期刊
FOOD CHEMISTRY
卷 388, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.foodchem.2022.133034
关键词
Food fermentation; Dipeptides; Biogenic amines; Anti-hypertension; Natto; Derivatization
资金
- Science and Technology Develop-ment Fund, Macau SAR [FDCT 0025/2021/A1]
This study found that natto has a higher ACE inhibitory effect than soybean and identified 246 amino acid compounds, with 187 of them only detected in natto. Dipeptides with ACE inhibitory abilities were the most abundant class and positively correlated with the increased ACE inhibitory activity of natto. Dynamic profiling revealed that the increased dipeptides in natto were generated from protein via Bacillus subtilis natto fermentation.
Food fermentation has been playing an important role in producing bioactive components (e.g., peptides), which exert many healthy effects. In this study, it was observed that natto possessed significantly higher angiotensin Iconverting enzyme (ACE) inhibitory effect than soybean. Meanwhile, a total of 246 amino-containing compounds were identified via LC-Q-TOF-MS/MS, including amino acids, dipeptides, tripeptides, O-methyl-peptide, and biogenic amines, 187 of them were only detected in natto. Of the list, dipeptides, with ACE inhibitory abilities or potentials, were found to be the most significantly up-regulated class and positively correlated with significantly increased ACE inhibitory activity of natto. Moreover, dynamic profiling elucidated the increased dipeptides were generated from water soluble and insoluble protein via Bacillus subtilis natto fermentation. Taken together, this study enriches the chemical diversity of natto and provides an in-depth insight into the degradation mechanism of soy protein during natto fermentation, which can be extended to other functional foods.
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