期刊
CANCER TREATMENT REVIEWS
卷 41, 期 6, 页码 547-553出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.ctrv.2015.04.009
关键词
Breast cancer; Androgen receptor; Estrogen receptor; Triple negative
类别
Triple negative breast cancer (TNBC) is an aggressive breast cancer subtype. The absence of expression and/or amplification of estrogen and progesterone receptor as well as ERBB-2 prevent the use of currently available endocrine options and/or ERBB-2-directed drugs and indicates chemotherapy as the main current therapy. TNBC represents approximately 15% of breast cancer cases with high index of heterogeneity. Here, we review the role of androgen receptor in breast carcinogenesis and its association with alterations in the expression pattern and functional roles of regulatory molecules and signal transduction pathways in TNBC. Additionally, based on the so far preclinical and clinical published data, we evaluate the perspectives for using and/or developing androgen receptor targeting strategies for specific TNBC subtypes. (C) 2015 Elsevier Ltd. All rights reserved.
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