4.6 Article

Insulin can up-regulate LC-PUFA biosynthesis with the involvement of Srebp-1c and stimulatory protein 1 (Sp1) in marine teleost Siganus canaliculatus

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Summary: This article reviews progress on LC-PUFA biosynthesis in teleosts, focusing on the identified Fads and Elovl, as well as the regulatory mechanisms at transcriptional and post-transcriptional levels. Insights into improving endogenous LC-PUFA biosynthesis capacity to reduce dependence on fish oil while maintaining or increasing flesh LC-PUFA content and the nutritional quality of farmed fish are provided.

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