Tailored biological treatment for patients with moderate-to-severe psoriasis

Editorial Material Pharmacology & Pharmacy

Refining targeted therapeutic approaches in pancreatic cancer: from histology and molecular pathology to the clinic

Paola Mattiolo et al.

EXPERT OPINION ON THERAPEUTIC TARGETS (2022)

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Article Dermatology

Association Between Short-term Exposure to Environmental Air Pollution and Psoriasis Flare

Francesco Bellinato et al.

Summary: The findings of this study suggest that air pollution may be a trigger factor for psoriasis flare.

JAMA DERMATOLOGY (2022)

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Article Rheumatology

Biological disease-modifying antirheumatic drugs may mitigate the risk of psoriatic arthritis in patients with chronic plaque psoriasis

Paolo Gisondi et al.

Summary: In patients with moderate-to-severe chronic plaque psoriasis, treatment with bDMARDs may delay or reduce the risk of incident PsA. The annual incidence rate of PsA was significantly lower in the bDMARDs group compared to the phototherapy group. Factors associated with a higher risk of PsA included older age, nail psoriasis, and psoriasis duration over 10 years.

ANNALS OF THE RHEUMATIC DISEASES (2022)

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Article Rheumatology

Treating the skin with biologics in patients with psoriasis decreases the incidence of psoriatic arthritis

Maria Laura Acosta Felquer et al.

Summary: The study found that using biologics in patients with psoriasis can reduce the risk of developing psoriatic arthritis (PsA).

ANNALS OF THE RHEUMATIC DISEASES (2022)

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Review Dermatology

Biomarkers of systemic treatment response in people with psoriasis: a scoping review

Mark Corbett et al.

Summary: This review presents a comprehensive catalog of investigated biomarkers of systemic treatment response in psoriasis. The included studies found diverse types of biomarkers and outcomes, serving as a key resource for the translational research community.

BRITISH JOURNAL OF DERMATOLOGY (2022)

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Review Rheumatology

Aggravation of discoid lupus erythematosus in a patient with psoriasis and psoriatic arthritis during treatment of secukinumab: A case report and review of literature

Chang-Yu Hsieh et al.

Summary: The coexistence of psoriasis and cutaneous lupus erythematosus (LE) is uncommon and treatment is challenging. Targeting the Th17 pathway with biologics may be an effective treatment for patients with concomitant psoriasis and LE.

LUPUS (2022)

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Article Immunology

Cost per Responder Analysis of Secukinumab versus Adalimumab in the Treatment of Psoriatic Disease

Paolo Gisondi et al.

Summary: This study compared the cost per responder of secukinumab and adalimumab in patients with psoriatic disease. The results showed that the costs per responder for psoriatic arthritis endpoints were similar for both drugs, but secukinumab had lower costs for psoriasis and composite endpoints.

VACCINES (2022)

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Article Dermatology

Real-Life Effectiveness of Adalimumab Biosimilars in Patients with Chronic Plaque Psoriasis

Francesco Bellinato et al.

Summary: This study investigated the drug survival of adalimumab biosimilars in patients with chronic plaque psoriasis and found a high survival rate at 1 year. Obesity was associated with an increased risk of discontinuation, while psoriatic arthritis and receiving adalimumab as first systemic treatment were associated with a lower risk.

DERMATOLOGY AND THERAPY (2022)

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Article Dermatology

Occurrence of inflammatory bowel disease in patients with chronic inflammatory skin diseases: a cohort study

Maria C. Schneeweiss et al.

Summary: Patients with hidradenitis suppurativa have an increased risk of inflammatory bowel disease (IBD), particularly ulcerative colitis (UC) and Crohn's disease (CD). Patients with psoriasis have an increased risk of CD but not UC. Patients with atopic dermatitis, alopecia areata, or vitiligo do not have an increased risk of IBD.

BRITISH JOURNAL OF DERMATOLOGY (2022)

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Article Radiology, Nuclear Medicine & Medical Imaging

Meta-Analysis of the Efficacy and Safety of Interleukin-23-Targeted Drugs in the Treatment of Moderate-to-Severe Psoriasis

Teng Zhu et al.

Summary: This study systematically evaluated the efficacy and safety of IL-23-targeted drugs in the treatment of moderate-to-severe psoriasis. The results showed that IL-23-targeted drugs had significantly higher improvement rates in PASI scores compared to placebo, with an acceptable level of safety.

CONTRAST MEDIA & MOLECULAR IMAGING (2022)

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Article Dermatology

Multivariable Predictive Models to Identify the Optimal Biologic Therapy for Treatment of Patients With Psoriasis at the Individual Level

Mia-Louise Nielsen et al.

Summary: This study used statistical and machine learning models to identify the optimal biologic therapy for patients with psoriasis. The gradient-boosted decision trees performed better than logistic regression in predicting specific biologic therapy.

JAMA DERMATOLOGY (2022)

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Article Biotechnology & Applied Microbiology

HLA-Cw6 and other HLA-C alleles, as well as MICB-DT, DDX58, and TYK2 genetic variants associate with optimal response to anti-IL-17A treatment in patients with psoriasis

Martina Morelli et al.

Summary: This pharmacogenomic study examined the impact of genetic variants of psoriasis-risk loci on the clinical response to secukinumab, identifying specific SNPs associated with excellent response and defining patterns of SNPs related to different responses in HLA-Cw6(+) and HLA-Cw6(-) patients. Assessment of HLA-Cw6 and other allelic variants may help to identify patients who benefit most from anti-IL-17 therapy.

EXPERT OPINION ON BIOLOGICAL THERAPY (2021)

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Review Medicine, General & Internal

Inflammatory bowel disease and psoriasis: modernizing the multidisciplinary approach

C. R. H. Hedin et al.

Summary: Psoriasis and inflammatory bowel disease (IBD) are immune-mediated diseases with higher prevalence in northern Europe. Changes in gut microbiota play a key role in IBD pathogenesis, while genetic susceptibility has a greater impact on psoriasis.

JOURNAL OF INTERNAL MEDICINE (2021)

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Article Dermatology

Long-term Outcomes and Prognosis in New-Onset Psoriasis

Axel Svedbom et al.

Summary: This study found that clinical characteristics and activating genes in the IL-23 pathway are significantly associated with the clinical course of psoriasis, and joint pain and peripheral enthesitis may indicate the probability of PsA. Patients within those categories merit specialist referral and closer follow-up. The possibility of modifying the disease course with early systemic intervention should be tested.

JAMA DERMATOLOGY (2021)

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Review Health Care Sciences & Services

Influence of Genetic Polymorphisms on Response to Biologics in Moderate-to-Severe Psoriasis

Cristina Membrive Jimenez et al.

Summary: Biopharmaceutical treatments for moderate-to-severe psoriasis can vary in effectiveness and toxicity among individual patients, suggesting the potential for personalized treatment approaches in the future.

JOURNAL OF PERSONALIZED MEDICINE (2021)

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Review Clinical Neurology

Treatment approaches to patients with multiple sclerosis and coexisting autoimmune disorders

Tobias Brummer et al.

Summary: Advances in treatment of autoimmune diseases have led to more targeted and potent immunotherapies, posing challenges for physicians treating patients with multiple conditions. Some treatments are approved for multiple autoimmune disorders and offer new curative possibilities in related fields. Specific focus on common concomitant autoimmune conditions in patients with MS highlights potential overlaps and therapeutic combinations for more effective treatment.

THERAPEUTIC ADVANCES IN NEUROLOGICAL DISORDERS (2021)

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Review Gastroenterology & Hepatology

Global Prevalence and Bidirectional Association Between Psoriasis and Inflammatory Bowel Disease-A Systematic Review and Meta-analysis

Farzad Alinaghi et al.

JOURNAL OF CROHNS & COLITIS (2020)

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Review Biochemistry & Molecular Biology

Efficacy and Safety of Biologics for Psoriasis and Psoriatic Arthritis and Their Impact on Comorbidities: A Literature Review

Masahiro Kamata et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Review Dermatology

The role of the interleukin-23/Th17 pathway in cardiometabolic comorbidity associated with psoriasis

A. Egeberg et al.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2020)

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Review Dermatology

Phenotypic switch to eczema in patients receiving biologics for plaque psoriasis: a systematic review

A. Al-Janabi et al.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2020)

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Review Medicine, Research & Experimental

Psoriasis and Cardiovascular Risk: A Comprehensive Review

Walter Masson et al.

ADVANCES IN THERAPY (2020)

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Review Immunology

TNF-alpha inhibitors biosimilars as first line systemic treatment for moderate-to-severe chronic plaque psoriasis

Paolo Gisondi et al.

EXPERT REVIEW OF CLINICAL IMMUNOLOGY (2020)

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Review Pharmacology & Pharmacy

Pathogenesis of Chronic Plaque Psoriasis and Its Intersection With Cardio-Metabolic Comorbidities

Paolo Gisondi et al.

FRONTIERS IN PHARMACOLOGY (2020)

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Review Pharmacology & Pharmacy

A dermatologist perspective in the pharmacological treatment of patients with psoriasis and psoriatic arthritis

Francesco Bellinato et al.

EXPERT REVIEW OF CLINICAL PHARMACOLOGY (2020)

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Review Dermatology

Psoriasis: Which therapy for which patient Psoriasis comorbidities and preferred systemic agents

Shivani B. Kaushik et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2019)

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Article Dermatology

Defining the Therapeutic Range for Adalimumab and Predicting Response in Psoriasis: A Multicenter Prospective Observational Cohort Study

Nina Wilkinson et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2019)

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Review Pharmacology & Pharmacy

The pharmacological management of patients with comorbid psoriasis and obesity

Andrea Chiricozzi et al.

EXPERT OPINION ON PHARMACOTHERAPY (2019)

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Article Dermatology

Joint AAD-NPF guidelines of care for the management and treatment of psoriasis with awareness and attention to comorbidities

Craig A. Elmets et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2019)

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Article Rheumatology

Disease interception with interleukin-17 inhibition in high-risk psoriasis patients with subclinical joint inflammation-data from the prospective IVEPSA study

Eleni Kampylafka et al.

ARTHRITIS RESEARCH & THERAPY (2019)

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Article Dermatology

Consensus on the management of patients with psoriatic arthritis in a dermatology setting

P. Gisondi et al.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2018)

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Article Dermatology

Secukinumab treatment in new-onset psoriasis: aiming to understand the potential for disease modification - rationale and design of the randomized, multicenter STEPIn study

L. Iversen et al.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2018)

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Article Dermatology

Position statement for the management of comorbidities in psoriasis

E. Dauden et al.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2018)

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Article Dermatology

Italian guidelines on the systemic treatments of moderate-to-severe plaque psoriasis

P. Gisondi et al.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2017)

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Review Rheumatology

Tailored treatment options for patients with psoriatic arthritis and psoriasis: review of established and new biologic and small molecule therapies

Sarah Elyoussfi et al.

RHEUMATOLOGY INTERNATIONAL (2016)

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Article Dermatology

Treatment of coexistent psoriasis and lupus erythematosus

Sowmya Varada et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2015)

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Article Dermatology

European S3-Guidelines on the systemic treatment of psoriasis vulgaris - Update 2015-Short version - EDF in cooperation with EADV and IPC

A. Nast et al.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2015)

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Article Dermatology

Predicting treatment response in psoriasis using serum levels of adalimumab and etanercept: a single-centre, cohort study

S. K. Mahil et al.

BRITISH JOURNAL OF DERMATOLOGY (2013)

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Article Dermatology

Prevalence of cardiovascular risk factors in patients with psoriasis

Andrea L. Neimann et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2006)

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Tailored biological treatment for patients with moderate-to-severe psoriasis

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