期刊
CANCER TREATMENT REVIEWS
卷 41, 期 5, 页码 391-400出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.ctrv.2015.03.008
关键词
Ewing sarcoma; Targeted therapies
类别
资金
- NCATS Grant (Center for Clinical and Translational Sciences) [UL1 TR000371]
- MD Anderson Cancer Center Support Grant [P30 CA016672]
The prognosis of adolescent and young adult patients battling metastatic Ewing sarcoma family of tumors (ESFT) remains less than 30% despite the development of systemic therapies. In the era of personalized medicine, novel molecular targets have been tested in preclinical or clinical settings in ESFT. In this review, we focus on early clinical and translational research that identified multiple molecular targets, including IGF-1R; mTOR; tyrosine kinase inhibitors; EWS-FLI1-related targets, and others. Overall, novel targeted therapies demonstrated modest efficacy; however pronounced and durable antineoplastic responses have been observed in small subsets of treated patients, for example with IGF-1R antibodies. Identifying outcome-predicting biomarkers and overcoming treatment resistance remain major challenges. Due to the rarity of ESFT, multi-institutional collaboration efforts of clinicians, basic and translational scientists are needed in order to understand biology of therapeutic response or resistance, which can lead to development of novel therapeutic methods and improved patient outcomes. (C) 2015 Elsevier Ltd. All rights reserved.
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