4.7 Article

Ceramide nanoliposomes augment the efficacy of venetoclax and cytarabine in models of acute myeloid leukemia

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Hematology

Cotargeting of Bcl-2 and Mcl-1 shows promising antileukemic activity against AML cells including those with acquired cytarabine resistance

Fangbing Liu et al.

Summary: The study demonstrated the synergistic effect of Mcl-1 inhibitor S63845 in combination with venetoclax in AML cells, inducing intrinsic apoptosis to combat AML, including resistant cells. This combination shows promise in overcoming resistance and treating relapse/refractory AML.

EXPERIMENTAL HEMATOLOGY (2022)

Article Genetics & Heredity

SynergyFinder Plus: Toward Better Interpretation and Annotation of Drug Combination Screening Datasets

Shuyu Zheng et al.

Summary: The SynergyFinder R package is a software that analyzes drug combination data, offering features such as high-order data analysis, statistical analysis, evaluation of synergy, and fast annotation. It provides improved interpretation and annotation of drug combination screening results.

GENOMICS PROTEOMICS & BIOINFORMATICS (2022)

Article Hematology

Ceramide-induced integrated stress response overcomes Bcl-2 inhibitor resistance in acute myeloid leukemia

Alexander C. Lewis et al.

Summary: In this study, the accumulation of ceramide in AML cells induced an apoptotic integrated stress response through the activation of transcription factor ATF4. This response led to the degradation of the prosurvival protein Mcl-1, resulting in cell death. Combination treatment with the Bcl-2 inhibitor venetoclax synergistically killed AML cells and reduced leukemic stem cells.
Review Oncology

Acute myeloid leukemia: current progress and future directions

Hagop Kantarjian et al.

Summary: Advancements in understanding and therapy of AML have been rapid, with targeted therapies such as venetoclax and FLT3 inhibitors being approved for various indications. Expertise is crucial in managing the complexity of AML treatment, tailored to the specific subentities for optimal outcomes.

BLOOD CANCER JOURNAL (2021)

Review Oncology

The Role of Ceramide Metabolism and Signaling in the Regulation of Mitophagy and Cancer Therapy

Megan Sheridan et al.

Summary: Sphingolipids are membrane-associated lipids that play crucial roles in regulating cell functions such as proliferation, migration, senescence, and death. In cancer cells, sphingolipids are involved in pathways relevant to cancer therapy, including invasion, metastasis, apoptosis, and lethal mitophagy. Notable sphingolipids like ceramide and sphingosine-1 phosphate have contrasting effects on cell survival and chemotherapeutic resistance, with ceramide inducing death and lethal mitophagy, and sphingosine-1 phosphate promoting survival. These lipids are characterized by a long-chain sphingosine backbone linked to a fatty acyl chain with variable length, and alterations in ceramide synthases and sphingolipid regulation of mitophagy have important implications for cancer therapy.

CANCERS (2021)

Article Oncology

Metformin exerts a synergistic effect with venetoclax by downregulating Mcl-1 protein in acute myeloid leukemia

Fang-jiao Zhou et al.

Summary: Metformin downregulates the expression of anti-apoptotic proteins Mcl-1 and Bcl-xl by inhibiting protein production, and shows a synergistic anti-tumor effect with ABT-199 in acute myeloid leukemia.

JOURNAL OF CANCER (2021)

Article Hematology

The novel Isatin analog KS99 targets stemness markers in acute myeloid leukemia

Charyguly Annageldiyev et al.

HAEMATOLOGICA (2020)

Article Multidisciplinary Sciences

Effect of CHK1 Inhibition on CPX-351 Cytotoxicity in vitro and ex vivo

Nicole D. Vincelette et al.

SCIENTIFIC REPORTS (2019)

Article Biochemistry & Molecular Biology

Plasma concentrations of molecular lipid species predict long-term clinical outcome in coronary artery disease patients

Sharda Anroedh et al.

JOURNAL OF LIPID RESEARCH (2018)

Editorial Material Biochemistry & Molecular Biology

The ceramide ratio: a predictor of cardiometabolic risk

Trevor S. Tippetts et al.

JOURNAL OF LIPID RESEARCH (2018)

Review Oncology

Pathways and mechanisms of venetoclax resistance

Prithviraj Bose et al.

LEUKEMIA & LYMPHOMA (2017)

Article Multidisciplinary Sciences

Lipidomic approach for stratification of acute myeloid leukemia patients

Adam Stefanko et al.

PLOS ONE (2017)

Article Biochemistry & Molecular Biology

Ceramide synthases in biomedical research

Francesca Cingolani et al.

CHEMISTRY AND PHYSICS OF LIPIDS (2016)

Article Medicine, General & Internal

Genomic Classification and Prognosis in Acute Myeloid Leukemia

Elli Papaemmanuil et al.

NEW ENGLAND JOURNAL OF MEDICINE (2016)

Article Biochemistry & Molecular Biology

CHK1 as a therapeutic target to bypass chemoresistance in AML

Laure David et al.

SCIENCE SIGNALING (2016)

Review Oncology

Acute myeloid leukemia: a comprehensive review and 2016 update

I. De Kouchkovsky et al.

BLOOD CANCER JOURNAL (2016)

Article Biochemistry & Molecular Biology

CHK1 as a therapeutic target to bypass chemoresistance in AML

Laure David et al.

SCIENCE SIGNALING (2016)

Review Biochemistry & Molecular Biology

Preclinical development of a C6-ceramide NanoLiposome, a novel sphingolipid therapeutic

Mark Kester et al.

BIOLOGICAL CHEMISTRY (2015)

Article Oncology

Cancer Statistics, 2015

Rebecca L. Siegel et al.

CA-A CANCER JOURNAL FOR CLINICIANS (2015)

Review Oncology

Roles of Chk1 in cell biology and cancer therapy

Youwei Zhang et al.

INTERNATIONAL JOURNAL OF CANCER (2014)

Review Oncology

Ceramide-orchestrated signalling in cancer cells

Samy A. F. Morad et al.

NATURE REVIEWS CANCER (2013)

Article Biochemistry & Molecular Biology

Long chain ceramides and very long chain ceramides have opposite effects on human breast and colon cancer cell growth

Daniela Hartmann et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2012)

Article Medicine, General & Internal

Prognostic Relevance of Integrated Genetic Profiling in Acute Myeloid Leukemia

Jay P. Patel et al.

NEW ENGLAND JOURNAL OF MEDICINE (2012)

Review Biochemistry & Molecular Biology

Sphingolipid players in the leukemia arena

Clara Ricci et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2006)