期刊
FOOD CHEMISTRY
卷 405, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.foodchem.2022.134736
关键词
Piper nigrum; Alkaloid; Anti-inflammatory; Chemosensitizer
This research investigated the bioactive alkaloids of the stems of Piper nigrum and found eight new dimeric amide alkaloids and eight known compounds. All compounds showed excellent anti-inflammatory activity, and the dimeric amide alkaloids enhanced the anticancer effect of paclitaxel against cervical cancer cells. These results highlight the potential of P. nigrum stems as a sustainable source of bioactive alkaloids for development and utilization in the food and health industries.
Piper nigrum is an important aromatic plant, and its fruits (black and white pepper) are commonly used as food additives and spices. However, its stems were disposed as wastes. This research comprehensively investigated bioactive alkaloids of the stems, eight new dimeric amide alkaloids and eight known compounds were obtained. All obtained compounds showed excellent anti-inflammatory activity. Additionally, the dimeric amide alkaloids enhanced the anticancer effect of paclitaxel against cervical cancer cells. These results demonstrate that the stems of P. nigrum could be the sustainable source of bioactive alkaloids for development and utilization in the food and health fields.
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