United States: A call for an urgent regulatory update

Piotr Witkowski et al.

Summary: Islet allotransplantation in the United States is facing challenges due to outdated regulatory definitions, hindering patient access and clinical practice. In contrast, other regions globally have more flexible regulations on human islet cells, making islet allotransplantation a standard treatment for selected patients with type 1 diabetes mellitus.

AMERICAN JOURNAL OF TRANSPLANTATION (2021)

Article Cell & Tissue Engineering

Implanted pluripotent stem-cell-derived pancreatic endoderm cells secrete glucose-responsive C-peptide in patients with type 1 diabetes

Adam Ramzy et al.

Summary: This study evaluates the safety and efficacy of implanting pancreatic endoderm cells for treating type 1 diabetes, showing increased C-peptide levels and mature beta cell phenotype in grafts after implantation. The findings provide evidence of meal-regulated insulin secretion by differentiated stem cells in patients.

CELL STEM CELL (2021)

Article Endocrinology & Metabolism

Failure mode and effect analysis in human islet isolation: from the theoretical to the practical risk

Quentin Perrier et al.

Summary: This study assessed the global mapping risk of human islet isolation using FMEA, highlighting the impact of quality assurance procedures on risk level. By implementing reduction measures, critical and severe risks were reduced by 3-fold and 2-fold, respectively, with 90% of risks considered low to moderate.

ISLETS (2021)

Review Endocrinology & Metabolism

In Vivo Imaging of Pancreatic Islet Grafts in Diabetes Treatment

Dian R. Arifin et al.

Summary: Pancreatic islet transplantation has the potential to provide life-long blood glucose management for diabetic patients, with imaging technology playing a crucial role in monitoring and evaluating the success of cell implants in vivo. Various imaging modalities are being developed to improve the precision and efficacy of islet therapy.

FRONTIERS IN ENDOCRINOLOGY (2021)

Article Endocrinology & Metabolism

Patient selection for islet or solid organ pancreas transplantation: experiences from a multidisciplinary outpatient-clinic approach

Espen Nordheim et al.

Summary: Beta-cell replacement therapy, including pancreas transplantation alone and islet transplantation, is a treatment option for selected type 1 diabetes patients in Norway. Evaluation of potential candidates for beta CRT in Norway was initially done by a transplant nephrologist alone, but later shifted to a multidisciplinary team approach. The acceptance rate for beta CRT decreased significantly after the introduction of MDT evaluation, with different outcomes observed between PTA and ITX patients one year post-transplantation.

ENDOCRINE CONNECTIONS (2021)

Article Surgery

Metabolic measures before surgery and long-term diabetes outcomes in recipients of total pancreatectomy and islet autotransplantation

Yoshihide Nanno et al.

Summary: This study demonstrates that metabolic testing measures before surgery can accurately predict insulin independence and glycemic control outcomes after total pancreatectomy with islet autotransplantation, providing valuable prognostic information for patients.

AMERICAN JOURNAL OF TRANSPLANTATION (2021)

Review Cell Biology

Human pluripotent stem cell-derived insulin-producing cells: A regenerative medicine perspective

Adriana Migliorini et al.

Summary: Significant progress has been made in the field of pancreatic beta cell replacement therapy for diabetes over the past two decades. Current challenges include the generation and delivery of stem cell-derived islet-like cells, as well as strategies to induce tolerance for grafted cells to achieve insulin independence for patients.

CELL METABOLISM (2021)

Review Endocrinology & Metabolism

Immunological Monitoring in Beta Cell Replacement: Towards a Pathophysiology-Guided Implementation of Biomarkers

Fanny Buron et al.

Summary: This review discusses the loss of grafted beta cells due to T1D recurrence and allograft rejection, emphasizing the importance of monitoring auto and alloantibodies as biomarkers for T cell activation status. Understanding the pathophysiology is crucial when interpreting biomarkers and selecting appropriate treatments.

CURRENT DIABETES REPORTS (2021)

Review Endocrinology & Metabolism

Effects of islet transplantation on microvascular and macrovascular complications in type 1 diabetes

Laura Reid et al.

Summary: Islet cell transplantation (ICT) is a recommended treatment option for individuals with debilitating hypoglycemia due to type 1 diabetes, aiming to improve glycemic control and reduce severe hypoglycemia. ICT may stabilize or improve microvascular complications, but its impact on macrovascular disease progression and long-term outcomes require further investigation.

DIABETIC MEDICINE (2021)

Article Surgery

Pancreas utilization rates in the UK - an 11-year analysis

Sorina M. Cornateanu et al.

Summary: Utilization of pancreases for transplantation remains lower than other organs, with a significant number of solid pancreases being discarded. Better graft assessment at retrieval could minimize unnecessary organ travel and discards, and closer links with islet programmes may allow for better utilization of discarded grafts.

TRANSPLANT INTERNATIONAL (2021)

Review Engineering, Biomedical

Designing biomaterials for the modulation of allogeneic and autoimmune responses to cellular implants in Type 1 Diabetes

Magdalena M. Samojlik et al.

Summary: Effective suppression of adaptive immune responses is crucial for the success of allogeneic cell therapies, especially in the presence of pre-existing autoimmunity. Current immunosuppressive agents used in islet transplantation show limitations in controlling memory T cell populations, leaving the graft vulnerable. Biomaterials have the potential to provide local and nuanced instruction to suppress immune pathways and improve the efficacy of cell therapy.

ACTA BIOMATERIALIA (2021)

Review Endocrinology & Metabolism

Felix dies natalis, insulin horizontal ellipsis ceterum autem censeo beta is better

Lorenzo Piemonti

Summary: Insulin therapy has been a success story for 100 years, with continuous advancements and breakthroughs in pancreas transplantation and stem cell therapies adding to the options for diabetes treatment.

ACTA DIABETOLOGICA (2021)

Editorial Material Surgery

US food and drug administration (FDA) panel endorses islet cell treatment for type 1 diabetes: A pyrrhic victory?

Lorenzo Piemonti et al.

Summary: Allogeneic islet transplantation is a standard treatment for labile type 1 diabetes in many countries, but commercialization of human tissues and the FDA's licensing regulations pose challenges for universal implementation, leading to exploitation by for-profit entities.

TRANSPLANT INTERNATIONAL (2021)

Review Endocrinology & Metabolism

Non-invasive Beta-cell Imaging: Visualization, Quantification, and Beyond

Takaaki Murakami et al.

Summary: Pancreatic beta-cell dysfunction and reduced mass are central in diabetes, but non-invasive evaluation of beta-cell mass remains elusive. Recent nuclear medical techniques using GLP-1R-targeted imaging probes show promise in evaluating beta-cell mass in diabetes management.

FRONTIERS IN ENDOCRINOLOGY (2021)

Article Medicine, General & Internal

Evaluating the Prognostic Value of Islet Autoantibody Monitoring in Islet Transplant Recipients with Long-Standing Type 1 Diabetes Mellitus

Roi Anteby et al.

Summary: This study evaluated the prognostic utility of monitoring islet autoantibodies in diabetic patients after islet transplantation. It was found that GAD antibody levels could potentially serve as a predictive marker for outcomes post-transplant, while IA-2A and ZnT8A were undetectable in all patients.

JOURNAL OF CLINICAL MEDICINE (2021)

Review Gastroenterology & Hepatology

Efficacy and safety of islet autotransplantation after total pancreatectomy in chronic pancreatitis: A systematic review and meta-analysis including 17 studies

Ya-Jun Zhang et al.

CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY (2020)

Review Surgery

Regenerative medicine, organ bioengineering and transplantation

L. Edgar et al.

BRITISH JOURNAL OF SURGERY (2020)

Review Transplantation

Current status of porcine islet xenotransplantation

Taylor M. Coe et al.

CURRENT OPINION IN ORGAN TRANSPLANTATION (2020)

Article Medicine, General & Internal

Impact of Pancreas Transplantation on the Patient Survival-An Analysis of the Japanese Pancreas Transplants Registry

Taihei Ito et al.

JOURNAL OF CLINICAL MEDICINE (2020)

Article Engineering, Biomedical

Biofabrication of a vascularized islet organ for type 1 diabetes

Antonio Citro et al.

BIOMATERIALS (2019)

Article Endocrinology & Metabolism

Defining outcomes for beta cell replacement therapy: a work in progress

Lorenzo Piemonti et al.

DIABETOLOGIA (2018)

Article Cell & Tissue Engineering

Using Mesenchymal Stromal Cells in Islet Transplantation

Ahmed A. Arzouni et al.

STEM CELLS TRANSLATIONAL MEDICINE (2018)

Review Endocrinology & Metabolism

Will Genetic Engineering Carry Xenotransplantation of Pig Islets to the Clinic?

Elisabeth Kemter et al.

CURRENT DIABETES REPORTS (2018)

Article Pharmacology & Pharmacy

Pluripotent stem cell replacement approaches to treat type 1 diabetes

Silvia Pellegrini et al.

CURRENT OPINION IN PHARMACOLOGY (2018)

Review Biochemistry & Molecular Biology

Rebuilding a better home for transplanted islets

Daniel M. Tremmel et al.

ORGANOGENESIS (2018)

Article Multidisciplinary Sciences

Inactivation of porcine endogenous retrovirus in pigs using CRISPR-Cas9

Dong Niu et al.

SCIENCE (2017)

Review Transplantation

Xenoislets: porcine pancreatic islets for the treatment of type I diabetes

Nizar I. Mourad et al.

CURRENT OPINION IN ORGAN TRANSPLANTATION (2017)

Review Endocrinology & Metabolism

Immunological Issues After Stem Cell-Based β Cell Replacement

Valeria Sordi et al.

CURRENT DIABETES REPORTS (2017)

Review Endocrinology & Metabolism

Porcine Islet Xenografts: a Clinical Source of β-Cell Grafts

Bassem F. Salama et al.

CURRENT DIABETES REPORTS (2017)

Article Endocrinology & Metabolism

Phase 3 Trial of Transplantation of Human Islets in Type 1 Diabetes Complicated by Severe Hypoglycemia

Bernhard J. Hering et al.

DIABETES CARE (2016)

Article Medicine, General & Internal

Clinical Benefit of Islet Xenotransplantation for the Treatment of Type 1 Diabetes

Shinichi Matsumoto et al.

EBIOMEDICINE (2016)

Article Surgery

The UK Pancreas Allocation Scheme for Whole Organ and Islet Transplantation

A. Hudson et al.

AMERICAN JOURNAL OF TRANSPLANTATION (2015)

Article Biochemistry & Molecular Biology

Controlled induction of human pancreatic progenitors produces functional beta-like cells in vitro

Holger A. Russ et al.

EMBO JOURNAL (2015)

Article Multidisciplinary Sciences

Genome-wide inactivation of porcine endogenous retroviruses (PERVs)

Luhan Yang et al.

SCIENCE (2015)

Article Endocrinology & Metabolism

Preserved β-Cell Function in Type 1 Diabetes by Mesenchymal Stromal Cells

Per-Ola Carlsson et al.

DIABETES (2015)

Article Cell & Tissue Engineering

Setting Up a Haplobank: Issues and Solutions

Jacqueline Barry et al.

CURRENT STEM CELL REPORTS (2015)

Article Biochemistry & Molecular Biology

Generation of Functional Human Pancreatic β Cells In Vitro

Felicia W. Pagliuca et al.

Article Endocrinology & Metabolism

Autologous Islet Transplantation in Patients Requiring Pancreatectomy for Neoplasm

Gianpaolo Balzano et al.

CURRENT DIABETES REPORTS (2014)

Editorial Material Endocrinology & Metabolism

Improvement of Electrophysiological Neuropathy After Islet Transplantation for Type 1 Diabetes: A 5-Year Prospective Study

Marie-Christine Vantyghem et al.

DIABETES CARE (2014)

Article Biotechnology & Applied Microbiology

Reversal of diabetes with insulin-producing cells derived in vitro from human pluripotent stem cells

Alireza Rezania et al.

NATURE BIOTECHNOLOGY (2014)

Article Multidisciplinary Sciences

Differentiated human stem cells resemble fetal, not adult, β cells

Sinisa Hrvatin et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Article Endocrinology & Metabolism

Improvement in Outcomes of Clinical Islet Transplantation: 1999-2010

Franca B. Barton et al.

DIABETES CARE (2012)

Article Surgery

Total Pancreatectomy and Islet Autotransplantation for Chronic Pancreatitis

David E. R. Sutherland et al.

JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS (2012)

Article Gastroenterology & Hepatology

Quality of Life Improves for Pediatric Patients After Total Pancreatectomy and Islet Autotransplant for Chronic Pancreatitis

Melena D. Bellin et al.

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2011)

Article Endocrinology & Metabolism

Alternative Transplantation Sites for Pancreatic Islet Grafts

Elisa Cantarelli et al.

CURRENT DIABETES REPORTS (2011)

Article Biotechnology & Applied Microbiology

Cell-surface markers for the isolation of pancreatic cell types derived from human embryonic stem cells

Olivia G. Kelly et al.

NATURE BIOTECHNOLOGY (2011)

Article Immunology

Long-term follow-up of patients with type 1 diabetes transplanted with neonatal pig islets

R. Valdes-Gonzalez et al.

CLINICAL AND EXPERIMENTAL IMMUNOLOGY (2010)

Article Endocrinology & Metabolism

Pediatric Islet Autotransplantation: Indication, Technique, and Outcome

Melena D. Bellin et al.

CURRENT DIABETES REPORTS (2010)

Article Endocrinology & Metabolism

Quality of life after islet transplantation: data from the GRAGIL 1 and 2 trials

P. Y. Benhamou et al.

DIABETIC MEDICINE (2009)

Article Endocrinology & Metabolism

Restoration of Hypoglycemia Awareness After Islet Transplantation

Cristiane B. Leitao et al.

DIABETES CARE (2008)

Article Biochemistry & Molecular Biology

Generation of Insulin-secreting Islet-like Clusters from Human Skin Fibroblasts

Keisuke Tateishi et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2008)

Editorial Material Immunology

Improved Long-Term Health-Related Quality of Life After Islet Transplantation

Thipaporn Tharavanij et al.

TRANSPLANTATION (2008)

Article Surgery

High risk of sensitization after failed islet transplantation

P. M. Campbell et al.

AMERICAN JOURNAL OF TRANSPLANTATION (2007)

Article Medicine, Research & Experimental

Live encapsulated porcine islets from a type 1 diabetic patient 9.5 yr after xenotransplantation

Robert B. Elliott et al.

XENOTRANSPLANTATION (2007)

Article Surgery

Changes in renal function after clinical islet transplantation: Four-year observational study

P. A. Senior et al.

AMERICAN JOURNAL OF TRANSPLANTATION (2007)

Article Biotechnology & Applied Microbiology

Production of pancreatic hormone-expressing endocrine cells from human embryonic stem cells

Kevin A. D'Amour et al.

NATURE BIOTECHNOLOGY (2006)

Article Surgery

Quality of life after islet transplantation

R Poggioli et al.

AMERICAN JOURNAL OF TRANSPLANTATION (2006)

Article Endocrinology & Metabolism

Xenotransplantation of porcine neonatal islets of Langerhans and Sertoli cells:: a 4-year study

RA Valdés-González et al.

EUROPEAN JOURNAL OF ENDOCRINOLOGY (2005)

Article Endocrinology & Metabolism

beta-cell function following human islet transplantation for type 1 diabetes

MR Rickels et al.

DIABETES (2005)

Letter Endocrinology & Metabolism

Reduced fear of hypoglycemia in successful islet transplantation

JA Johnson et al.

DIABETES CARE (2004)

Article Surgery

Mortality assessment for pancreas transplants

RWG Gruessner et al.

AMERICAN JOURNAL OF TRANSPLANTATION (2004)

Article Medicine, General & Internal

Survival after pancreas transplantation in patients with diabetes and preserved kidney function

JM Venstrom et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2003)