KDM3A promotes oral squamous cell carcinoma cell proliferation and invasion via H3K9me2 demethylation-activated DCLK1

Article Biology

The histone demthylase KDM3A protects the myocardium from ischemia/reperfusion injury via promotion of ETS1 expression

Xin Guo et al.

Summary: The study shows that KDM3A plays a crucial role in myocardial ischemia/reperfusion injury by activating the ETS1 gene. Boosting KDM3A expression could be a potential treatment strategy for this condition.

COMMUNICATIONS BIOLOGY (2022)

添加到收藏夹

Review Oncology

Crucial Functions of the JMJD1/KDM3 Epigenetic Regulators in Cancer

Yuan Sui et al.

Summary: Epigenetic changes in cancer development often involve dysregulation of enzymes modifying DNA or histones, with JMJD1 proteins playing a key role as histone lysine demethylases. The JMJD1 subfamily, including JMJD1A, JMJD1B, and JMJD1C, have been shown to have significant impact on tumorigenesis through regulation of gene expression and oncogene activation. While JMJD1A and JMJD1C are often overexpressed in tumors and promote cancer growth, JMJD1B may exhibit tumor suppressive functions in certain cancers.

MOLECULAR CANCER RESEARCH (2021)

添加到收藏夹

Article Oncology

Effect of Hypoxia on Proliferation and the Expression of the Genes HIF-1α and JMJD1A in Head and Neck Squamous Cell Carcinoma Cell Lines

Christian Wilhelm et al.

Summary: The study investigated the effects of hypoxia on proliferation and the expression of HIF-1 alpha and JMJDIA in head and neck squamous cell carcinoma. The results confirmed that HIF-1 alpha and JMJDIA are relevant hypoxia-dependent regulators of carcinogenesis in HNSCC.

ANTICANCER RESEARCH (2021)

添加到收藏夹

Article Cell Biology

Extracellular vesicles-encapsulated let-7i shed from bone mesenchymal stem cells suppress lung cancer via KDM3A/DCLK1/FXYD3 axis

Jiefeng Liu et al.

Summary: The study revealed that BMSC-EV-derived let-7i exerts an inhibitory role in lung cancer progression through the KDM3A/DCLK1/FXYD3 axis.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2021)

添加到收藏夹

Article Cell Biology

Tumor-Suppressive Role of microRNA-202-3p in Hepatocellular Carcinoma Through the KDM3A/HOXA1/MEIS3 Pathway

Yijie Zhang et al.

Summary: This study identified a novel miR-202-3p/KDM3A/HOXA1/MEIS3 pathway in HCC, where miR-202-3p negatively regulated KDM3A, leading to increased expression of HOXA1 and MEIS3, and reduced viability, migration, and invasion of HCC cells. Upregulation of miR-202-3p also inhibited the growth of human HCC cells in vivo, suggesting a potential therapeutic target for HCC.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

添加到收藏夹

Article Oncology

Overview of oral cavity squamous cell carcinoma: Risk factors, mechanisms, and diagnostics

Ambika Chamoli et al.

Summary: Oral cavity squamous cell carcinoma is the most common malignancy in the oral cavity, with risk factors such as tobacco and alcohol consumption. Late diagnosis leads to decreased survival rates. Understanding the genetic alterations and molecular mechanisms involved is crucial for developing targeted treatments for oral cavity cancer.

ORAL ONCOLOGY (2021)

添加到收藏夹

Article Pharmacology & Pharmacy

XMD-17-51 Inhibits DCLK1 Kinase and Prevents Lung Cancer Progression

Wei-Qiang Yang et al.

Summary: XMD-17-51 has been found to inhibit DCLK1 kinase activity in non-small cell lung carcinoma cells, leading to reduced cell proliferation, EMT, and stemness marker expression. This compound shows potential as a candidate drug for lung cancer therapy.

FRONTIERS IN PHARMACOLOGY (2021)

添加到收藏夹

Review Oncology

DCLK1 and its interaction partners: An effective therapeutic target for colorectal cancer

Muthu Vijai et al.

Summary: DCLK1 is a microtubule-associated protein with roles in early neurogenesis and the gastrointestinal tract, as well as implications in various types of cancer. Its underlying molecular mechanisms remain unclear, but potential therapeutic strategies targeting cancer cells are being explored through understanding its interactions with similar proteins.

ONCOLOGY LETTERS (2021)

添加到收藏夹

Article Medicine, Research & Experimental

KDM1A and KDM3A promote tumor growth by upregulating cell cycle-associated genes in pancreatic cancer

Xuyang Hou et al.

Summary: This study found that KDM1A and KDM3A are highly expressed in pancreatic cancer and are associated with clinicopathological features and prognosis, being involved in tumor growth by regulating cell cycle-associated genes.

EXPERIMENTAL BIOLOGY AND MEDICINE (2021)

添加到收藏夹

Review Gastroenterology & Hepatology

Histone methylation in pancreatic cancer and its clinical implications

Xing-Yu Liu et al.

Summary: In pancreatic cancer research, histone methylation plays a crucial role, with writers and erasers potentially serving as therapeutic targets, while further research on reader domains is needed.

WORLD JOURNAL OF GASTROENTEROLOGY (2021)

添加到收藏夹

Article Oncology

Doublecortin-Like Kinase 1 (DCLK1) Is a Novel NOTCH Pathway Signaling Regulator in Head and Neck Squamous Cell Carcinoma

Esther C. Broner et al.

Summary: Despite recent advancements, the 5-year survival rate of head and neck squamous cell carcinoma (HNSCC) remains at 60%. DCLK1 has been found to regulate epithelial-to-mesenchymal transition and serve as a cancer stem cell marker in various cancers. This study demonstrated that DCLK1 expression positively correlates with activation of the NOTCH signaling pathway in HNSCC, and inhibition of DCLK1 resulted in decreased cell proliferation, invasion, migration, and colony formation. Additionally, high DCLK1 expression was associated with poor prognosis in HNSCC.

FRONTIERS IN ONCOLOGY (2021)

添加到收藏夹

Review Oncology