☆ 4.6 Review

Dysregulation of cellular membrane homeostasis as a crucial modulator of cancer risk

FEBS JOURNAL (2022)

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Article Chemistry, Physical

The Two Faces of the Liquid Ordered Phase

Itay Schachter et al.

Summary: Through atomistic molecular dynamics simulations, differential scanning calorimetry, and fluorescence spectroscopy on L-o phase membranes, it was found that a stiff, hexagonally packed lipid structure in the L-o phase at room temperature excludes raft-associated proteins, but upon heating, this structure melts, leading to preferential solvation of proteins by order-preferring lipids.

JOURNAL OF PHYSICAL CHEMISTRY LETTERS (2022)

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Article Biochemistry & Molecular Biology

PD-L1 interacts with Frizzled 6 to activate β-catenin and form a positive feedback loop to promote cancer stem cell expansion

Lingchen Fu et al.

Summary: PD-L1 interacts with Frizzled 6 receptor to activate beta-catenin signaling and increase the expression of stem cell markers, thereby maintaining and expanding the population of cancer stem cells. Blocking PD-L1 function can inhibit tumor progression by reducing the CSC population.

ONCOGENE (2022)

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Review Immunology

The cholesterol pathway: impact on immunity and cancer

Ryan J. King et al.

Summary: Cholesterol plays a role in cancer, atherosclerosis, and autoimmunity by modulating the immune system. Manipulating cholesterol metabolism may improve immunotherapy responses in cancer treatment. It can have both proinflammatory and anti-inflammatory effects in mammals, acting through various immune cell types depending on the context. Understanding the mechanisms of cholesterol-related metabolites can enhance our knowledge of their functions and effects on the immune system, leading to the development of better therapeutic strategies.

TRENDS IN IMMUNOLOGY (2022)

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Article Biochemistry & Molecular Biology

Reduced ER-mitochondria connectivity promotes neuroblastoma multidrug resistance

Jorida Coku et al.

Summary: Most cancer deaths occur due to the progression of therapy resistant disease, however, our understanding of this phenotype is limited. Cancer therapies generate stress signals that trigger cell apoptosis. Our study showed that resistance to therapy is associated with reduced Bak and Bax oligomerization and cytochrome c release in tumor cells. We also found that reducing ER-mitochondria-associated membranes (MAMs) in therapy-sensitive tumors can mimic resistance. MAMs serve as platforms for transferring Ca2+ and bioactive lipids to mitochondria. In addition, we discovered that reduced ceramide synthesis and transfer in resistant cells is common and its inhibition induces stress resistance.

EMBO JOURNAL (2022)

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Review Multidisciplinary Sciences

The changing epidemiology of SARS-CoV-2

Katia Koelle et al.

Summary: This review retraces the steps taken by the global community of epidemiologists and evolutionary biologists in understanding and controlling the COVID-19 pandemic. It highlights the crucial roles that mathematical modeling and quantitative analyses of empirical data have played in addressing the challenges faced by this community.

SCIENCE (2022)

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Review Genetics & Heredity

Phospholipid Scramblases: Role in Cancer Progression and Anticancer Therapeutics

Himadri Gourav Behuria et al.

Summary: This article provides a comprehensive analysis of the role of phospholipid scramblases (PLSCRs) in tumor cells and how metastatic tumor cells escape the clearance of apoptotic cells through altering membrane features and surface exposure of phosphatidyl serine (PS). It also discusses the potential therapeutic implications of targeting PLSCRs and PS exposure as novel drug targets.

FRONTIERS IN GENETICS (2022)

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Review Cell Biology

Nuclear lipid droplets - how are they different from their cytoplasmic siblings?

Toyoshi Fujimoto

Summary: Lipid droplets in the cytoplasm are formed in the endoplasmic reticulum and are connected with various organelles. Nuclear lipid droplets in hepatocytes are derived from lipoprotein precursors in the ER lumen, while in non-hepatocytes and budding yeast, they are newly formed in the inner nuclear membrane. Although nuclear lipid droplets are fewer in number, their unique location suggests specific functions related to nuclear biology.

JOURNAL OF CELL SCIENCE (2022)

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Article Chemistry, Multidisciplinary

A Role for Lipids in Protein Sorting?

Auxiliadora Aguilera-Romero et al.

Summary: The diversity of lipids and proteins provides structural and functional identity to membrane compartments of eukaryotic cells, with the secretory pathway maintaining compositional heterogeneity. While proteins are known to play a key role in sorting mechanisms, the contribution of lipids in this process is still under discussion. Recent interdisciplinary research has highlighted the role of lipid diversity and protein-lipid interactions in sorting processes at the cell membrane.

CHIMIA (2021)

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Review Chemistry, Multidisciplinary

Pharmaceutical strategies for endoplasmic reticulum-targeting and their prospects of application

Yingying Shi et al.

Summary: Modern drug delivery systems leverage accurate delivery routes to enhance drug efficacy and reduce toxicity. The endoplasmic reticulum, a versatile subcellular organelle, plays a crucial role in cell survival and maintenance of homeostasis. Recent research focuses on direct and indirect targeting of the endoplasmic reticulum to deepen understanding of its biology and facilitate precise intracellular regulation.

JOURNAL OF CONTROLLED RELEASE (2021)

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Article Chemistry, Multidisciplinary

Targeted Solvatochromic Fluorescent Probes for Imaging Lipid Order in Organelles under Oxidative and Mechanical Stress

Dmytro Danylchuk et al.

Summary: A series of solvatochromic probes have been designed for specific targeting of different organelles in live cells, allowing the detection of variations in lipid order and quantitative description of lipid order in each organelle. These probes revealed the characteristics of organelles under stress conditions, with mitochondria and lysosomes particularly sensitive to stress. The new probes provide a powerful toolbox for monitoring cellular response to physical and chemical stimuli at the level of individual organelle membranes.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2021)

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Article Cell Biology

Targeting Phosphatidylserine Enhances the Anti-tumor Response to Tumor-Directed Radiation Therapy in a Preclinical Model of Melanoma

Sadna Budhu et al.

Summary: The study showed that targeting PS with antibodies can enhance the efficacy of tumor-directed RT and improve overall survival, while also increasing proinflammatory tumor-associated macrophages. Combining PD-1 blockade with RT further increases anti-tumor efficacy and survival, particularly in patients with metastatic melanoma.

CELL REPORTS (2021)

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Review Cell Biology

Regulation of Wnt Signaling Pathways at the Plasma Membrane and Their Misregulation in Cancer

Yagmur Azbazdar et al.

Summary: Wnt signaling pathway plays a crucial role in physiological activities and has significant implications in cancer development and progression. By regulating plasma membrane composition and lipid organization, Wnt signaling can be activated or inhibited, leading to the development of more targeted anticancer drugs.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Article Chemistry, Multidisciplinary

Fluorescent Membrane Tension Probes for Early Endosomes

Francesca Piazzolla et al.

Summary: Researchers have developed a rational strategy to target early endosomes using a substituted benzylamine with a higher pKa value as the head group of flipper probes. This allows for preserved mechanosensitivity and can be used to elucidate the mechanics of endocytosis in biology.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

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Review Cell Biology

Wnt/β-catenin signaling: Structure, assembly and endocytosis of the signalosome

Gabriele Colozza et al.

Summary: The Wnt/β-catenin signaling pathway regulates key aspects of development and stem cell homeostasis through endocytosis, and also influences metabolic pathways. Despite unclear regulatory mechanisms, this pathway displays diverse characteristics beyond gene expression regulation.

DEVELOPMENT GROWTH & DIFFERENTIATION (2021)

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Review Neurosciences

Advances in the study of organelle interactions and their role in neurodegenerative diseases enabled by super-resolution microscopy

Meng Lu et al.

Summary: The development of modern neuroscience has greatly benefited from breakthroughs in imaging technology, particularly in the study of neurodegenerative diseases. Progress in the field has been closely linked to the development of super-resolution imaging methods, which have advanced our understanding of disease mechanisms such as protein aggregates and organelle defects. Recent studies have implicated the disruption of inter-organelle interactions in multiple neurodegenerative diseases.

NEUROBIOLOGY OF DISEASE (2021)

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Review Urology & Nephrology

PD-1 immunobiology in glomerulonephritis and renal cell carcinoma

Colleen S. Curran et al.

Summary: The expression and function of PD-1 and its ligands in the kidney play a crucial role in maintaining immunological homeostasis. Dysregulated PD-1:PD-L1 binding interactions are associated with glomerulopathies and renal cell carcinoma. Understanding the regulation of PD-1 axis by various signals and factors is important for kidney disease and PD-1 immunotherapy.

BMC NEPHROLOGY (2021)

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Article Biochemistry & Molecular Biology

ApoE4 (Δ272-299) induces mitochondrial-associated membrane formation and mitochondrial impairment by enhancing GRP75-modulated mitochondrial calcium overload in neuron

Tao Liang et al.

Summary: Neuronal expression of apoE4 (Delta 272-299) induces mitochondrial impairment through ER stress and MAM formation, as well as promoting GRP75 expression and mitochondrial calcium overload. These effects can be significantly mitigated by treatment with ER stress inhibitor, GRP75 inhibitor, or GRP75 silencing.

CELL AND BIOSCIENCE (2021)

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Article Cell Biology

High-throughput multiparametric imaging flow cytometry: toward diffraction-limited sub-cellular detection and monitoring of sub-cellular processes

Gregor Holzner et al.

Summary: This sheathless, microfluidic imaging flow cytometer with stroboscopic illumination achieves blur-free fluorescence detection at ultra-high analytical throughput, quantifying multi-parametric fluorescence and sub-cellular localization at 500 nm resolution. The effectiveness of the approach is demonstrated through analysis and localization of P-bodies and stress granules in yeast and human cells, with throughputs exceeding 60,000 and 400,000 cells/s. The utility of the imaging flow cytometer is highlighted in directly investigating phase-separated compartments within cellular environments and screening rare events at the sub-cellular level for various diagnostic applications.

CELL REPORTS (2021)

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Review Immunology

Plasma Membrane Integrates Biophysical and Biochemical Regulation to Trigger Immune Receptor Functions

Tongtong Zhang et al.

Summary: The plasma membrane serves as a critical platform for immune cells to initiate signaling cascades and immune responses against pathogens or tumor cells. The biophysical-chemical properties of the plasma membrane may cooperatively regulate immune receptor functions, impacting their structural conformation, distribution, and organization to influence signal transduction.

FRONTIERS IN IMMUNOLOGY (2021)

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Review Cell Biology

Endoplasmic Reticulum-Plasma Membrane Contact Sites: Regulators, Mechanisms, and Physiological Functions

Chenlu Li et al.

Summary: Endoplasmic reticulum (ER) forms direct membrane contact sites with the plasma membrane (PM) in eukaryotic cells, playing crucial roles in lipid homeostasis, ion dynamics, and cell signaling through protein-protein or protein-lipid interactions. Distinct tethering factors dynamically regulate the architecture of ER-PM junctions in response to signals, and the physiological roles of these contact sites rely on various regulators acting in diverse cellular processes. This review focuses on proteins at ER-PM contact sites, highlighting recent progress in their mechanisms and physiological roles.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Review Cell Biology

Targeting Lipid Rafts as a Strategy Against Coronavirus

Maurizio Sorice et al.

Summary: Lipid rafts play a crucial role in coronavirus entry, with drugs targeting lipid rafts components potentially reducing viral infectivity.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Review Biochemistry & Molecular Biology

Membrane lipids and transporter function

Bruno Stieger et al.

Summary: Transport proteins play a crucial role in the exchange of substances between cells and their environment, and they are affected by the specific binding and bulk modulation of membrane lipids. Human diseases that disrupt lipid homeostasis can alter membrane lipid composition and consequently impact the function of transporter proteins.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2021)

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Article Biology

Patched 1 reduces the accessibility of cholesterol in the outer leaflet of membranes

Maia Kinnebrew et al.

Summary: The study reveals that PTCH1 inhibits the activity of Smoothened by depleting accessible cholesterol from the outer leaflet of the plasma membrane, potentially involving an exchange of potassium ions. This finding establishes a general framework for investigating how proteins change cholesterol accessibility to regulate membrane-dependent processes in cells.

ELIFE (2021)

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Review Biology

Plasma membrane integrity: implications for health and disease

Dustin A. Ammendolia et al.

Summary: Plasma membrane integrity is crucial for cellular homeostasis, and cells have repair pathways to restore membrane integrity when damaged. Tissue-specific stressors and membrane repair pathways play important roles in health and disease. Genetic and environmental factors impact plasma membrane integrity and contribute to disease pathogenesis in various tissues.

BMC BIOLOGY (2021)

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Article Oncology

The Role of Plasma Membrane Viscosity in the Response and Resistance of Cancer Cells to Oxaliplatin

Liubov Shimolina et al.

Summary: Understanding the role of plasma membrane in cancer cell response to chemotherapy, especially platinum drugs like oxaliplatin, is crucial for developing new therapeutic approaches. Changes in membrane viscosity and lipid composition induced by oxaliplatin were identified, showing that maintaining a constant membrane viscosity through lipid remodeling is essential for drug resistance in cancer.

CANCERS (2021)

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Article Medicine, Research & Experimental

Lysophospholipid acylation modulates plasma membrane lipid organization and insulin sensitivity in skeletal muscle

Patrick J. Ferrara et al.

Summary: Obesity accelerates the skeletal muscle Lands cycle, leading to disruption of plasma membrane organization and suppression of muscle insulin action.

JOURNAL OF CLINICAL INVESTIGATION (2021)

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Review Biochemistry & Molecular Biology

Lipid Profiles of RAS Nanoclusters Regulate RAS Function

Yong Zhou et al.

Summary: This review article discusses the selective lipid composition within RAS nanoclusters on the plasma membrane, the impact of different lipids on RAS signaling and oncogenesis, and how perturbing lipid compositions within RAS nanoclusters affects RAS function and pathology. Different strategies of manipulating lipid composition within RAS nanoclusters on the plasma membrane are also described.

BIOMOLECULES (2021)

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Article Medicine, Research & Experimental

Loss of ephrin B2 receptor (EPHB2) sets lipid rheostat by regulating proteins DGAT1 and ATGL inducing lipid droplet storage in prostate cancer cells

Alejandro Morales et al.

Summary: The study reveals that EPHB2 deficiency in prostate cancer cells results in abnormal accumulation of lipid droplets and increased cell proliferation, mainly by regulating the key proteins DGAT1 and ATGL involved in lipid metabolism.

LABORATORY INVESTIGATION (2021)

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Review Biochemistry & Molecular Biology

Paradigm shift: the primary function of the Adiponectin Receptors is to regulate cell membrane composition

Marc Pilon

Summary: ADIPORs are now considered as evolutionarily conserved regulators that do not require adiponectin to act as membrane fluidity sensors. They are activated by membrane rigidification to promote fatty acid desaturation and incorporation of polyunsaturated fatty acids into membrane phospholipids until fluidity is restored.

LIPIDS IN HEALTH AND DISEASE (2021)

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Article Oncology

Lipid raft-disrupting miltefosine preferentially induces the death of colorectal cancer stem-like cells

So-Yeon Park et al.

Summary: This study highlights the important role of lipid rafts (LRs) in colorectal cancer, where an LR-disrupting alkylphospholipid drug can suppress CSC populations and their self-renewal activities. By inhibiting the LR/CHEK1 axis, the drug forces CSCs to enter inappropriate mitosis, leading to catastrophic cell death.

CLINICAL AND TRANSLATIONAL MEDICINE (2021)

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Article Biotechnology & Applied Microbiology

Targeting cholesterol biosynthesis promotes anti-tumor immunity by inhibiting long noncoding RNA SNHG29-mediated YAP activation

Wen Ni et al.

Summary: Research has shown that simvastatin inhibits PD-L1 expression and promotes anti-tumor immunity by suppressing the expression of lncRNA SNHG29. SNHG29 interacts with YAP and inhibits its degradation, leading to the downregulation of PD-L1.

MOLECULAR THERAPY (2021)

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Review Biochemistry & Molecular Biology

Misregulation of Wnt Signaling Pathways at the Plasma Membrane in Brain and Metabolic Diseases

Mustafa Karabicici et al.

Summary: Wnt signaling pathways are essential for various physiological and pathological processes, including neurodegenerative diseases and metabolic disorders. Changes in plasma membrane composition and organization play a crucial role in activating these pathways, offering potential for targeted therapy development for brain and metabolic diseases.

MEMBRANES (2021)

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Article Multidisciplinary Sciences

Single-cell lipidomics with high structural specificity by mass spectrometry

Zishuai Li et al.

Summary: Single-cell lipidomic analysis is crucial for classification of human cells based on lipid structure and position, which can promote the development of precision medicine.

NATURE COMMUNICATIONS (2021)

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Article Multidisciplinary Sciences

Quantitative imaging of membrane contact sites for sterol transfer between endo-lysosomes and mitochondria in living cells

Alice Dupont Juhl et al.

Summary: The study reveals the crucial role of NPC2 protein in cholesterol transport from endo-lysosomes to mitochondria, facilitating the interaction between these organelles as a defining feature of membrane contact sites (MCSs) that plays a key role in sterol transport.

SCIENTIFIC REPORTS (2021)

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Review Cell Biology

Role of Cholesterol and Lipid Rafts in Cancer Signaling: A Promising Therapeutic Opportunity?

Rosa Vona et al.

Summary: Cholesterol is crucial for cell membrane structure and plays a key role in regulating cell signaling pathways. Its homeostasis is tightly regulated and dysregulation may be linked to cardiovascular diseases and cancer development.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Article Biology

β-catenin-promoted cholesterol metabolism protects against cellular senescence in naked mole-rat cells

Woei-Yaw Chee et al.

Summary: The study explores the unique mechanisms of cholesterol metabolism in naked mole-rat cells, which may contribute to their anti-senescent properties and longevity. Beta-catenin is identified as a key player in regulating cholesterol metabolism to offset senescence in naked mole-rats.

COMMUNICATIONS BIOLOGY (2021)

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Article Cell Biology

Peroxidation of n-3 and n-6 polyunsaturated fatty acids in the acidic tumor environment leads to ferroptosis-mediated anticancer effects

Emeline Dierge et al.

Summary: Excess uptake of specific polyunsaturated fatty acids can selectively induce ferroptosis in cancer cells under acidic conditions, potentially serving as an adjuvant antitumor modality to complement pharmacological approaches.

CELL METABOLISM (2021)

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Article Biochemistry & Molecular Biology

Torsin and NEP1R1-CTDNEP1 phosphatase affect interphase nuclear pore complex insertion by lipid-dependent and lipid-independent mechanisms

Julie Jacquemyn et al.

Summary: Torsin affects lipid metabolism by regulating NEP1R1-CTDNEP1 and Lipin, influencing nuclear envelope remodeling and nuclear pore complex biogenesis. This mechanism explains some of the pleiotropic effects of Torsins.

EMBO JOURNAL (2021)

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Article Cell Biology

EGFR-RAS-MAPK signaling is confined to the plasma membrane and associated endorecycling protrusions

Sachin Surve et al.

Summary: The study demonstrated that endogenous KRAS and NRAS are predominantly localized to the plasma membrane and do not colocalize with endosomal EGFR upon EGF stimulation. It was suggested that a small pool of surface EGFRs sustain signaling within the RAS-ERK1/2 pathway.

JOURNAL OF CELL BIOLOGY (2021)

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Article Biochemistry & Molecular Biology

Mutant APC promotes tumor immune evasion via PD-L1 in colorectal cancer

Bo Cen et al.

Summary: Mutations in the APC gene lead to resistance of colonic epithelial cells to CD8(+) T cell cytotoxicity by inducing PD-L1 expression. This is mediated by the beta-catenin/TCF4 complex binding to the PD-L1 promoter, resulting in increased transcription. These findings suggest a potential new approach for immune checkpoint inhibition by targeting beta-catenin or TCF4.

ONCOGENE (2021)

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Review Biochemistry & Molecular Biology

Mitochondrial compartmentalization: emerging themes in structure and function

Joseph C. Iovine et al.

Summary: Compartmentalization within cellular structures refers to the spatial segregation of macromolecules, metabolites, and biochemical pathways, bridging organellar structure and function. Mitochondria, with their morphological complexity and dynamic polymorphism, undergo morphogenesis events that must be considered both spatially and temporally. Disturbance in mitochondrial compartmentalization can lead to dysfunction associated with heritable and aging-related diseases.

TRENDS IN BIOCHEMICAL SCIENCES (2021)

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Review Biotechnology & Applied Microbiology

Cholesterol Metabolism as a Potential Therapeutic Target and a Prognostic Biomarker for Cancer Immunotherapy

Huixian Zhang et al.

Summary: Cholesterol metabolism has been linked to tumor development and could offer a new breakthrough in immunotherapy. This study highlights how cholesterol metabolism impacts immune cell function within tumors and suggests that cholesterol levels could serve as a biomarker for predicting the efficacy of immunotherapy.

ONCOTARGETS AND THERAPY (2021)

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Article Multidisciplinary Sciences

PD-L1 degradation is regulated by electrostatic membrane association of its cytoplasmic domain

Maorong Wen et al.

Summary: The cytoplasmic domain of PD-L1 (PD-L1-CD) is involved in regulating PD-L1 stability and degradation. Here the authors show that membrane binding of PD-L1-CD mediates the cellular levels of PD-L1, while metformin can disrupt the interaction between PD-L1-CD and the membrane to reduce PD-L1 levels.

NATURE COMMUNICATIONS (2021)

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Review Oncology

WNT as a Driver and Dependency in Cancer

Marie J. Parsons et al.

Summary: The WNT signaling pathway plays a critical role in various cancer types, with distinct patterns of dysregulation and immune evasion mechanisms. Targeting the oncogenic effects of WNT signaling is a current focus of research in developing therapeutic strategies for cancer treatment.

CANCER DISCOVERY (2021)

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Review Nutrition & Dietetics

Beneficial Outcomes of Omega-6 and Omega-3 Polyunsaturated Fatty Acids on Human Health: An Update for 2021

Ivana Djuricic et al.

Summary: Oxidative stress and inflammation are important contributors to chronic non-communicable diseases. Different types of fatty acids have varying effects on chronic diseases, with moderate intake of Ω-6 fatty acids lowering the risk of cardiovascular diseases and Ω-3 fatty acids helping to reduce inflammation levels.

NUTRIENTS (2021)

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Article Cell Biology

p53-intact cancers escape tumor suppression through loss of long noncoding RNA Dino

Christina B. Marney et al.

Summary: This study identified a lncRNA called DINO, which is frequently silenced in human cancers, impairing the p53 signaling pathway and reducing tumor suppression. DINO and TP53 together constitute a common tumor suppressor module.

CELL REPORTS (2021)

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Article Biology

Quantitative live-cell imaging and computational modeling shed new light on endogenous WNT/CTNNB1 signaling dynamics

Saskia M. A. de Man et al.

Summary: WNT/CTNNB1 signaling regulates tissue development and homeostasis in multicellular animals by affecting the dynamic distribution of CTNNB1 through regulatory nodes including the destruction complex, nucleocytoplasmic shuttling, and nuclear retention, as revealed by an integrated experimental and computational approach. The study found that a substantial fraction of CTNNB1 resides in slow-diffusing cytoplasmic complexes, which undergo a major reduction in size when the pathway is hyperactivated. The research provides quantitative insight into endogenous protein behavior and sheds light on the molecular mechanism underlying WNT/CTNNB1 signaling.

ELIFE (2021)

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Article Cell Biology

Statins Decrease Programmed Death-Ligand 1 (PD-L1) by Inhibiting AKT and β-Catenin Signaling

Woo-Jin Lim et al.

Summary: Studies have shown that statins can reduce PD-L1 expression in cancer cells by inhibiting the AKT and beta-catenin signaling pathways, providing compelling evidence for the clinical evaluation of combining statins with immune checkpoint inhibitors for cancer therapy.

CELLS (2021)

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Review Cell Biology

Role of ERLINs in the Control of Cell Fate through Lipid Rafts

Valeria Manganelli et al.

Summary: ERLINs are a family of proteins involved in ER-associated protein degradation and regulation of lipid metabolism. They have been traditionally considered markers of ER lipid raft-like microdomains but have also been found in mitochondria-associated endoplasmic reticulum membranes (MAMs) under pathophysiological conditions, influencing cell fate by regulating processes such as survival and death. Their alteration can significantly impact the pathogenesis of various human diseases.

CELLS (2021)

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Article Cell Biology

Receptor/Raft Ratio Is a Determinant for LRP6 Phosphorylation and WNT/β-Catenin Signaling

Fiete Haack et al.

Summary: Microdomains or lipid rafts significantly impact protein and peptide distribution in the membrane, with LRP6 being crucially localized in lipid rafts for successful phosphorylation and activation. A significant portion of the cell plasma membrane is covered by nanoscopic raft domains, indicating potential effects on signaling pathways.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Review Biochemistry & Molecular Biology

Blocking K-Ras Interaction With the Plasma Membrane Is a Tractable Therapeutic Approach to Inhibit Oncogenic K-Ras Activity

Karen M. Henkels et al.

Summary: Ras proteins play a key role in cell proliferation, differentiation, and apoptosis, and activating mutations are common in cancer cases. Among the three isoforms, oncogenic mutations in K-Ras are predominant in Ras-driven cancers. Blocking K-Ras binding to the plasma membrane is a promising strategy for developing anti-K-Ras therapies.

FRONTIERS IN MOLECULAR BIOSCIENCES (2021)

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Article Biophysics

Long-term STED imaging of membrane packing and dynamics by exchangeable polarity-sensitive dyes

Pablo Carravilla et al.

Summary: Understanding the nanoscale organization and dynamics of plasma membrane in living cells requires microscopy techniques with high spatial and temporal resolution. The polarity-sensitive exchangeable plasma membrane probe NR4A based on Nile red allows real-time super-resolved quantification of membrane biophysical parameters with high temporal and spatial resolution, as well as long acquisition times.

BIOPHYSICAL REPORTS (2021)

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Article Cell Biology

PD-L1 recruits phospholipase C and enhances tumorigenicity of lung tumors harboring mutant forms of EGFR

Soma Ghosh et al.

Summary: The research indicates that tumors with EGFR mutations have a lower response to immunotherapy, the EGFR pathway is associated with high PD-L1 expression and can promote an aggressive phenotype, while anti-PD-L1 antibodies can inhibit PD-L1 functions.

CELL REPORTS (2021)

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Article Biochemistry & Molecular Biology

Membrane therapy using DHA suppresses epidermal growth factor receptor signaling by disrupting nanocluster formation

Natividad R. Fuentes et al.

Summary: The study identified that docosahexaenoic acid (DHA) reduces EGFR signaling by reshaping EGFR proteolipid nanodomains, suggesting the potential of using membrane therapy to target plasma membrane organization and reduce cancer risk.

JOURNAL OF LIPID RESEARCH (2021)

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Article Plant Sciences

Geometry and cellular function of organelle membrane interfaces

Abel Rosado et al.

Summary: Biological membranes play a crucial role in cellular processes by providing a platform for concentrating signaling and metabolic components. The diverse shapes of membranes and their 3D architecture at contact sites define cellular activity. Changes in membrane contact site architecture can rapidly respond to cellular perturbations and confer functional specificity to cellular territories.

PLANT PHYSIOLOGY (2021)

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Review Nutrition & Dietetics

Role of n-3 long-chain polyunsaturated fatty acids in human nutrition and health: review of recent studies and recommendations

Peter Van Dael

Summary: This paper provides an overview of the metabolism, sources, dietary recommendations, and effects of long-chain n-3 polyunsaturated fatty acids (n-3 PUFAs) in cardiovascular diseases, neurodegenerative disorders, depression, and premature birth risk. Expert recommendations suggest a daily intake of 500 mg of DHA and EPA for cardiovascular health, 200-300 mg/day for depression, and 600-800 mg/day of DHA during pregnancy to reduce premature birth risk.

NUTRITION RESEARCH AND PRACTICE (2021)

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Article Biochemistry & Molecular Biology

Cathepsin L plays a key role in SARS-CoV-2 infection in humans and humanized mice and is a promising target for new drug development

Miao-Miao Zhao et al.

Summary: CTSL plays a crucial role in COVID-19 patients, with its levels positively correlated with disease severity. Research showed that CTSL promotes SARS-CoV-2 virus entry into cells, and the CTSL inhibitor amantadine can inhibit this process, providing a direction for the development of new anti-COVID-19 drugs.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

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Review Pharmacology & Pharmacy

Wnt Signaling and Drug Resistance in Cancer

Zheng Zhong et al.

MOLECULAR PHARMACOLOGY (2020)

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Article Biophysics

The Plasma Membrane as a Competitive Inhibitor and Positive Allosteric Modulator of KRas4B Signaling

Chris Neale et al.

BIOPHYSICAL JOURNAL (2020)

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Article Oncology

High-resolution imaging mass spectrometry combined with transcriptomic analysis identified a link between fatty acid composition of phosphatidylinositols and the immune checkpoint pathway at the primary tumour site of breast cancer

Masahiro Kawashima et al.

BRITISH JOURNAL OF CANCER (2020)

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Review Biochemistry & Molecular Biology

Lipid rafts as signaling hubs in cancer cell survival/death and invasion: implications in tumor progression and therapy

Faustino Mollinedo et al.

JOURNAL OF LIPID RESEARCH (2020)

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Article Plant Sciences

The Nanoscale Organization of the Plasma Membrane and Its Importance in Signaling: A Proteolipid Perspective(1)([OPEN])

Yvon Jaillais et al.

PLANT PHYSIOLOGY (2020)

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Review Cell Biology

Lipid Rafts: Controversies Resolved, Mysteries Remain

Ilya Levental et al.

TRENDS IN CELL BIOLOGY (2020)

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Review Biochemistry & Molecular Biology

Lipid homeostasis in mitochondria

Yasushi Tamura et al.

BIOLOGICAL CHEMISTRY (2020)

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Review Oncology

Dietary Approaches to Cancer Therapy

Mylene Tajan et al.

CANCER CELL (2020)

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Review Oncology

The Frequency of Ras Mutations in Cancer

Ian A. Prior et al.

CANCER RESEARCH (2020)

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β-Catenin induces transcriptional expression of PD-L1 to promote glioblastoma immune evasion

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AdipoR1 and AdipoR2 maintain membrane fluidity in most human cell types and independently of adiponectin

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The Multifunctional Sorting Protein PACS-2 Controls Mitophagosome Formation in Human Vascular Smooth Muscle Cells through Mitochondria-ER Contact Sites

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Switchable Solvatochromic Probes for Live-Cell Super-resolution Imaging of Plasma Membrane Organization

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Antidiabetic adiponectin receptor agonist AdipoRon suppresses tumour growth of pancreatic cancer by inducing RIPK1/ERK-dependent necroptosis

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Microfluidic-spinning construction of black-phosphorus-hybrid microfibres for non-woven fabrics toward a high energy density flexible supercapacitor

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High-resolution imaging and quantification of plasma membrane cholesterol by NanoSIMS

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Systems biology of cellular membranes: a convergence with biophysics

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Rapalogs can promote cancer cell stemness in vitro in a Galectin-1 and H-ras-dependent manner

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Epidermal Growth Factor Receptor Cell Proliferation Signaling Pathways

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Reversible Nuclear-Lipid-Droplet Morphology Induced by Oleic Acid: A Link to Cellular-Lipid Metabolism

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Cholesterol Enhances Colorectal Cancer Progression via ROS Elevation and MAPK Signaling Pathway Activation

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CURRENT OPINION IN LIPIDOLOGY (2017)

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Single-molecule fluorescence microscopy review: shedding new light on old problems

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Emerging role of chemoprotective agents plasma membrane organization

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BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2017)

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Membrane lipid alterations in the metabolic syndrome and the role of dietary oils

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BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2017)

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Super-Resolution Microscopy: Shedding Light on the Cellular Plasma Membrane

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Hypercholesterolemia Increases Colorectal Cancer Incidence by Reducing Production of NKT and γδ T Cells from Hematopoietic Stem Cells

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Solvatochromic and Fluorogenic Dyes as Environment-Sensitive Probes: Design and Biological Applications

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Lipid-Sorting Specificity Encoded in K-Ras Membrane Anchor Regulates Signal Output

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Interleaf let Coupling, Pinning, and Leaflet Asymmetry-Major Players in Plasma Membrane Nanodomain Formation

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CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION (2016)

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GPI-anchored protein organization and dynamics at the cell surface

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Inhibition of Acid Sphingomyelinase Depletes Cellular Phosphatidylserine and Mislocalizes K-Ras from the Plasma Membrane

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Testing Molecular Homogeneity at the Nanoscale with Massive Cluster Secondary Ion Mass Spectrometry

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Interdigitation of long-chain sphingomyelin induces coupling of membrane leaflets in a cholesterol dependent manner

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BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2016)

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Review Biochemistry & Molecular Biology

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BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2016)

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The Secreted Signaling Protein Wnt3 Is Associated with Membrane Domains In Vivo: A SPIM-FCS Study

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Polyunsaturated Lipids Regulate Membrane Domain Stability by Tuning Membrane Order

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Glycosylation-Dependent IFN-γR Partitioning in Lipid and Actin Nanodomains Is Critical for JAK Activation

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Canonical Wnt/β-Catenin Signaling Pathway Is Dysregulated in Patients With Primary and Secondary Myelofibrosis

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CLINICAL LYMPHOMA MYELOMA & LEUKEMIA (2016)

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EUROPEAN JOURNAL OF PHARMACOLOGY (2016)

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Prolonged Intake of Dietary Lipids Alters Membrane Structure and T Cell Responses in LDLr-/- Mice

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JOURNAL OF IMMUNOLOGY (2016)

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LIPIDS IN HEALTH AND DISEASE (2016)

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MOLECULAR CELL (2016)

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

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Stromal Hedgehog signalling is downregulated in colon cancer and its restoration restrains tumour growth

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ONCOTARGET (2016)

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Caenorhabditis elegans PAQR-2 and IGLR-2 Protect against Glucose Toxicity by Modulating Membrane Lipid Composition

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Changes in membrane sphingolipid composition modulate dynamics and adhesion of integrin nanoclusters

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SCIENTIFIC REPORTS (2016)

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Time-of-Flight Secondary Ion Mass Spectrometry (ToF-SIMS): A New Tool for the Analysis of Toxicological Effects on Single Cell Level

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Label-Free Raman Spectroscopic Imaging Monitors the Integral Physiologically Relevant Drug Responses in Cancer Cells

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Cardiolipin is a key determinant for mtDNA stability and segregation during mitochondrial stress

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Mechanisms of localized activation of the T cell antigen receptor inside clusters

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Fluorescence Lifetime Imaging of Membrane Lipid Order with a Ratiometric Fluorescent Probe

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Lipid bilayers: clusters, domains and phases

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MEMBRANE NANODOMAINS (2015)

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Sialidase NEU3 contributes neoplastic potential on colon cancer cells as a key modulator of gangliosides by regulating Wnt signaling

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Membrane Interactions of Phytochemicals as Their Molecular Mechanism Applicable to the Discovery of Drug Leads from Plants

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Yap-dependent reprogramming of Lgr5+ stem cells drives intestinal regeneration and cancer

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Gain-of-function p53 mutants co-opt chromatin pathways to drive cancer growth

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HIV gp41-mediated membrane fusion occurs at edges of cholesterol-rich lipid domains

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OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2015)

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Cholesterol uptake disruption, in association with chemotherapy, is a promising combined metabolic therapy for pancreatic adenocarcinoma

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

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Ras-GTP dimers activate the Mitogen-Activated Protein Kinase (MAPK) pathway

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

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Membrane lipid therapy: Modulation of the cell membrane composition and structure as a molecular base for drug discovery and new disease treatment

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The interactions between mitochondria and sarcoplasmic reticulum and the proteome characterization of mitochondrion-associated membrane from rabbit skeletal muscle

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Membrane potential modulates plasma membrane phospholipid dynamics and K-Ras signaling

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Interactions of flavan-3-ols and procyanidins with membranes: mechanisms and the physiological relevance

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Specific cancer-associated mutations in the switch III region of Ras increase tumorigenicity by nanocluster augmentation

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Single Particle Tracking Reveals that EGFR Signaling Activity Is Amplified in Clathrin-Coated Pits

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Oncotarget (2015)

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Phosphatidic Acid (PA) can Displace PARα/LXRα Binding to The EGFR Promoter Causing its Transrepression in Luminal Cancer Cells

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SCIENTIFIC REPORTS (2015)

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Omega-3 fatty acids for breast cancer prevention and survivorship

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Phytochemicals Perturb Membranes and Promiscuously Alter Protein Function

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ACS CHEMICAL BIOLOGY (2014)

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Rafting through traffic: Membrane domains in cellular logistics

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BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2014)

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Lo/Ld phase coexistence modulation induced by GM1

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BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2014)

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Review Biochemistry & Molecular Biology

The Fluid-Mosaic Model of Membrane Structure: Still relevant to understanding the structure, function and dynamics of biological membranes after more than 40 years

Garth L. Nicolson

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2014)

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Review Biochemistry & Molecular Biology

Regulation of the cancer cell membrane lipid composition by NaCHOleate Effects on cell signaling and therapeutical relevance in glioma

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BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2014)

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Imaging lipids with secondary ion mass spectrometry

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BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2014)

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Review Biochemistry & Molecular Biology

MAM (mitochondria-associated membranes) in mammalian cells: Lipids and beyond

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BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2014)

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Article Immunology

Lipid raft-based membrane order is important for antigen-specific clonal expansion of CD4+ T lymphocytes

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BMC IMMUNOLOGY (2014)

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Serum Lipid Profile and Risk of Prostate Cancer Recurrence: Results from the SEARCH Database

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CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION (2014)

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Omega-3 Fatty Acid Is a Potential Preventive Agent for Recurrent Colon Cancer

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CANCER PREVENTION RESEARCH (2014)

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Regulation of EGFR nanocluster formation by ionic protein-lipid interaction

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CELL RESEARCH (2014)

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Exploiting APC Function as a Novel Cancer Therapy

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CURRENT DRUG TARGETS (2014)

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Spatial control of phospholipid flux restricts endoplasmic reticulum sheet formation to allow nuclear envelope breakdown

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GENES & DEVELOPMENT (2014)

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GENES & DEVELOPMENT (2014)

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Phosphatidylserine-Targeted Molecular Imaging of Tumor Vasculature by Magnetic Resonance Imaging

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JOURNAL OF BIOMEDICAL NANOTECHNOLOGY (2014)

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Bridging the gap: Membrane contact sites in signaling, metabolism, and organelle dynamics

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JOURNAL OF CELL BIOLOGY (2014)

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Nanoclustering as a dominant feature of plasma membrane organization

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JOURNAL OF CELL SCIENCE (2014)

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Article Oncology

Statin Use After Colorectal Cancer Diagnosis and Survival: A Population-Based Cohort Study

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JOURNAL OF CLINICAL ONCOLOGY (2014)

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Review Oncology

The multiple facets of drug resistance: one history, different approaches

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JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2014)

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Article Biochemistry & Molecular Biology

Signal Integration by Lipid-Mediated Spatial Cross Talk between Ras Nanoclusters

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MOLECULAR AND CELLULAR BIOLOGY (2014)

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Measuring Lipid Packing of Model and Cellular Membranes with Environment Sensitive Probes

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LANGMUIR (2014)

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Metabolic control of YAP and TAZ by the mevalonate pathway

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NATURE CELL BIOLOGY (2014)

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Insights into the initiation of TCR signaling

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NATURE IMMUNOLOGY (2014)

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Statin Use and Breast Cancer Survival: A Nationwide Cohort Study from Finland

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PLOS ONE (2014)

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Article Multidisciplinary Sciences

Membrane raft association is a determinant of plasma membrane localization

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

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Article Multidisciplinary Sciences

Molecular architecture of the αβ T cell receptor-CD3 complex

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

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Tolerance and exhaustion: defining mechanisms of T cell dysfunction

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TRENDS IN IMMUNOLOGY (2014)

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Mitochondrial protein sorting as a therapeutic target for ATP synthase disorders

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NATURE COMMUNICATIONS (2014)

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Cholesterol selectively activates canonical Wnt signalling over non-canonical Wnt signalling

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NATURE COMMUNICATIONS (2014)

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Extracellular activation of Wnt signaling through epigenetic dysregulation of Wnt inhibitory factor-1 (Wif-1) is associated with pathogenesis of adrenocortical tumor

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ONCOTARGET (2014)

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Article Cell Biology

Phospholipids that Contain Polyunsaturated Fatty Acids Enhance Neuronal Cell Mechanics and Touch Sensation

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CELL REPORTS (2014)

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Global analysis of p53-regulated transcription identifies its direct targets and unexpected regulatory mechanisms

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ELIFE (2014)

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Three pools of plasma membrane cholesterol and their relation to cholesterol homeostasis

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ELIFE (2014)

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Membrane microdomains: from seeing to understanding

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FRONTIERS IN PLANT SCIENCE (2014)

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Article Oncology

Mechanisms by Which Pleiotropic Amphiphilic n-3 PUFA Reduce Colon Cancer Risk

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CURRENT COLORECTAL CANCER REPORTS (2014)

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Review Pharmacology & Pharmacy

Biophysics of cell membrane lipids in cancer drug resistance: Implications for drug transport and drug delivery with nanoparticles

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ADVANCED DRUG DELIVERY REVIEWS (2013)

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Article Biochemistry & Molecular Biology

Procyanidins can interact with Caco-2 cell membrane lipid rafts: Involvement of cholesterol

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BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2013)

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Review Biochemistry & Molecular Biology

Phospholipid metabolism and nuclear function: Roles of the lipin family of phosphatidic acid phosphatases

Symeon Siniossoglou

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2013)

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Review Biochemistry & Molecular Biology

Where the endoplasmic reticulum and the mitochondrion tie the knot: The mitochondria-associated membrane (MAM)

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BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2013)

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Review Biochemistry & Molecular Biology

Cholesterol accumulation in prostate cancer: A classic observation from a modern perspective

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BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2013)

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Article Oncology

Prolonged Biologically Active Colonic Tissue Levels of Curcumin Achieved After Oral Administration-A Clinical Pilot Study Including Assessment of Patient Acceptability

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CANCER PREVENTION RESEARCH (2013)

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New Perspectives of Curcumin in Cancer Prevention

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CANCER PREVENTION RESEARCH (2013)

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Article Cell Biology

Tam41 Is a CDP-Diacylglycerol Synthase Required for Cardiolipin Biosynthesis in Mitochondria

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CELL METABOLISM (2013)

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Article Cell Biology

Lypd6 Enhances Wnt/β-Catenin Signaling by Promoting Lrp6 Phosphorylation in Raft Plasma Membrane Domains

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DEVELOPMENTAL CELL (2013)

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Review Biochemistry & Molecular Biology

On the future of mass-spectrometry-based lipidomics

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FEBS JOURNAL (2013)

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A Single Peptide-Major Histocompatibility Complex Ligand Triggers Digital Cytokine Secretion in CD4+ T Cells

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IMMUNITY (2013)

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Bioavailability of Intact Proanthocyanidins in the Rat Colon after Ingestion of Grape Seed Extract

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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2013)

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Article Biochemistry & Molecular Biology

Bile Acids Modulate Signaling by Functional Perturbation of Plasma Membrane Domains

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JOURNAL OF BIOLOGICAL CHEMISTRY (2013)

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Article Cell Biology

Insulin receptor activation through its accumulation in lipid rafts by mild electrical stress

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JOURNAL OF CELLULAR PHYSIOLOGY (2013)

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Type I and II Endometrial Cancers: Have They Different Risk Factors?

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JOURNAL OF CLINICAL ONCOLOGY (2013)

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A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity

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NATURE (2013)

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Editorial Material Genetics & Heredity

The Cancer Genome Atlas Pan-Cancer analysis project

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NATURE GENETICS (2013)

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Article Immunology

Conformational states of the kinase Lck regulate clustering in early T cell signaling

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NATURE IMMUNOLOGY (2013)

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Distinct TCR signaling pathways drive proliferation and cytokine production in T cells

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NATURE IMMUNOLOGY (2013)

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Review Cell Biology

The mechanisms of Hedgehog signalling and its roles in development and disease

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NATURE REVIEWS MOLECULAR CELL BIOLOGY (2013)

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Characterization of a New Series of Fluorescent Probes for Imaging Membrane Order

Joanna M. Kwiatek et al.

PLOS ONE (2013)

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Article Multidisciplinary Sciences

Diet-Induced Obesity Promotes Colon Tumor Development in Azoxymethane-Treated Mice

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PLOS ONE (2013)

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Article Multidisciplinary Sciences

Overexpression of YAP and TAZ Is an Independent Predictor of Prognosis in Colorectal Cancer and Related to the Proliferation and Metastasis of Colon Cancer Cells

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PLOS ONE (2013)

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Membrane Elastic Properties and Cell Function

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PLOS ONE (2013)

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Direct chemical evidence for sphingolipid domains in the plasma membranes of fibroblasts

Jessica F. Frisz et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

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Review Biochemistry & Molecular Biology

Lipids of mitochondria

Susanne E. Horvath et al.

PROGRESS IN LIPID RESEARCH (2013)

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Nelson P. Barrera et al.

TRENDS IN CELL BIOLOGY (2013)

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Lipid Transport between the Endoplasmic Reticulum and Mitochondria

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COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2013)

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COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2013)

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PAQR-2 Regulates Fatty Acid Desaturation during Cold Adaptation in C. elegans

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PLOS GENETICS (2013)

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Article Biochemistry & Molecular Biology

Actin-dependent clustering of insulin receptors in membrane microdomains

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BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2012)

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Article Biochemistry & Molecular Biology

Adiponectin deficiency: Role in chronic inflammation induced colon cancer

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BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2012)

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Review Biochemistry & Molecular Biology

Regulators of mammalian Hippo pathway in cancer

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Mutant p53 Disrupts Mammary Tissue Architecture via the Mevalonate Pathway

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YAP oncogene overexpression supercharges colon cancer proliferation

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Omega-3 polyunsaturated fatty acids for the treatment and prevention of colorectal cancer

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Lipin-1 Phosphatidic Phosphatase Activity Modulates Phosphatidate Levels to Promote Peroxisome Proliferator-activated Receptor γ (PPAR γ) Gene Expression during Adipogenesis

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Programmed cell death 1 forms negative costimulatory microclusters that directly inhibit T cell receptor signaling by recruiting phosphatase SHP2

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A novel biotinylated lipid raft reporter for electron microscopic imaging of plasma membrane microdomains

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Bidirectional Ion Emission from Massive Gold Cluster Impacts on Nanometric Carbon Foils

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Proteomic Consequences of a Single Gene Mutation in a Colorectal Cancer Model

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Quantitative imaging of membrane lipid order in cells and organisms

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Christof Niehrs

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Statin Use and Reduced Cancer-Related Mortality

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NEW ENGLAND JOURNAL OF MEDICINE (2012)

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Diet and Nutrient Factors in Colorectal Cancer Risk

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Overexpressed Galectin-3 in Pancreatic Cancer Induces Cell Proliferation and Invasion by Binding Ras and Activating Ras Signaling

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Organization, dynamics, and segregation of Ras nanoclusters in membrane domains

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

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Organized living: formation mechanisms and functions of plasma membrane domains in yeast

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ER stress activates the NLRP3 inflammasome via an UPR-independent pathway

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Omega-3 Fatty Acids EPA and DHA: Health Benefits Throughout Life

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Anticancer Activity of the Cholesterol Exporter ABCA1 Gene

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The nuclear envelope proteome differs notably between tissues

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NUCLEUS (2012)

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Review Immunology

TCR signaling emerges from the sum of many parts

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FRONTIERS IN IMMUNOLOGY (2012)

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Review Nutrition & Dietetics

Health Implications of High Dietary Omega-6 Polyunsaturated Fatty Acids

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JOURNAL OF NUTRITION AND METABOLISM (2012)

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Analysis of Native Biological Surfaces Using a 100 kV Massive Gold Cluster Source

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ANALYTICAL CHEMISTRY (2011)

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Gli Proteins in Development and Disease

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ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 27 (2011)

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Phase IIa Clinical Trial of Curcumin for the Prevention of Colorectal Neoplasia

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CANCER PREVENTION RESEARCH (2011)

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Novel Theranostic Opportunities Offered by Characterization of Altered Membrane Lipid Metabolism in Breast Cancer Progression

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CANCER RESEARCH (2011)

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Long-term Use of Cholesterol-Lowering Drugs and Cancer Incidence in a Large United States Cohort

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Signaling from the Living Plasma Membrane

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CELL (2011)

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Signaling clusters in the cell membrane

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CURRENT OPINION IN CELL BIOLOGY (2011)

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Article Gastroenterology & Hepatology

Loss of Adiponectin Promotes Intestinal Carcinogenesis in Min and Wild-type Mice

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Functional Nanoscale Organization of Signaling Molecules Downstream of the T Cell Antigen Receptor

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IMMUNITY (2011)

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Curcumin enhances dasatinib-induced inhibition of growth and transformation of colon cancer cells

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INTERNATIONAL JOURNAL OF CANCER (2011)

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Characterization and quantification of nanoparticle-antibody conjugates on cells using C60 ToF SIMS in the event-by-event bombardment/detection mode

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Making heads or tails of phospholipids in mitochondria

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JOURNAL OF CELL BIOLOGY (2011)

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Article Cell Biology

Lipid Raft Localization of EGFR Alters the Response of Cancer Cells to the EGFR Tyrosine Kinase Inhibitor Gefitinib

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JOURNAL OF CELLULAR PHYSIOLOGY (2011)

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Total Cholesterol and Cancer Risk in a Large Prospective Study in Korea

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JOURNAL OF CLINICAL ONCOLOGY (2011)

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Primary Human CD4+ T Cells Have Diverse Levels of Membrane Lipid Order That Correlate with Their Function

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JOURNAL OF IMMUNOLOGY (2011)

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Review Biochemistry & Molecular Biology

Early steps in steroidogenesis: intracellular cholesterol trafficking

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JOURNAL OF LIPID RESEARCH (2011)

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Review Biochemical Research Methods

Physico-mechanical characterisation of cells using atomic force microscopy - Current research and methodologies

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JOURNAL OF MICROBIOLOGICAL METHODS (2011)

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Article Chemistry, Multidisciplinary

Super-resolution Microscopy of Lipid Bilayer Phases

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JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2011)

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Article Cell Biology

Confinement of β1- and β2-adrenergic receptors in the plasma membrane of cardiomyocyte-like H9c2 cells is mediated by selective interactions with PDZ domain and A-kinase anchoring proteins but not caveolae

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MOLECULAR BIOLOGY OF THE CELL (2011)

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Article Medicine, General & Internal

National, regional, and global trends in serum total cholesterol since 1980: systematic analysis of health examination surveys and epidemiological studies with 321 country-years and 3.0 million participants

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Article Medicine, General & Internal

National, regional, and global trends in body-mass index since 1980: systematic analysis of health examination surveys and epidemiological studies with 960 country-years and 9.1 million participants

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Article Biochemistry & Molecular Biology

Incorporation of EPA and DHA into plasma phospholipids in response to different omega-3 fatty acid formulations - a comparative bioavailability study of fish oil vs. krill oil

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LIPIDS IN HEALTH AND DISEASE (2011)

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Pre-existing clusters of the adaptor Lat do not participate in early T cell signaling events

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NATURE IMMUNOLOGY (2011)

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Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin

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NATURE MEDICINE (2011)

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Raft domains of variable properties and compositions in plasma membrane vesicles

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

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Editorial Material Gastroenterology & Hepatology

Multifaceted nature of membrane microdomains in colorectal cancer

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WORLD JOURNAL OF GASTROENTEROLOGY (2011)

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Phase Separation in Lipid Membranes

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COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2011)

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Cell-type-specific regulation of raft-associated Akt signaling

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CELL DEATH & DISEASE (2011)

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Mechanisms for T cell receptor triggering

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NATURE REVIEWS IMMUNOLOGY (2011)

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Review Biophysics

Lipids and Cholesterol as Regulators of Traffic in the Endomembrane System

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ANNUAL REVIEW OF BIOPHYSICS, VOL 39 (2010)

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Article Biochemistry & Molecular Biology

StarD4-mediated translocation of 7-hydroperoxycholesterol to isolated mitochondria: Deleterious effects and implications for steroidogenesis under oxidative stress conditions

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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2010)

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Synergistic anti-inflammatory effects of low doses of curcumin in combination with polyunsaturated fatty acids: Docosahexaenoic acid or eicosapentaenoic acid

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BIOCHEMICAL PHARMACOLOGY (2010)

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Review Biochemistry & Molecular Biology

Lipid diffusion in planar membranes investigated by fluorescence correlation spectroscopy

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BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2010)

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Imaging Membrane Lipid Order in Whole, Living Vertebrate Organisms

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BIOPHYSICAL JOURNAL (2010)

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Adiponectin suppresses tumorigenesis in ApcMin/+ mice

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CANCER LETTERS (2010)

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Interaction between Adiponectin and Leptin Influences the Risk of Colorectal Adenoma

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CANCER RESEARCH (2010)

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De novo Lipogenesis Protects Cancer Cells from Free Radicals and Chemotherapeutics by Promoting Membrane Lipid Saturation

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CANCER RESEARCH (2010)

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Article Oncology

Docosahexaenoic acid alters epidermal growth factor receptor-related signaling by disrupting its lipid raft association

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A Comprehensive Comparison of Transmembrane Domains Reveals Organelle-Specific Properties

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CELL (2010)

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Cell-specific and lamin-dependent targeting of novel transmembrane proteins in the nuclear envelope

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CELLULAR AND MOLECULAR LIFE SCIENCES (2010)

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Genetics of lipid disorders

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CURRENT OPINION IN CARDIOLOGY (2010)

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The Hippo signaling pathway restricts the oncogenic potential of an intestinal regeneration program

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GENES & DEVELOPMENT (2010)

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Article Gastroenterology & Hepatology

Eicosapentaenoic acid reduces rectal polyp number and size in familial adenomatous polyposis

Nicholas J. West et al.

GUT (2010)

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Article Cell Biology

LRP6 is internalized by Dkk1 to suppress its phosphorylation in the lipid raft and is recycled for reuse

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JOURNAL OF CELL SCIENCE (2010)

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Stability elements in the LRP6 cytoplasmic tail confer efficient signalling upon DIX-dependent polymerization

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JOURNAL OF CELL SCIENCE (2010)

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Imaging with total internal reflection fluorescence microscopy for the cell biologist

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JOURNAL OF CELL SCIENCE (2010)

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Article Chemistry, Multidisciplinary

Switchable Nile Red-Based Probe for Cholesterol and Lipid Order at the Outer Leaflet of Biomembranes

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JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2010)

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Article Anatomy & Morphology

Optimized Time-Gated Generalized Polarization Imaging of Laurdan and di-4-ANEPPDHQ for Membrane Order Image Contrast Enhancement

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MICROSCOPY RESEARCH AND TECHNIQUE (2010)

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Article Biochemistry & Molecular Biology

Epidermal Growth Factor Receptor Activation Remodels the Plasma Membrane Lipid Environment To Induce Nanocluster Formation

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MOLECULAR AND CELLULAR BIOLOGY (2010)

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Article Endocrinology & Metabolism

Adiponectin Represses Colon Cancer Cell Proliferation via AdipoR1-and-R2-Mediated AMPK Activation

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MOLECULAR ENDOCRINOLOGY (2010)

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Article Biochemistry & Molecular Biology

High plasma membrane lipid order imaged at the immunological synapse periphery in live T cells

Dylan M. Owen et al.

MOLECULAR MEMBRANE BIOLOGY (2010)

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Article Medicine, Research & Experimental

Drug Resistance in Breast Cancer Cells: Biophysical Characterization of and Doxorubicin Interactions with Membrane Lipids

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MOLECULAR PHARMACEUTICS (2010)

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Article Immunology

TCR and Lat are expressed on separate protein islands on T cell membranes and concatenate during activation

Bjoern F. Lillemeier et al.

NATURE IMMUNOLOGY (2010)

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Review Cell Biology

Mitochondria and cell death: outer membrane permeabilization and beyond

Stephen W. G. Tait et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2010)

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Article Multidisciplinary Sciences

Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

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Article Multidisciplinary Sciences

Palmitoylation regulates raft affinity for the majority of integral raft proteins

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

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Article Biochemical Research Methods

Prediction of the human membrane proteome

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PROTEOMICS (2010)

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Review Multidisciplinary Sciences

Lipid Rafts As a Membrane-Organizing Principle

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SCIENCE (2010)

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Article Biochemistry & Molecular Biology

Phosphatidic acid signaling to mTOR: Signals for the survival of human cancer cells

David A. Foster

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2009)

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Article Oncology

Serum triglyceride concentrations and cancer risk in a large cohort study in Austria

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BRITISH JOURNAL OF CANCER (2009)

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Review Biochemistry & Molecular Biology

Metabolism, Cell Surface Organization, and Disease

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CELL (2009)

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Article Cell Biology

The differential protein and lipid compositions of noncaveolar lipid microdomains and caveolae

Yao Yao et al.

CELL RESEARCH (2009)

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Review Cell Biology

Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases

Bryan T. MacDonald et al.

DEVELOPMENTAL CELL (2009)

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Article Biochemistry & Molecular Biology

Accumulation of raft lipids in T-cell plasma membrane domains engaged in TCR signalling

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EMBO JOURNAL (2009)

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Article Immunology

The Constant Region of the Membrane Immunoglobulin Mediates B Cell-Receptor Clustering and Signaling in Response to Membrane Antigens

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IMMUNITY (2009)

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Article Biochemistry & Molecular Biology

TEAD Transcription Factors Mediate the Function of TAZ in Cell Growth and Epithelial-Mesenchymal Transition

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JOURNAL OF BIOLOGICAL CHEMISTRY (2009)

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Article Biochemistry & Molecular Biology

Lipin proteins and metabolic homeostasis

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JOURNAL OF LIPID RESEARCH (2009)

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Article Biochemistry & Molecular Biology

GM1-Ganglioside Accumulation at the Mitochondria-Associated ER Membranes Links ER Stress to Ca2+-Dependent Mitochondrial Apoptosis

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MOLECULAR CELL (2009)

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Article Multidisciplinary Sciences

Order of lipid phases in model and plasma membranes

Hermann-Josef Kaiser et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

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Article Biochemistry & Molecular Biology

Dietary docosahexaenoic and eicosapentaenoic acid: Emerging mediators of inflammation

Robert S. Chapkin et al.

PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS (2009)

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Review Oncology

The LKB1-AMPK pathway: metabolism and growth control in tumour suppression

David B. Shackelford et al.

NATURE REVIEWS CANCER (2009)

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Article Biochemistry & Molecular Biology

Docosahexaenoic acid alters the size and distribution of cell surface microdomains

Robert S. Chapkin et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2008)

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Article Oncology

A 22-year prospective study of fish, n-3 fatty acid intake, and colorectal cancer risk in men

Megan N. Hall et al.

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION (2008)

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Article Oncology

Mitochondrial cholesterol contributes to chemotherapy resistance in hepatocellular carcinoma

Joan Montero et al.

CANCER RESEARCH (2008)

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Article Cell Biology

Switch-like Control of SREBP-2 Transport Triggered by Small Changes in ER Cholesterol: A Delicate Balance

Arun Radhakrishnan et al.

CELL METABOLISM (2008)

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Review Cell Biology

Feedback regulation of cholesterol synthesis: sterol-accelerated ubiquitination and degradation of HMG CoA reductase

Russell A. DeBose-Boyd

CELL RESEARCH (2008)

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Review Biochemistry & Molecular Biology

Curcumin: From ancient medicine to current clinical trials

H. Hatcher et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2008)

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Review Biochemistry & Molecular Biology

N-3 polyunsaturated fatty acid regulation of hepatic gene transcription

Donald B. Jump

CURRENT OPINION IN LIPIDOLOGY (2008)

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Article Cell Biology

Wnt3a and Dkk1 regulate distinct internalization pathways of LRP6 to tune the activation of β-catenin signaling

Hideki Yamamoto et al.

DEVELOPMENTAL CELL (2008)

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Review Biochemistry & Molecular Biology

T-cell antigen receptor triggering and lipid rafts: a matter of space and time scales - Talking Point on the involvement of lipid rafts in T-cell activation

Hai-Tao He et al.

EMBO REPORTS (2008)

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Article Gastroenterology & Hepatology

Adiponectin suppresses colorectal carcinogenesis under the high-fat diet condition

T. Fujisawa et al.

GUT (2008)

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Article Immunology

Impaired TCR signaling through dysfunction of lipid rafts in sphingomyelin synthase 1 (SMS1)-knockdown T cells

Zhe-Xiong Jin et al.

INTERNATIONAL IMMUNOLOGY (2008)

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Article Biochemistry & Molecular Biology

Regulation of plasminogen activator inhibitor-1 expression by tumor suppressor protein p53

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JOURNAL OF BIOLOGICAL CHEMISTRY (2008)

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Article Biochemistry & Molecular Biology

Detection of Lipid Domains in Model and Cell Membranes by Fluorescence Lifetime Imaging Microscopy of Fluorescent Lipid Analogues

Martin Stoeckl et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2008)

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Article Biochemistry & Molecular Biology

Wnt signal amplification via activity, cooperativity, and regulation of multiple intracellular PPPSP motifs in the wnt co-receptor LRP6

Bryan T. MacDonald et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2008)

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Article Immunology

n-3 Polyunsaturated Fatty Acids Suppress the Localization and Activation of Signaling Proteins at the Immunological Synapse in Murine CD4+ T Cells by Affecting Lipid Raft Formation

Wooki Kim et al.

JOURNAL OF IMMUNOLOGY (2008)

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Article Biochemistry & Molecular Biology

Electrostatic interactions positively regulate K-ras nanocluster formation and function

Sarah J. Plowman et al.

MOLECULAR AND CELLULAR BIOLOGY (2008)

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Article Cell Biology

Lipid Microdomains in Cell Nucleus

Giacomo Cascianelli et al.

MOLECULAR BIOLOGY OF THE CELL (2008)

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Article Biochemical Research Methods

High-density mapping of single-molecule trajectories with photoactivated localization microscopy

Suliana Manley et al.

NATURE METHODS (2008)

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Review Cell Biology

A complex barcode underlies the heterogeneous response of p53 to stress

Fiona Murray-Zmijewski et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2008)

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Review Cell Biology

Membrane lipids: where they are and how they behave

Gerrit van Meer et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2008)

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Article Multidisciplinary Sciences

Functional Implications of Plasma Membrane Condensation for T Cell Activation

Carles Rentero et al.

PLOS ONE (2008)

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Review Biochemical Research Methods

Proteomics of mitochondrial inner and outer membranes

Anne M. Distler et al.

PROTEOMICS (2008)

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Article Biochemistry & Molecular Biology

Surface-anchored monomeric agonist pMHCs alone trigger TCR with high sensitivity

Zhengyu Ma et al.

PLOS BIOLOGY (2008)

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Article Biochemistry & Molecular Biology

Bax activation and stress-induced apoptosis delayed by the accumulation of cholesterol in mitochondrial membranes

S. Lucken-Ardjomande et al.

CELL DEATH AND DIFFERENTIATION (2008)

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Article Multidisciplinary Sciences

Regulation of p53 tetramerization and nuclear export by ARC

Roger S. -Y. Foo et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

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Article Biophysics

Effect of the structure of lipids favoring disordered domain formation on the stability of cholesterol-containing ordered domains (lipid rafts): Identification of multiple raft-stabilization mechanisms

Omar Bakht et al.

BIOPHYSICAL JOURNAL (2007)

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Article Biochemistry & Molecular Biology

YAP1 increases organ size and expands undifferentiated progenitor cells

Fernando D. Camargo et al.

CURRENT BIOLOGY (2007)

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Article Oncology

Relationship between p53 and p27 expression following HER2 signaling

Patrizia Casalini et al.

BREAST (2007)

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Article Biochemistry & Molecular Biology

Plasma membrane rafts complete cholesterol synthesis by participating in retrograde movement of precursor sterols

Yoshio Yamauchi et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2007)

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Review Biochemistry & Molecular Biology

Polyphenolic phytochemicals - just antioxidants or much more?

D. E. Stevenson et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2007)

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Article Biochemistry & Molecular Biology

Identification of an ABCA1-dependent phospholipid-rich plasma membrane apolipoprotein A-I binding site for nascent HDL formation: implications for current models of HDL biogenesis

Houssein Hajj Hassan et al.

JOURNAL OF LIPID RESEARCH (2007)

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Article Medicine, Research & Experimental

Macrophage-specific transgenic expression of cholesteryl ester hydrolase significantly reduces atherosclerosis and lesion necrosis in Ldlr-/- mice

Bin Zhao et al.

JOURNAL OF CLINICAL INVESTIGATION (2007)

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Review Biochemistry & Molecular Biology

Functions of cell surface galectin-glycoprotein lattices

Gabriel A. Rabinovich et al.

CURRENT OPINION IN STRUCTURAL BIOLOGY (2007)

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Article Cell Biology

Plasma membrane nanoswitches generate high-fidelity Ras signal transduction

Tianhai Tian et al.

NATURE CELL BIOLOGY (2007)

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Article Gastroenterology & Hepatology

Eicosapentaenoic acid (EPA) reduces crypt cell proliferation and increases apoptosis in normal colonic mucosa in subjects with a history of colorectal adenomas

E. D. Courtney et al.

INTERNATIONAL JOURNAL OF COLORECTAL DISEASE (2007)

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Article Multidisciplinary Sciences

Wnt induces LRP6 signalosomes and promotes dishevelled-dependent LRP6 phosphorylation

Josipa Bilic et al.

SCIENCE (2007)

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Review Biochemistry & Molecular Biology

Steroidogenic acute regulatory protein (StAR), a novel mitochondrial cholesterol transporter

Walter L. Miller

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2007)

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Review Biochemistry & Molecular Biology

Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer

P. J. Roberts et al.

ONCOGENE (2007)

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Article Chemistry, Analytical

Secondary ion MS imaging to relatively quantify cholesterol in the membranes of individual cells from differentially treated populations

Sara G. Ostrowski et al.

ANALYTICAL CHEMISTRY (2007)

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Review Biochemistry & Molecular Biology

MAP kinase signalling pathways in cancer

A. S. Dhillon et al.

ONCOGENE (2007)

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Article Biophysics

Formation of three-dimensional structures in supported lipid bilayers

Lee R. Cambrea et al.

BIOPHYSICAL JOURNAL (2007)

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Article Multidisciplinary Sciences

Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: Oxysterols block transport by binding to Insig

Arun Radhakrishnan et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

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Article Multidisciplinary Sciences

Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: Insig renders sorting signal in Scap inaccessible to COPII proteins

Li-Ping Sun et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

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Article Biochemistry & Molecular Biology

Peripheral-type benzodiazepine receptor (PBR) aggregation and absence of steroidogenic acute regulatory protein (StAR)/PBR association in the mitochondrial membrane as determined by bioluminescence resonance energy transfer (BRET)

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JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2007)

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Article Biochemistry & Molecular Biology

A two-photon fluorescent probe for lipid raft imaging: C-laurdan

Hwan Myung Kim et al.

CHEMBIOCHEM (2007)

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Article Endocrinology & Metabolism

Omega-3 fatty acids, pro-inflammatory signaling and neuroprotection

Nicolas G. Bazan

CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE (2007)

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Article Nutrition & Dietetics

(n-3) PUFA alter raft lipid composition and decrease epidermal growth factor receptor levels in lipid rafts of human breast cancer cells

Patricia D. Schley et al.

JOURNAL OF NUTRITION (2007)

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Article Cell Biology

Is there a mitochondrial signaling complex facilitating cholesterol import?

Vassilios Papadopoulos et al.

MOLECULAR AND CELLULAR ENDOCRINOLOGY (2007)

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Review Gastroenterology & Hepatology

Colon cancer, fatty acids and anti-inflammatory compounds

Robert S. Chapkin et al.

CURRENT OPINION IN GASTROENTEROLOGY (2007)

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Review Immunology

Resolvins and protectins in the termination program of acute inflammation

Amirarn Ariel et al.

TRENDS IN IMMUNOLOGY (2007)

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Review Cell Biology

p53 in health and disease

Karen H. Vousden et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2007)

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Article Gastroenterology & Hepatology

Curcumin maintenance therapy for ulcerative colitis: Randomized, multicenter, double-blind, placebo-controlled trial

Hiroyuki Hanai et al.

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2006)

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Review Cardiac & Cardiovascular Systems

ATP-binding cassette cholesterol transporters and cardiovascular disease

John F. Oram et al.

CIRCULATION RESEARCH (2006)

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Review Biochemistry & Molecular Biology

Wnt/β-catenin signaling in development and disease

Hans Clevers

CELL (2006)

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Review Chemistry, Physical

ToF-SIMS imaging of lipids in cell membranes

Bjorn Johansson

SURFACE AND INTERFACE ANALYSIS (2006)

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Article Hematology

Decreased atherosclerosis in low-density lipoprotein receptor knockout mice transplanted with Abcg1-/- bone marrow

Mollie Ranalletta et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2006)

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Article Hematology

Macrophage ABCG1 deletion disrupts lipid homeostasis in alveolar macrophages and moderately influences atherosclerotic lesion development in LDL receptor-deficient mice

Ruud Out et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2006)

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Article Hematology

Impaired development of atherosclerosis in hyperlipidemic Ldlr-/- and ApoE -/- mice transplanted with Abcg1-/- bone marrow

Angela Baldan et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2006)

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Review Cell Biology

Biophysical properties of lipids and dynamic membranes

P. A. Janmey et al.

TRENDS IN CELL BIOLOGY (2006)

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Article Biochemistry & Molecular Biology

Clustering of raft-associated proteins in the external membrane leaflet modulates internal leaflet H-Ras diffusion and signaling

Sharon Eisenberg et al.

MOLECULAR AND CELLULAR BIOLOGY (2006)

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Article Cell Biology

Structural and functional features and significance of the physical linkage between ER and mitochondria

Gyorgy Csordas et al.

JOURNAL OF CELL BIOLOGY (2006)

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Review Biochemistry & Molecular Biology

Functions of the MAPK family in vertebrate-development

S. F. Gabby Krens et al.

FEBS LETTERS (2006)

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Article Biochemistry & Molecular Biology

Microtubules and actin microfilaments regulate lipid raft/caveolae localization of adenylyl cyclase signaling components

Brian P. Head et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

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Article Cell Biology

Lipin 1 is an inducible amplifier of the hepatic PGC-1α/PPARα regulatory pathway

Brian N. Finck et al.

CELL METABOLISM (2006)

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Article Cell Biology

Caveolin is necessary for Wnt-3a-dependent internalization of LRP6 and accumulation of β-catenin

Hideki Yamamoto et al.

DEVELOPMENTAL CELL (2006)

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Article Gastroenterology & Hepatology

Combination treatment with curcumin and quercetin of adenomas in familial adenomatous polyposis

Marcia Cruz-Correa et al.

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2006)

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Article Chemistry, Physical

Imaging lipid distributions in model monolayers by ToF-SIMS with selectively deuterated components and principal components analysis

Mark C. Biesinger et al.

APPLIED SURFACE SCIENCE (2006)

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Article Chemistry, Physical

Investigating lipid interactions and the process of raft formation in cellular membranes using ToF-SIMS

Carolyn M. McQuaw et al.

APPLIED SURFACE SCIENCE (2006)

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Article Biochemistry & Molecular Biology

TIGAR, a p53-inducible regulator of glycolysis and apoptosis

Karim Bensaad et al.

CELL (2006)

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Article Biochemical Research Methods

Lipidomics: An analysis of cellular lipids by ESI-MS

Stephen Milne et al.

METHODS (2006)

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Review Oncology

Adiponectin and cancer: a systematic review

I Kelesidis et al.

BRITISH JOURNAL OF CANCER (2006)

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Review Biochemistry & Molecular Biology

Signaling functions of phosphatidic acid

Xuemin Wang et al.

PROGRESS IN LIPID RESEARCH (2006)

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Article Cell Biology

Nonvesicular sterol movement from plasma membrane to ER requires oxysterol-binding protein-related proteins and phosphoinositides

S Raychaudhuri et al.

JOURNAL OF CELL BIOLOGY (2006)

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Article Pathology

Elevated levels of cholesterol-rich lipid rafts in cancer cells are correlated with apoptosis sensitivity induced by cholesterol-depleting agents

YC Li et al.

AMERICAN JOURNAL OF PATHOLOGY (2006)

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Article Biophysics

Characterization and application of a new optical probe for membrane lipid domains

L Jin et al.

BIOPHYSICAL JOURNAL (2006)

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Article Medicine, Research & Experimental

Intestinal ABCA1 directly contributes to HDL biogenesis in vivo

LR Brunham et al.

JOURNAL OF CLINICAL INVESTIGATION (2006)

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Review Cardiac & Cardiovascular Systems

Involvement of lipid rafts and caveolae in cardiac ion channel function

A Maguy et al.

CARDIOVASCULAR RESEARCH (2006)

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Article Biochemistry & Molecular Biology

Mice lacking adiponectin show decreased hepatic insulin sensitivity and reduced responsiveness to peroxisome proliferator-activated receptor γ agonists

AR Nawrocki et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

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Article Biochemistry & Molecular Biology

Docosahexaenoic acid selectively inhibits plasma membrane targeting of lipidated proteins

Jeongmin Seo et al.

FASEB JOURNAL (2006)

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Review Biochemistry & Molecular Biology

Protein sensors for membrane sterols

JL Goldstein et al.

CELL (2006)

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Review Biochemistry & Molecular Biology

Lipid rafts in T cell receptor signalling (Review)

PS Kabouridis

MOLECULAR MEMBRANE BIOLOGY (2006)

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Review Biochemistry & Molecular Biology

Membrane-lipid therapy: a new approach in molecular medicine

PV Escriba

TRENDS IN MOLECULAR MEDICINE (2006)

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Review Cell Biology

Lipid rafts: contentious only from simplistic standpoints

John F. Hancock

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2006)

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Review Biochemistry & Molecular Biology

Growth factor receptors, lipid rafts and caveolae: An evolving story

LJ Pike

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2005)

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Article Immunology

Newly generated T cell receptor microclusters initiate and sustain T cell activation by recruitment of Zap70 and SLP-76

T Yokosuka et al.

NATURE IMMUNOLOGY (2005)

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Review Multidisciplinary Sciences

Role of cholesterol and lipid organization in disease

FR Maxfield et al.

NATURE (2005)

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Article Oncology

Low plasma adiponectin levels and risk of colorectal cancer in men: A prospective study

EK Wei et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2005)

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Article Multidisciplinary Sciences

H-ras, K-ras, and inner plasma membrane raft proteins operate in nanoclusters with differential dependence on the actin cytoskeleton

SJ Plowman et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

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Article Cell Biology

Condensation of the plasma membrane at the site of T lymphocyte activation

K Gaus et al.

JOURNAL OF CELL BIOLOGY (2005)

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Review Biochemistry & Molecular Biology

The nuclear membrane proteome: extending the envelope

EC Schirmer et al.

TRENDS IN BIOCHEMICAL SCIENCES (2005)

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Review Biochemistry & Molecular Biology

Bridging gaps in phospholipid transport

DR Voelker

TRENDS IN BIOCHEMICAL SCIENCES (2005)

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Article Biophysics

Cholesterol-enriched lipid domains can be visualized by di-4-ANEPPDHQ with linear and nonlinear optics

L Jin et al.

BIOPHYSICAL JOURNAL (2005)

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Article Biochemistry & Molecular Biology

Single-molecule microscopy reveals plasma membrane microdomains created by protein-protein networks that exclude or trap signaling molecules in T cells

AD Douglass et al.

CELL (2005)

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Article Cell Biology

Relationships between EGFR signaling-competent and endocytosis-competent membrane microdomains

C Puri et al.

MOLECULAR BIOLOGY OF THE CELL (2005)

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Article Biochemistry & Molecular Biology

Transport of newly synthesized sterol to the sterol-enriched plasma membrane occurs via nonvesicular equilibration

[Anonymous]

BIOCHEMISTRY (2005)

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Article Multidisciplinary Sciences

Wnt signalling in stem cells and cancer

T Reya et al.

NATURE (2005)

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Article Medicine, General & Internal

Cardiovascular events associated with rofecoxib in a colorectal adenoma chemoprevention trial

RS Bresalier et al.

NEW ENGLAND JOURNAL OF MEDICINE (2005)

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Article Multidisciplinary Sciences

Sterol structure determines the separation of phases and the curvature of the liquid-ordered phase in model membranes

K Bacia et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

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Review Biochemistry & Molecular Biology

A comprehensive pathway map of epidermal growth factor receptor signaling

Kanae Oda et al.

MOLECULAR SYSTEMS BIOLOGY (2005)

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Review Oncology

Galectins as modulators of tumour progression

FT Liu et al.

NATURE REVIEWS CANCER (2005)

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Review Biochemistry & Molecular Biology

Plasma membrane microdomains: organization, function and trafficking (Review)

AJ Laude et al.

MOLECULAR MEMBRANE BIOLOGY (2004)

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Review Genetics & Heredity

Endogenous DNA damage in humans: a review of quantitative data

R De Bont et al.

MUTAGENESIS (2004)

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Article Biochemical Research Methods

Novel naphthylstyryl-pyridinium potentiometric dyes offer advantages for neural network analysis

AL Obaid et al.

JOURNAL OF NEUROSCIENCE METHODS (2004)

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Article Biochemistry & Molecular Biology

n-3 PUFA Alter caveolae lipid composition and resident protein localization in mouse colon

DWL Ma et al.

FASEB JOURNAL (2004)

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Review Cell Biology

Molecular dynamics and interactions for creation of stimulation-induced stabilized rafts from small unstable steady-state rafts

A Kusumi et al.

TRAFFIC (2004)

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Article Biochemistry & Molecular Biology

Galectin-3 precipitates as a pentamer with synthetic multivalent carbohydrates and forms heterogeneous cross-linked complexes

N Ahmad et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

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Review Biochemistry & Molecular Biology

Genetic analysis of intracellular aminoglycerophospholipid traffic

DR Voelker

BIOCHEMISTRY AND CELL BIOLOGY (2004)

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Article Oncology

Chemopreventive n-3 polyunsaturated fatty acids reprogram genetic signatures during colon cancer initiation and progression in the rat

LA Davidson et al.

CANCER RESEARCH (2004)

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Article Biochemistry & Molecular Biology

Lipin expression preceding peroxisome proliferator-activated receptor-γ is critical for adipogenesis in vivo and in vitro

J Phan et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

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Article Biochemistry & Molecular Biology

Subcellular localization of VDAC in mitochondria and ER in the cerebellum

V Shoshan-Barmatz et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS (2004)

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Review Hematology

Intracellular cholesterol transport

RE Soccio et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2004)

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Article Biochemistry & Molecular Biology

The interaction of flavonoids with membranes: Potential determinant of flavonoid antioxidant effects

AG Erlejman et al.

FREE RADICAL RESEARCH (2004)

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Article Multidisciplinary Sciences

Phospholipid metabolism regulated by a transcription factor sensing phosphatidic acid

CJR Loewen et al.

SCIENCE (2004)

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Article Biochemistry & Molecular Biology

n-3 PUFA and membrane microdomains:: a new frontier in bioactive lipid research

DWL Ma et al.

JOURNAL OF NUTRITIONAL BIOCHEMISTRY (2004)

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Article Oncology

Phase I clinical trial of oral curcumin: Biomarkers of systemic activity and compliance

RA Sharma et al.

CLINICAL CANCER RESEARCH (2004)

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Review Biochemistry & Molecular Biology

The pathophysiology and mechanisms of NP-C disease

SL Sturley et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2004)

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Article Biochemistry & Molecular Biology

Tumor-derived p53 mutants induce oncogenesis by transactivating growth-promoting genes

MJ Scian et al.

ONCOGENE (2004)

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Article Multidisciplinary Sciences

Imaging coexisting fluid domains in biomembrane models coupling curvature and line tension

T Baumgart et al.

NATURE (2003)

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Article Cell Biology

Integral role of Noxa in p53-mediated apoptotic response

T Shibue et al.

GENES & DEVELOPMENT (2003)

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Article Oncology

Chemopreventive n-3 fatty acids activate RXRα in colonocytes

YY Fan et al.

CARCINOGENESIS (2003)

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Article Immunology

T cell glycolipid-enriched membrane domains are constitutively assembled as membrane patches that translocate to immune synapses

S Jordan et al.

JOURNAL OF IMMUNOLOGY (2003)

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Article Biochemistry & Molecular Biology

Differential mobilization of newly synthesized cholesterol and biosynthetic sterol precursors from cells

S Lusa et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2003)

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Article Multidisciplinary Sciences

Resistance of cell membranes to different detergents

S Schuck et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)

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Review Cell Biology

Ras proteins: Different signals from different locations

JF Hancock

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2003)

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Article Cell Biology

START domain proteins and the intracellular trafficking of cholesterol in steroidogenic cells

JF Strauss et al.

MOLECULAR AND CELLULAR ENDOCRINOLOGY (2003)

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Article Medicine, General & Internal

Overweight, obesity, and mortality from cancer in a prospectively studied cohort of US adults

EE Calle et al.

NEW ENGLAND JOURNAL OF MEDICINE (2003)

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Review Biochemistry & Molecular Biology

Lipid rafts: bringing order to chaos

LJ Pike

JOURNAL OF LIPID RESEARCH (2003)

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Article Biophysics

Cholesterol-induced protein sorting:: An analysis of energetic feasibility

JA Lundbæk et al.

BIOPHYSICAL JOURNAL (2003)

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Article Multidisciplinary Sciences

PUMA mediates the apoptotic response to p53 in colorectal cancer cells

J Yu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)

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Article Medical Laboratory Technology

Biochemical changes in tumor tissues of oral cancer patients

K Kolanjiappan et al.

CLINICAL BIOCHEMISTRY (2003)

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Article Oncology

PTEN tumor suppressor regulates p53 protein levels and activity through phosphatase-dependent and -independent mechanisms

DJ Freeman et al.

CANCER CELL (2003)

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Article Cell Biology

Direct visualization of Ras proteins in spatially distinct cell surface microdomains

IA Prior et al.

JOURNAL OF CELL BIOLOGY (2003)

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Article Biochemistry & Molecular Biology

Basolateral targeting by leucine-rich repeat domains in epithelial cells

R Legouis et al.

EMBO REPORTS (2003)

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Review Biochemistry & Molecular Biology

Effects of membrane lipids on ion channel structure and function

TS Tillman et al.

CELL BIOCHEMISTRY AND BIOPHYSICS (2003)

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Article Biochemistry & Molecular Biology

The fence and picket structure of the plasma membrane of live cells as revealed by single molecule techniques (Review)

K Ritchie et al.

MOLECULAR MEMBRANE BIOLOGY (2003)

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Article Nutrition & Dietetics

Fatty acid composition of skeletal muscle reflects dietary fat composition in humans

A Andersson et al.

AMERICAN JOURNAL OF CLINICAL NUTRITION (2002)

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Article Biochemistry & Molecular Biology

Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase

T Yamauchi et al.

NATURE MEDICINE (2002)

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Review Biochemistry & Molecular Biology

Clusters, bundles, arrays and lattices: novel mechanisms for lectin-saccharide-mediated cellular interactions

CF Brewer et al.

CURRENT OPINION IN STRUCTURAL BIOLOGY (2002)

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Article Biochemistry & Molecular Biology

Differential sorting and fate of endocytosed GPI-anchored proteins

M Fivaz et al.

EMBO JOURNAL (2002)

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Article Cell Biology

Activated K-Ras and H-Ras display different interactions with saturable nonraft sites at the surface of live cells

H Niv et al.

JOURNAL OF CELL BIOLOGY (2002)

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Review Oncology

HMG-CoA reductase inhibitors and the malignant cell: the statin family of drugs as triggers of tumor-specific apoptosis

WWL Wong et al.

LEUKEMIA (2002)

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Article Biochemistry & Molecular Biology

ERp44, a novel endoplasmic reticulum folding assistant of the thioredoxin family

T Anelli et al.

EMBO JOURNAL (2002)

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Review Immunology

Lipid rafts and B-cell activation

SK Pierce

NATURE REVIEWS IMMUNOLOGY (2002)

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Article Multidisciplinary Sciences

Nuclear envelope proteomics:: Novel integral membrane proteins of the inner nuclear membrane

M Dreger et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)

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Article Biophysics

Elastic thickness compressibilty of the red cell membrane

V Heinrich et al.

BIOPHYSICAL JOURNAL (2001)

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Article Biochemistry & Molecular Biology

Human mdm2 mediates multiple mono-ubiquitination of p53 by a mechanism requiring enzyme isomerization

ZH Lai et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2001)

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Article Oncology

Dietary fat, cholesterol and colorectal cancer in a prospective study

R Järvinen et al.

BRITISH JOURNAL OF CANCER (2001)

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Review Chemistry, Multidisciplinary

MAP kinases

Z Chen et al.

CHEMICAL REVIEWS (2001)

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Article Immunology

Lipid rafts and HIV pathogenesis: Host membrane cholesterol is required for infection by HIV type 1

ZH Liao et al.

AIDS RESEARCH AND HUMAN RETROVIRUSES (2001)

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Article Biochemistry & Molecular Biology

Apaf-1 localization is modulated indirectly by Bcl-2 expression

A Ruiz-Vela et al.

FEBS LETTERS (2001)

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Review Physiology

Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation

JM Kyriakis et al.

PHYSIOLOGICAL REVIEWS (2001)

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Article Biochemistry & Molecular Biology

BCL-2 is involved in preventing oxidant-induced cell death and in decreasing oxygen radical production

PA Amstad et al.

REDOX REPORT (2001)

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Article Oncology

Effect of phosphatidic acid on human breast cancer cells exposed to doxorubicin

D Sliva et al.

CANCER INVESTIGATION (2001)

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Review Biochemistry & Molecular Biology

Interaction of membrane proteins and lipids with solubilizing detergents

M le Maire et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2000)

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Article Biochemistry & Molecular Biology

Phosphatidylserine synthase-1 and-2 are localized to mitochondria-associated membranes

SJ Stone et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2000)

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Article Biochemistry & Molecular Biology

Differences in mutant p53 protein stability and functional activity in teniposide-sensitive and -resistant human leukemic CEM cells

SE Morgan et al.

ONCOGENE (2000)

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Review Cell Biology

Lipid rafts and signal transduction

K Simons et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2000)

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Article Multidisciplinary Sciences

Dissecting the role of the Golgi complex and lipid rafts in biosynthetic transport of cholesterol to the cell surface

S Heino et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)

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Review Biochemistry & Molecular Biology

Structure and function of sphingolipid- and cholesterol-rich membrane rafts

DA Brown et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2000)

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