4.7 Article

Scalable and model-free detection of spatial patterns and colocalization

期刊

GENOME RESEARCH
卷 32, 期 9, 页码 1736-1745

出版社

COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gr.276851.122

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资金

  1. National Cancer Institute [U2C CA233291, U54 CA217450]
  2. National Institutes of Health [P01 AI139449]
  3. Cancer Center Support Grant [P30CA068485]

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The rapid growth of spatial omics technologies enables the profiling of genome-wide molecular events at molecular and single-cell resolution. SpaGene, a model-free method, is developed to discover spatial patterns rapidly in large-scale spatial omics studies. It outperforms existing methods in power and scalability, and is able to reconstruct unobserved tissue structures and discover ligand-receptor interactions through colocalization.
The expeditious growth in spatial omics technologies enables the profiling of genome-wide molecular events at molecular and single-cell resolution, highlighting a need for fast and reliable methods to characterize spatial patterns. We developed SpaGene, a model-free method to discover spatial patterns rapidly in large-scale spatial omics studies. Analyzing simulation and a variety of spatially resolved transcriptomics data showed that SpaGene is more powerful and scalable than existing methods. Spatial expression patterns identified by SpaGene reconstruct unobserved tissue structures. SpaGene also successfully discovers ligand-receptor interactions through their colocalization.

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