期刊
EXPERT REVIEW OF CLINICAL IMMUNOLOGY
卷 18, 期 11, 页码 1145-1154出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/1744666X.2022.2123795
关键词
Primary immunodeficiency; inborn errors of immunity; humoral immunity; B cell; class switch recombination; cytokines; transcription factors
类别
资金
- Anna-Greta Crafoords foundation
This article provides an overview of the tight regulation of B cells during the process of immunoglobulin class switch recombination (CSR) and its implications in immune-related clinical manifestations. Defects in CSR can contribute to various diseases.
Introduction The process of immunoglobulin class switch recombination (CSR) occurs in secondary lymphoid organs. This highly regulated process is essential for the development of different antibody isotype maturation and long-life memory/plasma cell generation. Patients with impaired CSR present heterogeneous noninfectious complications. Areas covered We provide an overview of recent advancements in the tight regulation of B cells before and during the CSR at different levels of cytokine stimulations, intracellular signaling, transcription-factor activation, gene transcription, and epigenetic controls. Expert opinion Besides recurrent infections which result from the lack of production of class-switched immunoglobulins, intrinsic B cell signaling pathways and regulatory component defects have distinct roles in other immune-related clinical manifestations including autoimmunity, atopy, lymphoproliferation, and cancer.
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