Helicobacter pylori and cardiovascular risk: Only a dead Helicobacter is a good Helicobacter?

Review Cardiac & Cardiovascular Systems

Helicobacter pylori Infection Is Associated With Carotid Intima and Media Thickening: A Systematic Review and Meta-Analysis

Orsolya Anna Simon et al.

Summary: This study found an association between H. pylori infection and increased carotid intima-media thickness through a systematic review and meta-analysis.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

Transgenically expressed Helicobacter pylori CagA in vascular endothelial cells accelerates arteriosclerosis in mice

Kamrunnesa Tahmina et al.

Summary: Arteriosclerosis is closely related to cardiovascular diseases. Infection with Helicobacter pylori cagA-positive strains is involved in the development of arteriosclerosis. CagA is delivered into endothelial cells and activates inflammatory responses, accelerating the progression of arteriosclerosis/atherosclerosis.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2022)

添加到收藏夹

Article Medicine, General & Internal

Evaluating the relationship between Helicobacter pylori infection and carotid intima-media thickness a cross sectional study

Hamid Reza Talari et al.

Summary: This study found that there is a significant increase in carotid intima-media thickness in patients infected with CagA-positive Helicobacter pylori, along with significantly elevated levels of the inflammatory marker hsCRP. Therefore, H. pylori infection, especially with CagA-positive strains, and its associated systemic inflammatory response may contribute to the development of atherosclerosis and cardiovascular disease.

ANNALS OF MEDICINE AND SURGERY (2021)

添加到收藏夹

Review Medicine, General & Internal

Association between helicobacter pylori infection and subclinical atherosclerosis A systematic review and meta-analysis

Xianghong Wang et al.

Summary: This meta-analysis confirmed a significant association between H. pylori infection and subclinical atherosclerosis, indicating a strong correlation with clinical significance. Sensitivity analyses showed robust results, and no significant publication bias was detected.

MEDICINE (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Inhibition of low-density lipoprotein uptake by Helicobacter pylori virulence factor CagA

Ryo Ninomiya et al.

Summary: Infection with H. pylori can lead to gastroduodenal diseases, while CagA-positive strains may contribute to hypercholesterolemia and atherosclerotic cardiovascular diseases. Research has shown that CagA inhibits LDL uptake mediated by LDLR, which in turn may increase plasma LDL levels and accelerate atherosclerosis.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2021)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

SCORE2 risk prediction algorithms: new models to estimate 10-year risk of cardiovascular disease in Europe

Steven Hageman et al.

Summary: The study aimed to develop, validate, and demonstrate an updated prediction model (SCORE2) to estimate 10-year cardiovascular disease risk in individuals without previous history of CVD or diabetes in Europe. The new algorithm, SCORE2, enhances the identification of individuals at higher risk of developing CVD across Europe by predicting first-onset CVD risk in European populations.

EUROPEAN HEART JOURNAL (2021)

添加到收藏夹

Article Multidisciplinary Sciences

A sex-specific propensity-adjusted analysis of colonic adenoma detection rates in a screening cohort

Sarah Wernly et al.

Summary: The study found that the prevalence of any adenoma and advanced adenoma is lower in females compared to males, even after propensity score adjustment for baseline characteristics and lifestyle factors, and in age-adjusted sensitivity analyses across different age groups.

SCIENTIFIC REPORTS (2021)

添加到收藏夹

Article Medicine, General & Internal